Blood pressure and metabolic profile after surgical menopause: comparison with fertile and naturally-menopausal women

Abstract

In 1978 a random sample (367 men and 568 women aged 18-65 years) taken from the general population of a north-eastern Italian town was screened for cardiovascular risk; 16 years later, the women were invited to a second screening. Three groups were identified at the initial screening (fertile, naturally menopausal and surgically menopausal) and four in the longitudinal study (137 remained fertile during the whole study, 205 became naturally menopausal, 56 were ovariectomised and 127 were already going through the menopause). The protocol included a questionnaire, blood pressure (BP) measurement, and blood exams. Continuous variables were adjusted for confounders. Systolic BP, prevalence of hypertension, cholesterol, glycaemia and uricaemia were similar, whereas diastolic and triglycerides (TG) were lower in surgically-menopausal than in fertile women (P Ͻ 0.001). No significant difference in 16 years' variation from baseline was observed between

Gender differences in LDL- and HDL-cholesterol subfractions in patients after the acute ischemic stroke and their association with oxidative stress markers

“…Menopause induced surgically without hormone replacement therapy showed no effect on lipoprotein profile compared to hysterectomy with conservation of the ovaries. ( 15 , 16 ) Sexual dimorphism in metabolism of lipoproteins might be a consequence of a complex network of hormone actions combined with sex-specific modulators of lipid metabolism. One of the possible candidate could be insuline with its different action between males and females.…”

Orthostatic Hypotension Does Not Increase Cardiovascular Risk in the Elderly at a Population Level

“…In that case, acting at a population level, we demonstrated that, contrary to general belief, menopausal status is not a predictor of cardiovascular events once the models are adjusted for confounders. [55][56][57][58] Similar to menopause, OH seems not to be a risk factor in multivariate analysis of data from the general population. This evidence has important consequence in clinical practice.…”

Oophorectomy as a risk factor for coronary heart disease

“…Two studies compared CHD rates in women who underwent BSO at different ages, but did not evaluate women with BSO compared to ovarian conservation 30, 31. Four observational studies were excluded because they did not use multivariate models or other methods to account for the potential effects of confounding in the analysis 32–35…”