Blood pressure and the brain: the neurology of hypertension

Kelly, Dearbhla M.; Rothwell, Peter M.

doi:10.1136/practneurol-2019-002269

Cited by 46 publications

(36 citation statements)

References 85 publications

(79 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The importance of AH as a risk factor for many pathologies, including neurological disorders [ 50 ] and regrettably widespread hypertensive retinopathy, warrants exploring how retinal function is affected in L-NAME-induced arterial hypertension. In that experimental group, our ERG recordings exhibited a remarkable reduction in amplitudes of b-scot (rod functionality), b-mix and a-mix waves, and a sightly reduction in OP, but no differences were attributable to AH in b-phot (cone activity) and FL waves.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Action of Dietary Wild Olive (Acebuche) Oil in the Retina of Hypertensive Mice

Santana-Garrido

Reyes-Goya

Milla-Navarro

et al. 2021

Foods

View full text Add to dashboard Cite

Inflammation plays a crucial role in the course of eye diseases, including many vascular retinopathies. Although olive oil is known to have beneficial effects against inflammatory processes, there is no information available on the anti-inflammatory potential of the wild olive tree (namely, acebuche (ACE) for the primitive Spanish lineages). Here we investigate the anti-inflammatory effects of ACE oil in the retina of a mouse model of arterial hypertension, which was experimentally induced by administration of L-NAME (NG-nitro-L-arginine-methyl-ester). The animals were fed supplements of ACE oil or extra virgin olive oil (EVOO, for comparative purposes). Retinal function was assessed by electroretinography (ERG), and different inflammation-related parameters were measured in the retina and choroid. Besides significant prevention of retinal dysfunction shown in ERG recordings, ACE oil-enriched diet upregulated the expression of the anti-inflammatory markers PPARγ, PPARα and IL-10, while reducing that of major proinflammatory biomarkers, IL-1β, IL-6, TNF-α and COX-2. This is the first report to highlight the anti-inflammatory properties of an ACE oil-enriched diet against hypertension-related retinal damage. Noteworthy, dietary supplementation with ACE oil yielded better results compared to a reference EVOO.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Action of Dietary Wild Olive (Acebuche) Oil in the Retina of Hypertensive Mice

Santana-Garrido

Reyes-Goya

Milla-Navarro

et al. 2021

Foods

View full text Add to dashboard Cite

show abstract

“…Participant to set blood pressure goal for the following month. 4. Participant to set goals for diet, exercise, and medication adherence for the following month.…”

Section: Pharmacist Health Coachingmentioning

confidence: 99%

“…Hypertension is one of the most important preventable risk factors contributing to premature cardiovascular morbidity and mortality in Australia [1][2][3]. Essential hypertension is defined as having persistent systolic and diastolic blood pressure (BP) of 140 and 90 mmHg or higher, respectively [4]. Although not curable, hypertension, under the guidance of a qualified health care professional, is a manageable lifelong condition.…”

Section: Introductionmentioning

confidence: 99%

A pharmacist health coaching trial evaluating behavioural changes in participants with poorly controlled hypertension

2021

View full text Add to dashboard Cite

Background To investigate whether pharmacist health coaching improves progression through the stages of change (SOC) for three modifiable health behaviours; diet, exercise, and medication management in participants with poorly controlled hypertension. Methods In this four-month controlled group study two community-based pharmacists provided three health coaching sessions to 20 participants with poorly controlled hypertension at monthly intervals. Changes in participants’ stages of change with respect to the modifiable health behaviours; diet, exercise, and medication management were assessed. To confirm the behaviour change outcomes, SOC were also assessed in a control group over the same period. Results Statistically significant changes in the modifiable health behaviours- medication management (d = 0.19; p = 0.03) and exercise (d = 0.85; p = 0.01) were apparent in participants who received health coaching and were evident through positive changes in the SOC charts. The participants in the control group did not experience significant changes with respect to the SOC. This was parallel to a decrease in mean systolic blood pressure from session one to session four by 7.53 mmHg (p < 0.05, d = − 0.42) in participants who received health coaching. Improvements to medication adherence was also apparent in these participants, evident from the mean scores for the Adherence to Refills and Medications Scale (ARMS), which decreased significantly from a mean of 15.60 to 13.05 (p < 0.05) from session one to four. Conclusions Pharmacist health coaching produced promising health outcomes in participants with poorly controlled hypertension. Pharmacists were able to facilitate a positive behaviour change in participants. However, larger participant cohorts are needed to explore these findings further. Trial registration Australia New Zealand Clinical Trials Registry ACTRN12618001839291. Date of registration 12/11/2018.

show abstract

“…Therefore, recent studies have identified the role of blood pressure variability as an independent risk factor for the progression of organ damage related to hypertension, including brain damage and cognitive impairment [ 6 ]. However, it is not known whether increased blood pressure variability is the cause or result of organ damage and should be considered as one of the new targets of hypertension treatment [ 4 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Pathogenetic Mechanisms of Hypertension–Brain-Induced Complications: Focus on Molecular Mediators

Chiara

Cuore

Daidone

et al. 2022

IJMS

View full text Add to dashboard Cite

There is growing evidence that hypertension is the most important vascular risk factor for the development and progression of cardiovascular and cerebrovascular diseases. The brain is an early target of hypertension-induced organ damage and may manifest as stroke, subclinical cerebrovascular abnormalities and cognitive decline. The pathophysiological mechanisms of these harmful effects remain to be completely clarified. Hypertension is well known to alter the structure and function of cerebral blood vessels not only through its haemodynamics effects but also for its relationships with endothelial dysfunction, oxidative stress and inflammation. In the last several years, new possible mechanisms have been suggested to recognize the molecular basis of these pathological events. Accordingly, this review summarizes the factors involved in hypertension-induced brain complications, such as haemodynamic factors, endothelial dysfunction and oxidative stress, inflammation and intervention of innate immune system, with particular regard to the role of Toll-like receptors that have to be considered dominant components of the innate immune system. The complete definition of their prognostic role in the development and progression of hypertensive brain damage will be of great help in the identification of new markers of vascular damage and the implementation of innovative targeted therapeutic strategies.

show abstract

Blood pressure and the brain: the neurology of hypertension

Cited by 46 publications

References 85 publications

Anti-Inflammatory Action of Dietary Wild Olive (Acebuche) Oil in the Retina of Hypertensive Mice

Anti-Inflammatory Action of Dietary Wild Olive (Acebuche) Oil in the Retina of Hypertensive Mice

A pharmacist health coaching trial evaluating behavioural changes in participants with poorly controlled hypertension

Pathogenetic Mechanisms of Hypertension–Brain-Induced Complications: Focus on Molecular Mediators

Contact Info

Product

Resources

About