Blood pressure and the perception of illusive pain

Scheuren, Raymonde; Duschek, Stefan; Schulz, André; Sütterlin, Stefan; Anton, Fernand

doi:10.1111/psyp.12658

Cited by 11 publications

(6 citation statements)

References 99 publications

(161 reference statements)

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“…The stimulation of TRPA1 by AITC in high concentrations may be also associated with the participation of the TRPA1 in the formation of the pain signal. There is no unambiguous data on the change in blood pressure at pain -a number of studies have noted a drop in pressure and increase in heart rate during pain [21], in others, there is an increase in blood pressure during pain [22]. The results of our studies with a high concentration of AITC when the significant increase in heart rate and decrease in blood pressure was observed are close to the data of Scheuren and co-authors [21].…”

Section: Conflicts Of Interestsupporting

confidence: 86%

“…There is no unambiguous data on the change in blood pressure at pain -a number of studies have noted a drop in pressure and increase in heart rate during pain [21], in others, there is an increase in blood pressure during pain [22]. The results of our studies with a high concentration of AITC when the significant increase in heart rate and decrease in blood pressure was observed are close to the data of Scheuren and co-authors [21]. The cutaneous nociceptors can be one of the reasons for the decrease of the arterial pressure at the high activation of the TRPA1 ion channel in the skin.…”

Section: Conflicts Of Interestmentioning

confidence: 99%

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Effect of Various Activation of the Skin TRPA1 Ion Channel on Cardiovascular Systemic Parameters in Hypertensive Rats

Tv¹,

Es²

2021

Int Arch Clin Pharmacol

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The effect of different activation of the skin TRPA1 ion channel on the parameters of the cardiovascular system was studied in rats with hereditary stress-induced hypertension while recovery from anesthesia. The activation of the TRPA1 ion channel was performed by application to skin its agonist -allyl isothiocyanate (AITC) in two concentrations 2.5% and 0.5%. The following parameters were measured that characterize the work of the cardiovascular system: Blood pressure (systolic, diastolic, and mean), heart rate, blood flow, and tail blood volume. Stimulation of the TRPA1 ion channel by 2.5% AITC resulted in a diminishing rate of increase in blood pressure and a sharp increase in heart rate while recovering from anesthesia. The mean rate of the arterial pressure rise during recovery from anesthesia was 0.4 ± 0.16 mmHg/min compared to 1.4 ± 0.19 mmHg/ min in control (solvent application), P < 0.01. The heart rate increase was 4.7 ± 0.28 beats/min2 compared to 0.6 ± 0.39 beats/min2 in control (P < 0.001). Parameters of blood flow and the tail blood volume were not significantly changed at 2.5% AITC compared to control. The effect of 0.5% AITC on cardiovascular parameters was another. There was no influence on the recovery of arterial pressure and the heart rate, but there was a pronounced acceleration in the recovery of blood flow and tail blood volume after anesthesia. The mean rate for blood flow recovery at 0.5% AITC application was 0.3 ± 0.07 ml/min2 against 0.1 ± 0.05 ml/min2 in control (P < 0.03) and for the tail blood volume was 1.2 ± 0.33 μl/ min against 0.4 ± 0.14 μl/min in control (P < 0.02). Thus, the influence of the skin TRPA1 ion channel on the parameters of the cardiovascular system depends on the degree of its activation. A low level of the TRPA1 stimulation enhanced the blood flow, while a higher level of the TRPA1 activation discouraged to increase in arterial pressure and significantly increased the heart rate. The results suggest the possibility of the therapeutic use of TRPA1 ion channel activation.

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Section: Conflicts Of Interestsupporting

confidence: 86%

Section: Conflicts Of Interestmentioning

confidence: 99%

Effect of Various Activation of the Skin TRPA1 Ion Channel on Cardiovascular Systemic Parameters in Hypertensive Rats

Tv¹,

Es²

2021

Int Arch Clin Pharmacol

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“…There is clear evidence showing that blood pressure readings vary with pain intensity. Scheuren et al (2016) explained that the numerical rating scale can be used to quantify subjective pain intensity and pain unpleasantness. Subjects were classified as responders and non-responders to thermal grill stimulation based on pain intensity ratings.…”

Section: Physiological Signalsmentioning

confidence: 99%

Experimental Exploration of Objective Human Pain Assessment Using Multimodal Sensing Signals

et al. 2022

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Optimization of pain assessment and treatment is an active area of research in healthcare. The purpose of this research is to create an objective pain intensity estimation system based on multimodal sensing signals through experimental studies. Twenty eight healthy subjects were recruited at Northeastern University. Nine physiological modalities were utilized in this research, namely facial expressions (FE), electroencephalography (EEG), eye movement (EM), skin conductance (SC), and blood volume pulse (BVP), electromyography (EMG), respiration rate (RR), skin temperature (ST), blood pressure (BP). Statistical analysis and machine learning algorithms were deployed to analyze the physiological data. FE, EEG, SC, BVP, and BP proved to be able to detect different pain states from healthy subjects. Multi-modalities proved to be promising in detecting different levels of painful states. A decision-level multi-modal fusion also proved to be efficient and accurate in classifying painful states.

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“…A custom-built and water-bath driven thermal grill device was used to apply the thermal stimuli (Curio, I., PhD, Medical Electronics, Bonn/Germany; (28,38,39). The thermal grill (…”

Section: Thermal Grill Devicementioning

confidence: 99%

Somatic Symptom Perception From a Predictive Processing Perspective: An Empirical Test Using the Thermal Grill Illusion

et al. 2020

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Objective: In a predictive coding perspective, symptom perceptions result from an integration of pre-existing information in memory with sensory input. Physical symptoms can therefore reflect the relative predominance of either sensory input or pre-existing information. In this study, we used the thermal grill illusion (TGI), which applies interlaced warm and cool temperatures to the skin to create a paradoxical heat-pain experience. Assuming that the TGI compared to single temperature stimulation relies more importantly on an active integration process of the brain to create this paradoxical sensation, we tested the hypothesis whether a manipulation of the expectations during TGI would have more impact than during single temperature stimulation. Methods: Sixty-four participants received different temperature combinations (16/16 °C, 40/40 °C, 16/40 °C) with neutral, positive ("placebo"), and negative ("nocebo") instructions. Subjective stimulus intensity was rated and neuroticism and absorption (openness to absorbing and self-altering experiences) served as potential moderating traits. Results: The TGI condition was rated highest. Overall, negative instructions increased (p < .001, d = 0.58), whereas positive instructions did not significantly change the TGI intensity perception (vs. neutral; p = .144, d = 0.19). In the TGI condition, increased modulation of pain was observed with higher neuroticism (β = .33, p = .005) and absorption (β = 0.30, p = .010). Conclusions: Whereas negative instructions induced a nocebo effect, no placebo effect emerged after positive instructions. The findings are in line with the predictive coding model of symptom perception for participants with higher levels of neuroticism and absorption.

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Blood pressure and the perception of illusive pain

Cited by 11 publications

References 99 publications

Effect of Various Activation of the Skin TRPA1 Ion Channel on Cardiovascular Systemic Parameters in Hypertensive Rats

Effect of Various Activation of the Skin TRPA1 Ion Channel on Cardiovascular Systemic Parameters in Hypertensive Rats

Experimental Exploration of Objective Human Pain Assessment Using Multimodal Sensing Signals

Somatic Symptom Perception From a Predictive Processing Perspective: An Empirical Test Using the Thermal Grill Illusion

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