Blood pressure and heart rate variabilities in normotensive and hypertensive human beings.

Mancia, Giuseppe; Ferrari, Alberto; Gregorini, L; Parati, Gianfranco; Pomidossi, G.; Bertinieri, G.; Grassı, Guıdo; Rienzo, Marco Di; Pedotti, A.; Zanchetti, Alberto

doi:10.1161/01.res.53.1.96

Cited by 684 publications

(424 citation statements)

References 28 publications

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“…Heart rate during activity may be an important prognostic factor of arterial alteration, however, nocturnal relations between heart rate and pulse wave velocity are similar to diurnal and 24-h measurements in our study. Mancia et al 17 have shown that blood pressure and heart rate vary directionally in a similar manner during daily activities. Previous studies have shown that 24-h variabilities of heart rate and blood pressure are mainly determined by sympathetic and parasympathetic activity.…”

Section: Discussionmentioning

confidence: 99%

Association between 24-hour ambulatory heart rate and arterial stiffness

Albaladéjo

Asmar

et al. 2000

J Hum Hypertens

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Clinical and experimental studies point to a positive association between carotid-femoral pulse wave velocity (PWVcf) and casual heart rate. However, an association with 24-h ambulatory heart rate has never been investigated. Twenty-four hour ambulatory heart rate and PWVcf (automatic computerised technique) were simultaneously measured in 213 subjects with untreated mild-to-moderate essential hypertension. It was found that mean ambulatory heart rate was higher in women than in men but the difference reached statistical significance only in those below 50 years of age during night-time measurements. As well as age and blood

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Section: Discussionmentioning

confidence: 99%

Association between 24-hour ambulatory heart rate and arterial stiffness

Albaladéjo

Asmar

et al. 2000

J Hum Hypertens

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“…of BP was significantly and positively correlated with the ambulatory BP, but the CV of SBP was independent of SBP. 14 Mancia et al 15 also reported that s.d., but not CV, of BP was greater in hypertensive subjects than in age-matched normotensive subjects. From these results, we thought that the CV of BP was less strongly correlated with BP than s.d.…”

Section: Coefficient Variation Of Home Blood Pressure E Ushigome Et Almentioning

confidence: 95%

The coefficient variation of home blood pressure is a novel factor associated with macroalbuminuria in type 2 diabetes mellitus

et al. 2011

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The purpose of this study was to investigate the association between day-by-day variability in home blood pressure (HBP) on 14 consecutive days and macroalbuminuria in patients with type 2 diabetes. We compared the coefficient of variation (CV) of HBP in 858 Japanese patients with and without macroalbuminuria. Next, we analyzed the relationship between the logarithm of urinary albumin excretion (UAE) and the CV of HBP using linear regression analysis. Then, we evaluated the association between the CV of HBP and macroalbuminuria, defined as UAE X300 mg g À1 creatinine, using logistic regression analysis. The CVs of morning and evening systolic blood pressure (SBP) were significantly greater in patients with macroalbuminuria than in those without (8.08±3.35 vs. 7.19±2.25%, Po0.05 and 9.01±3.58 vs. 7.98±2.57%, Po0.05, respectively). Multivariate linear regression analyses indicated that the CVs of morning SBP (Po0.05) and diastolic blood pressure (DBP; Po0.05), and those of evening SBP (Po0.05) were the independent explanatory variables for the logarithm of UAE. Multivariate logistic regression analyses also demonstrated that the odds ratio for the CVs of morning SBP, morning DBP and evening SBP for macroalbuminuria were 1.35 (Po0.05), 1.29 (Po0.05) and 1.44 (Po0.05), respectively. We conclude that the CV of HBP is correlated with macroalbuminuria, independent of the known risk factors, in Japanese patients with type 2 diabetes.

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“…1,2 Clinical evidence shows that both short-and long-term blood pressure variations occurring during a 24-h period increase progressively as subjects advance from normotensive to hypertensive. 3 Evidence also indicates that the prevalence and severity of end-organ damage from hypertension is closely related to the 24-h blood pressure average and blood pressure variability. [4][5][6] Finally, further studies unequivocally show that the magnitude of blood pressure variability has major prognostic relevance and predicts both nonfatal and fatal cardiovascular events.…”

Section: Introductionmentioning

confidence: 99%

Diurnal blood pressure variation and sympathetic activity

et al. 2010

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Blood pressure changes occurring over a 24-h period are under behavioral, humoral and reflex regulation. The sympathetic nervous system modulates blood pressure variation by affecting cardiac output and peripheral vascular resistance. This paper reviews evidence for the relationship between adrenergic neural drive and blood pressure as measured by direct and indirect approaches. This paper also reviews the sympathetic activity associated with increased 'in-office' and 'out-of-office' blood pressure, that is, the white-coat and the masked-hypertensive states. Finally, this paper examines altered neuroadrenergic influences on nocturnal blood pressure reduction and blood pressure variability.

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Blood pressure and heart rate variabilities in normotensive and hypertensive human beings.

Cited by 684 publications

References 28 publications

Association between 24-hour ambulatory heart rate and arterial stiffness

Association between 24-hour ambulatory heart rate and arterial stiffness

The coefficient variation of home blood pressure is a novel factor associated with macroalbuminuria in type 2 diabetes mellitus

Diurnal blood pressure variation and sympathetic activity

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