Blood pressure elevation in young dogs during low-level lead poisoning

Fine, Burton P.; Vetrano, Thomas; Skurnick, Joan; Ty, Antonia

doi:10.1016/0041-008x(88)90041-5

Cited by 16 publications

(8 citation statements)

References 22 publications

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“…Animal investigations support a pressor effect of lead at low dose (Fine et al 1988; Gonick et al 1997; Vaziri 2002). Epidemiologic investigations conducted in large general population samples (e.g., Harlan 1988; Nash et al 2003; Pocock et al 1988; Schwartz 1988) suggest lead may elevate blood pressure in adults at blood lead concentrations < 20 μg/dL.…”

Section: Health Effects At Low Dosementioning

confidence: 87%

Recommendations for Medical Management of Adult Lead Exposure

Kosnett

Wedeen

Rothenberg

et al. 2007

Environ Health Perspect

324

253

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Research conducted in recent years has increased public health concern about the toxicity of lead at low dose and has supported a reappraisal of the levels of lead exposure that may be safely tolerated in the workplace. In this article, which appears as part of a mini-monograph on adult lead exposure, we summarize a body of published literature that establishes the potential for hypertension, effects on renal function, cognitive dysfunction, and adverse female reproductive outcome in adults with whole-blood lead concentrations < 40 μg/dL. Based on this literature, and our collective experience in evaluating lead-exposed adults, we recommend that individuals be removed from occupational lead exposure if a single blood lead concentration exceeds 30 μg/dL or if two successive blood lead concentrations measured over a 4-week interval are ≥ 20 μg/dL. Removal of individuals from lead exposure should be considered to avoid long-term risk to health if exposure control measures over an extended period do not decrease blood lead concentrations to < 10 μg/dL or if selected medical conditions exist that would increase the risk of continued exposure. Recommended medical surveillance for all lead-exposed workers should include quarterly blood lead measurements for individuals with blood lead concentrations between 10 and 19 μg/dL, and semiannual blood lead measurements when sustained blood lead concentrations are < 10 μg/dL. It is advisable for pregnant women to avoid occupational or avocational lead exposure that would result in blood lead concentrations > 5 μg/dL. Chelation may have an adjunctive role in the medical management of highly exposed adults with symptomatic lead intoxication but is not recommended for asymptomatic individuals with low blood lead concentrations.

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Section: Health Effects At Low Dosementioning

confidence: 87%

Recommendations for Medical Management of Adult Lead Exposure

Kosnett

Wedeen

Rothenberg

et al. 2007

Environ Health Perspect

324

253

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show abstract

“…Most studies indicate a relationship between low level lead exposure and hypertension in humans and animals [Fine et al, 1988;Harlan, 1988;Kromhout, 1988;Perry et al, 1988;Victery, 1988] while one study does not [Selevan et al, 1988], Low level lead exposure affects the electrical and mechanical activity of the heart in animals [Kopp et al 1988], Atherosclerosis can be induced by lead ions [Revis et al, 1981]. Lead ions can induce lipid peroxidation [Quinlan et al, 1988;Ali and Bondy, 1989], Lead expo sure results in decreased antibody formation in mice [Roller and Kovacic, 1974], High concentrations of lead have been found in senile cataractous human lenses [Racz and Erdohelyi, 1988], Behavior impairment in both monkeys [Gilbert and Rice, 1987] and humans [Needleman et al, 1990] appears to be a persistent legacy of low level lead expo sure.…”

Section: Discussionmentioning

confidence: 99%

Lead Accumulation in the Bones of Aging Male Mice

Massie

Aiello²

1992

Gerontology

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The lead content of mouse femurs increased by 83% between 76 and 958 days of age with values ranging from 0.192 to 1.78 ng Pb/mg dry weight. These values are remarkably lower than in previous reports for the lead content of bone. The lead content of mouse liver showed no aging-related trend with values ranging from 0.00823 to 0.0149 ng/mg dry weight. Bone density, calcium and collagen content were not related to the lead content. We conclude that while bone lead content is very low in mice, it increases with aging but does not appear to be related to the osteopenia which develops in the C57BL/6J male mouse.

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“…The exposure of two dogs to very high levels of lead did not invoke an increase in blood pressure but did produce acute episodes of lead poisoning (20). In a paper by Fine et al (21), three young dogs received a low dose of lead (1 mg/kg daily, blood lead concentration of 36 Rg/dL) and were found to develop a persistent (from 10 days to 20 weeks) 12-mm Hg increase in mean arterial pressure when compared to their paired control dogs. Additional determinations of the renin profile show that renin is initially elevated (at 28 days exposure) but then returns to normal levels while blood pressure remains elevated.…”

Section: Introductionmentioning

confidence: 96%

Evidence for Effects of Chronic Lead Exposure on Blood Pressure in Experimental Animals: An Overview

Victery¹

1988

Environmental Health Perspectives

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Blood pressure elevation in young dogs during low-level lead poisoning

Cited by 16 publications

References 22 publications

Recommendations for Medical Management of Adult Lead Exposure

Recommendations for Medical Management of Adult Lead Exposure

Lead Accumulation in the Bones of Aging Male Mice

Evidence for Effects of Chronic Lead Exposure on Blood Pressure in Experimental Animals: An Overview

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