Blood Pressure and Pressor Response to Angiotensin II during Pregnancy and Nursing in the Rabbit

Katz, Michael; Creasy, Robert K.

doi:10.1159/000299605

Cited by 9 publications

(11 citation statements)

References 9 publications

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“…Though these groups carried out their experiments on unanaesthetized rabbits whereas those of our study and that of O 'Brien et al (1977) were anaesthetized, this is only one of the factors which may contribute to the divergent findings. Thus Katz and Creasy (1981) found infusion of angiotensin I1 at 50 ng/kg per min raised arterial pressure in their pregnant rabbits by 14 mmHg; this is virtually identical to the rise of 14.9 mmHg found in this study when angiotensin I1 was infused at 54 pmol/kg per min, which is equivalent to 55 ng/kg per min ( Table 3). It is the results from the two laboratories for the non-pregnant animals that appear to conflict.…”

Section: Discussionsupporting

confidence: 80%

“…O'Brien et al (1977) injected angiotensin in a range of doses similar to those used in the present study and found the percentage increase in mean arterial pressure to be greater in pregnant rabbits. On the other hand, Berssenbrugge et al (1980), Katz and Creasy (1981) and Lee et al (1982) found a diminished response to angiotensin I1 in pregnant rabbits. Though these groups carried out their experiments on unanaesthetized rabbits whereas those of our study and that of O 'Brien et al (1977) were anaesthetized, this is only one of the factors which may contribute to the divergent findings.…”

Section: Discussionmentioning

confidence: 95%

“…It is the results from the two laboratories for the non-pregnant animals that appear to conflict. However, whereas we did our best to match our pregnant rabbits with virgin non-pregnant ones from the same supplier and at the same age, Katz and Creasy (1981) followed individual pregnant rabbits postpartum and took the responses of these animals during the puerperium as their control values. This raises doubts as to whether the puerperal rabbit and the virgin female may themselves differ in sensitivity to angiotensin 11.…”

Section: N Joels and P W Humphreysmentioning

confidence: 99%

“…1977) and diminished (Berssenbrugge et af. 1980;Katz & Creasy 1981; Lee el a/. 1982) in the pregnant rabbit.…”

Section: Introductionmentioning

confidence: 98%

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Effect of Pregnancy in the Rabbit on the Pressor Response to Angiotensin and Noradrenaline

Joels

Humphreys

1985

Clin Exp Pharma Physio

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The pressor responses to angiotensin II injections of 29, 117 and 468 pmol/kg and infusion at 54 pmol/kg per min were compared in near-term pregnant and matched non-pregnant rabbits. The responses to noradrenaline injections of 652, 2608 and 10 432 pmol/kg and infusion at 1185 pmol/kg per min were similarly compared. At all doses of angiotensin and noradrenaline, whether by injection or infusion, the response of the pregnant animals was significantly greater. However the control arterial pressures of the pregnant rabbits were lower and fell in a range where the baroreceptor reflex might be less effective. Thus less efficient buffering could contribute to the greater response to the vasoconstrictor agents. To test the effect of pregnancy on the vascular response to angiotensin and noradrenaline when reflex and central effects were excluded, hexamethonium was used to produce autonomic ganglion blockade. The response to both vasoconstrictors was now less in the pregnant rabbits than in the non-pregnant. Thus in assessing the effects of pregnancy on the responses of the rabbit to angiotensin and noradrenaline the effect of pregnancy on mean blood pressure must be taken into account, since this can influence the extent to which the arterial baroreceptors may modulate the response.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 95%

Section: N Joels and P W Humphreysmentioning

confidence: 99%

“…1977) and diminished (Berssenbrugge et af. 1980;Katz & Creasy 1981; Lee el a/. 1982) in the pregnant rabbit.…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Effect of Pregnancy in the Rabbit on the Pressor Response to Angiotensin and Noradrenaline

Joels

Humphreys

1985

Clin Exp Pharma Physio

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“…In studies on the effect of exogenous A11 in rabbits (Katz & Creasy 1981) it was shown that the blood pressure response was reduced much to the same extent during lactation and during late pregnancy. Our lactating goats, however, showed a pressor response to A11 similar to, or greater than that during anoestrus.…”

Section: Discussionmentioning

confidence: 97%

Blood pressure response to angiotensin II in pregnant and lactating goats maintained on high or low sodium intake

Olsson

Dahlborn

Karlberg³

1987

Acta Physiologica Scandinavica

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Goats were kept on either high (274 mmol day-1) or low (68 mmol day-1) sodium intake during pregnancy, lactation, and anoestrus. High salt (HS) animals had about three times greater renal Na excretion than low salt (LS) animals, but the differences in plasma volume, protein concentration, and haematocrit were generally not significant. Angiotensin II (AII) was infused intravenously for 28-min periods in doses of 0.30, 0.75, or 1.00 nmol min-1. The increase in mean arterial blood pressure (MAP) during AII infusions was greater in HS than in LS goats, but became attenuated in all animals during the course of the pregnancy. In LS goats the MAP rise was smaller in late pregnancy than during lactation and anoestrus. In HS goats the rise in MAP was exaggerated in early pregnancy and was similar to lactation and anoestrus values in late pregnancy. During lactation and anoestrus the goats showed similar MAP increase in response to AII infusions. The pulse pressure was greater during AII infusions performed in early pregnancy, lactation and anoestrus than in late pregnancy. Cardiac arrhythmias were noted during AII infusions, most frequently during lactation and in HS goats in early pregnancy. The results show that a moderately elevated sodium intake causes a significantly higher MAP increase in response to AII infusions during pregnancy. This abolishes the reduction of the MAP increase to AII infusions during late pregnancy as compared to anoestrus; a phenomenon which is observed in goats on a low sodium intake.

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Responses to systemic angiotensin II in lactating and non-lactating goats

Hossaini-Hilali

Olsson

1996

Regulatory Peptides

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Blood Pressure and Pressor Response to Angiotensin II during Pregnancy and Nursing in the Rabbit

Cited by 9 publications

References 9 publications

Effect of Pregnancy in the Rabbit on the Pressor Response to Angiotensin and Noradrenaline

Effect of Pregnancy in the Rabbit on the Pressor Response to Angiotensin and Noradrenaline

Blood pressure response to angiotensin II in pregnant and lactating goats maintained on high or low sodium intake

Responses to systemic angiotensin II in lactating and non-lactating goats

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