Blood pressure and hypertension during pregnancy in women with polycystic ovary syndrome: Odense Child Cohort

Nielsen, Julie H.; Birukov, Anna; Jensen, Richard Christian; Kyhl, Henriette Boye; Jørgensen, Jan Stener; Andersen, Marianne; Glintborg, Dorte

doi:10.1111/aogs.13914

Cited by 6 publications

(3 citation statements)

References 45 publications

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“…However, in the multivariate analyses adjusted for confounders, PCOS was no longer associated with hypertension; the subgroup analysis clearly showed that the risk was significantly higher only in non-obese women. Another study, somewhat in line with the previous results, reported that the presence of PCOS in pregnant women did not affect systolic and diastolic blood pressure values or the prevalence of hypertension [19]. However, a study by Lønnebotn et al reported that PCOS was related to hypertensive disorders in pregnancy (RR 1.62) in women with a specific body weight [20].…”

Section: Pcos and Hypertensionsupporting

confidence: 72%

Possible Effect of Polycystic Ovary Syndrome (PCOS) on Cardiovascular Disease (CVD): An Update

Profili,

Castelli,

Gidaro

et al. 2024

JCM

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Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during the fertile period. Women with PCOS have an increased risk of developing major cardiovascular risk factors during the fertile period: obesity, impaired glucose tolerance, diabetes mellitus, dyslipidemia, and metabolic syndrome. The possible effect of PCOS on cardiovascular disease (CVD) has been reported in different studies, but the results are not clear for several reasons. Indeed, most of the studies analyzed a cohort of fertile women who, given their relatively young age, have a low frequency of cardiovascular diseases. In addition, longitudinal studies have a short follow-up period, insufficient to draw firm conclusions on this topic. Finally, pharmacological treatment is limited by the lack of specific drugs available to specifically treat PCOS. In this review, we report on studies that analyzed the possible effect of PCOS on the most common CVD (hypertension, arterial stiffness, atherosclerosis, and cardiovascular event) and available drugs used to reduce CVD in PCOS women.

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Section: Pcos and Hypertensionsupporting

confidence: 72%

Possible Effect of Polycystic Ovary Syndrome (PCOS) on Cardiovascular Disease (CVD): An Update

Profili,

Castelli,

Gidaro

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…At the same time, a study by Kashyap S and Claman P shows a 31.8% risk of PIH in PCOS cases (20) . A study by Nielsen J H et al showed similar results for PIH in pregnant PCO and non-PCO women (8.5%, 8.9%), respectively (19) . In a study done by Radon P A et al, 22.7% of PCOS pregnant women developed PET (13) , which may relate to the small sample size in their study.…”

Section: Discussionmentioning

confidence: 76%

Pregnancy Complications and Outcomes in Women With Polycystic Ovarian Syndrome

Rahim

2022

JSMC

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Background Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder that has profound implications for women throughout their reproductive years. PCOS is associated with reproductive challenges, including difficulty in conceiving and pregnancy-related complications of miscarriage, hypertensive disorders, gestational diabetes and prematurity, and increased cesarean section(C/S) rate. Objectives To determine the pregnancy-related complications and outcomes in women with PCOS and to find the risk of these complications in obese and overweight. Patients and Methods Prospective cohort study was conducted in a Maternity teaching hospital and private hospitals and clinics in Sulaymaniyah City Jan. 2018 to Dec. 2021. Involved 313 women with PCOS trying to conceive. PCOS women were diagnosed by having two of the following three criteria, known as Rotterdam criteria (oligo-ovulation or anovulation, clinical or biochemical hyperandrogenism, and polycystic ovaries as seen by ultrasound scan), with the exclusion of other causes of androgen excess and menstrual cycle irregularity or amenorrhoea. They are followed a few months before conception, pregnancy and delivery. Way of conceiving (natural or by induction of ovulation), adverse pregnancy outcomes, and complications like early pregnancy loss, Pregnancy-induced hypertension (PIH), pre-eclampsia (PET), Gestational diabetes mellitus (GDM), preterm delivery, and mode of delivery were recorded. The risk of these complications in obese and overweight compared to normal weight cases was recorded. Results This study included 313 women with PCOS, pregnancy complications were PIH (12.1%), PET (2.2%), GDM (10.5%), pre-term delivery (4.5%), Miscarriage (19.5%), ectopic pregnancy (1.9%), biochemical pregnancy (1.6%), intrauterine fetal death(IUFD) 0.3%, the relation of these complications with pregnancy outcomes showed significant results with p-value of 0.04, 0.02, and 0.01 for PIH, PET, and GDM respectively. These complications were more in obese and overweight PCOS pregnant women than in normal-weight PCOS, but these associations were not significant. Conclusion Women with PCOS are at increased risk of adverse pregnancy outcomes; pre-pregnancy education, hormonal status regulation, diet and lifestyle changes, and weight loss with better follow-up of these women during pregnancy may decrease these complications. Introducing specific guidelines for pregnant women with PCOS may be beneficial.

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“…Pathophysiological studies have shown that insulin resistance plays a role in promoting the early stages of hypertension in pregnancy, such as vascular endothelial damage and hyperlipidemia, which may eventually lead to the development of hypertension in pregnancy [41,42]. Previous study [43] has found that preeclampsia is significantly related to homocysteinemia and insulin resistance. It is speculated that the pathological mechanism may directly damage endothelial cells through mechanisms such as hypomethylation, oxidative stress, and endothelial cell dysfunction, resulting in abnormal vasomotor function, which may be associated with the development of HDCP [44][45][46].…”

Section: Discussionmentioning

confidence: 98%

The risk factors of gestational hypertension in patients with polycystic ovary syndrome: a retrospective analysis

Zhou

Ji²,

Wang

2021

BMC Pregnancy Childbirth

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Background The hypertensive disorders complicating pregnancy (HDCP) is common in patients with polycystic ovary syndrome (PCOS), yet the potential influencing factors remained unclear. We aimed to assess the independent risk factors of HDCP in patients with PCOS, to provide clinical evidences for the management of PCOS. Methods Pregnant PCOS patients treated in our hospital from June 1, 2018 to November 30, 2020 were approached. The personal and clinical characteristics of patients with and without gestational hypertension were evaluated. Logistic regressions were conducted to identify the independent risk factors of HDCP, Receiver operating characteristics (ROC)curve analysis was conducted to evaluate the predicting value. Results A total of 188 PCOS patients were included, the incidence of HDCP in patients with PCOS was 27.66 %. There were significant differences in the age, BMI, family history of hypertension, the history of adverse pregnancy, history of contraceptive pills use and family history of HDCP between HDCP group and no-HDCP group (all p < 0.05), and there were no significant differences in the family history of diabetes, multiple pregnancy and long-term smoking history between HDCP group and no-HDCP group (all p > 0.05). Age ≥ 27y(OR2.048, 95 %CI1.121 ~ 3.208), BMI ≥ 24 kg/m2(OR1.463, 95 %CI1.069 ~ 2.011), family history of hypertension(OR2.129, 95 %CI1.093 ~ 3.042), the history of adverse pregnancy(OR2.435, 95 %CI1.264 ~ 4.085), history of contraceptive pills use(OR3.806, 95 %CI1.184 ~ 6.102), family history of HDCP(OR1.934, 95 %CI1.016 ~ 2.774) were the independent risk factors of HDCP in patients with PCOS (all p < 0.05). ROC curve analyses indicated that those factors had good predictive value on HDCP in PCOS patients. Conclusions The incidence of HDCP in PCOS patients is relatively high. In clinical practice, medical workers should carry out early prevention and intervention measures for these risk factors to reduce the incidence of HDCP.

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Blood pressure and hypertension during pregnancy in women with polycystic ovary syndrome: Odense Child Cohort

Cited by 6 publications

References 45 publications

Possible Effect of Polycystic Ovary Syndrome (PCOS) on Cardiovascular Disease (CVD): An Update

Possible Effect of Polycystic Ovary Syndrome (PCOS) on Cardiovascular Disease (CVD): An Update

Pregnancy Complications and Outcomes in Women With Polycystic Ovarian Syndrome

The risk factors of gestational hypertension in patients with polycystic ovary syndrome: a retrospective analysis

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