Blood Pressure, Arterial Stiffness, and Open-angle Glaucoma

Abstract

To investigate cross-sectional associations among blood pressures (BPs), arterial stiffness, and openangle glaucoma (OAG). M e t h o d s : Study participants came from the population-based Rotterdam Study. The baseline examination phase took place after an extensive home inter-

Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma

“…[15][16][17] Many studies support the role of vascular factors in glaucoma. Large epidemiologic studies have observed adverse associations with low ocular perfusion pressure 18 or low systemic blood pressure, 19 and open-angle glaucoma frequency or risk. 20,21 In addition, the Early Manifest Glaucoma Trial 22 identified predictors of POAG disease progression that included lower systolic blood and perfusion pressure.…”

Twenty-four-hour intraocular pressure and ocular perfusion pressure characteristics in newly diagnosed patients with normal tension glaucoma

“…Several studies have linked such hemodynamic alterations to the development and subsequent progression of glaucoma. [15][16][17][18][19][20][21][22]24,25 In our NTG cohort, IOP readings at night were higher in the supine than the sitting position. Elevated supine IOP can be attributed to the effect of increased episcleral pressure in the supine position.…”

“…Besides IOP, it is widely agreed that MOPP is implicated in glaucoma development and progression. 3,48 A significant body of literature has linked low ocular perfusion pressure to the incidence, 16 prevalence, [17][18][19][20][21][22] and progression of open-angle glaucoma. 15 For example, the population-based Egna-Neumarkt study found an increased risk of glaucomatous damage for Caucasian POAG (but not NTG) patients with DOPP lower than 70 mmHg.…”

“…[12][13][14] A parameter that has been strongly associated with glaucoma prevalence and progression is ocular perfusion pressure (OPP). [15][16][17][18][19][20][21][22] More specifically, evidence has highlighted the role of reduced OPP in the incidence, 16 prevalence, [17][18][19][20][21][22] and progression of glaucomatous neuropathy 15 in several ethnic groups. Particularly in NTG, increased OPP fluctuation has been linked to the severity of disease at diagnosis 23 and the subsequent risk of progression.…”

A Vascular Approach to Glaucoma

“…While there are studies showing a correlation between higher blood pressure and a higher prevalence of glaucoma (Tielsch, 1995) (Mitchell, 2004), this has not been the case in the Barbados Study, in which baseline hypertension actually decreased the risk for primary open-angle glaucoma (Leske, 2002). More consistently, a lower ocular perfusion pressure (perfusion pressure = blood pressure-IOP), in particular a lower diastolic OPP, has been associated with a significant increase in the risk for glaucoma (Leske, 2002) (Hulsman CA., 2007). Because measuring the local arterial pressure in the eye is not currently feasible, epidemiologic and other studies calculate ocular perfusion pressure from the brachial artery blood pressure and IOP.…”