Blood pressure and left ventricular function changes in different ambulatory blood pressure patterns at high altitude

Abstract

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Early Left Ventricular Dysfunction and Non-Dipping: When Ejection Fraction is Not Enough. A Meta-Analysis of Speckle tracking Echocardiography Studies

“…The majority of studies investigating LV remodelling in patients with different circadian BP patterns reported a significant deterioration in LV structure and diastolic function in non-dippers in comparison with dippers (21,22,26,28,29). This may be related to the association between nocturnal hypertension in non-dippers and LV remodelling induced by overactivated sympathetic nervous system, renin-angiotensin-aldosterone system, sleep apnoea syndrome.…”

“…Mechanical LV changes recently implemented in clinical studies may reveal subclinical and subtle impairments in LV function previously undetectable with conventional echocardiographic assessment. Although differences were noticed for longitudinal, circumferential and radial strains (25,26,28), major attention has been paid to GLS, which represents not only a robust echocardiographic parameter that reveals subtle impairment of LV function, but also a paramount predictor of adverse outcomes, including mortality. GLS turned out to be a more sensitive and reproducible parameter than conventional LVEF in general (34) and hypertensive population (19).…”