Blood Pressure Change in Intrafascicular Vagal Activities

Guo, Jin Yun; Li, Runhuan; Wang, Jiaojiao; Arranz, Javier; Li, Yiran; Chai, Xiaodong; Wang, Ji‐Guang; Sui, Xiaohong

doi:10.1007/s12204-021-2259-7

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…The blood pressure recording device is the NL108A (hydraulic pressure sensor, Digitimer Company), its sensor is connected with Micro1401 (Cambridge Electronic Design Company), and the data are transmitted to the computer and analyzed with the software “spike9.” Rats with stable anesthesia were injected with phenylephrine every 10 min to achieve a periodical “sharp rise-slow fall” change of blood pressure. The data acquired from the recording function were analyzed with the software “MATLAB” on the computer ( 23 ).…”

Section: Methodsmentioning

confidence: 99%

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A system of real-time neural recording and stimulation and its potential application in blood pressure modulation

Shen

et al. 2022

Front. Med. Technol.

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Hypertension is one of the most prevalent chronic diseases that affects more than 20% of the adult population worldwide, but fortunately, most of their blood pressure can be effectively controlled via drug treatment. However, there still remains 5–30% of patients clinically who do not respond well to conventional medication, while the non-drug treatments currently existing are struggling with major drawbacks like irreversible nerve damage, huge side effects, and even non-effectiveness. In this study, based on the physiological regulation mechanism of blood pressure and state-of-the-art neuromodulation technique, we worked along with the vagus nerve stimulation scheme, developed, and explored whether and how a real-time neural recording and stimulation system could provide an insight into self-adaptive modulation in the blood pressure, in the hope to crack a crevice in the closed-loop treatment for resistant hypertension. Unlike traditional neuromodulation devices, additional signal recording and real-time wireless transmission functions are added to the same device to realize the features of a dynamic monitor and modulator. The system is tested both in vitro and in vivo, showing decent electrical performance of 8 kHz sampling rate and flexible stimulation outputs which sufficiently covers our needs in manipulating neural activities of interest. A relatively stable drop in the blood pressure resulting from stimulation was observed and specific patterns in the vagus nerve signals relating to blood pressure could also be primarily identified. This laid a solid foundation for further studies on the final realization of closed-loop automatic adjustment for resistive hypertension treatment.

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Section: Methodsmentioning

confidence: 99%

“…Rats with stable anesthesia were injected with phenylephrine every 10 min to achieve a periodical "sharp riseslow fall" change of blood pressure. The data acquired from the recording function were analyzed with the software "MATLAB" on the computer (23).…”

Section: Electrophysiological Experimentsmentioning

confidence: 99%