Blood Pressure, Left Ventricular Geometry, and Systolic Function in Children Exposed to Inorganic Arsenic

Osorio-Yáñez, Citlalli; Ayllon-Vergara, Julio C.; Arreola-Mendoza, Laura; Aguilar-Madrid, Guadalupe; Hernández-Castellanos, Erika; Sánchez-Peña, Luz C.; Razo, Luz M. Del

doi:10.1289/ehp.1307327

Cited by 34 publications

(18 citation statements)

References 43 publications

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“…Many prospective studies have confirmed a strong association between BP levels and risk of CVD [ 24 , 25 ]. A number of study reported that the prevalence of hypertension was positively related to As exposure [ 26 – 31 ]. In a prospective study, maternal urinary arsenic during pregnancy was correlated with BP in children at 4.5 years of age [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Arsenic exposure assists ccm3 genetic polymorphism in elevating blood pressure

et al. 2017

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Epidemiologic study has suggested that arsenic exposure is positively related to increased blood pressure. However, the underlying mechanism concerning interaction between genetic polymorphisms and arsenic exposure remains unclear. In present study, within 395 Chinese, the effects of interaction between arsenic exposure and CCM3 gene polymorphisms on elevation of blood pressure were probed by multiple Logistic regression models after adjusting for confounding factors. Firstly, we found that serum arsenic was positively associated with blood pressure, cholesterol, glucose and C-reactive protein. Then, adjusted for confounding factors of age, gender, smoking, alcohol consumption, BMI and degree of education, arsenic exposure incurred the hazard of increased systolic pressure and diastolic pressure, with odds ratios (ORs) being 1.725 and 1.425, respectively. Distinctly, we found that interactions between rs3804610* rs9818496, rs6784267*rs9818496, and rs3804610* rs6784267 variant genotype can increase significantly risks of SBP. Additionally, interactions between rs9818496, rs3804610 and rs6784267 genotypic variantions and arsenic exposure boosted the hazard of increased systolic pressure, with ORs being 1.496, 1.496 and 1.312. In conclusion, our fingdings suggest that As exposure of population can assist CCM3 polymorphism in elevating SBP.

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Section: Discussionmentioning

confidence: 99%

Arsenic exposure assists ccm3 genetic polymorphism in elevating blood pressure

et al. 2017

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“…19 In children, early life As exposure has been associated with early indicators of cardiovascular risk, including increased blood pressure, as well as carotid intima media thickness (cIMT). 20–22 …”

Section: Introductionmentioning

confidence: 99%

Maternal and infant inflammatory markers in relation to prenatal arsenic exposure in a U.S. pregnancy cohort

Farzan

Brickley

et al. 2017

Environmental Research

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Introduction Accumulating evidence indicates that arsenic (As), a potent environmental toxicant, may increase cardiovascular disease risk and adversely affect endothelial function at high levels of exposure. Pregnancy is a vulnerable time for both mother and child; however, studies examining the association between prenatal As exposure and plasma biomarkers of inflammation and endothelial function in mothers and newborns are lacking. Methods We examined maternal urinary As levels at gestational weeks 24 to 28 and levels of inflammatory biomarkers in plasma from 563 pregnant women and 500 infants’ cord blood. We assessed a multiplexed panel of circulating inflammatory and endothelial function markers, including tumor necrosis factor alpha (TNFα), monocyte chemoattractant protein 1 (MCP1), intercellular adhesion molecule (ICAM1) and vascular cell adhesion molecule (VCAM1). Results Compared with the bottom tertile, the highest tertile of maternal urinary As during pregnancy was associated with a 145.2 ng/mL (95% CI 4.1, 286.3; p=0.04) increase in cord blood ICAM1 and 557.3 ng/mL (95% CI −56.4, 1171.1; p=0.09) increase in cord blood VCAM1. Among mothers, the highest tertile of maternal urinary As during pregnancy was related to a 141.8 ng/mL (95% CI 26.1, 257.5; p=0.02) increase maternal plasma VCAM1 levels. Urinary As was unrelated to MCP1 or TNFα in maternal plasma and cord blood. In structural equation models, the association between maternal urinary As and infant VCAM was mediated by maternal levels of VCAM (βmediation: 0.024, 95% CI: 0.002, 0.050). Conclusion Our observations indicate that As exposure during pregnancy may affect markers of vascular health and endothelial function in both pregnant women and children, and suggest further investigation of the potential impacts on cardiovascular health in these susceptible populations.

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“…There are many risks associated with arsenic exposure including genotoxicity and neurotoxicity [Rocha‐Amador et al, ; Tyler and Allan, ; Jasso‐Pineda et al, ]. Exposure to this metalloid also represents a risk for metabolic disorders [Osorio‐Yáñez et al, and ; Mendez et al, ], respiratory damage [Olivas‐Calderón et al, ; Recio‐Vega et al, ] and diabetes [Del Razo et al, ; Drobná et al, ] at exposure levels comparable to those used in the present study. The carcinogenic potential of arsenic should be considered in exposure scenarios.…”

Section: Introductionmentioning

confidence: 99%

DNA methylation changes in Mexican children exposed to arsenic from two historic mining areas in San Luis potosí

Alegría-Torres

Carrizales-Yáñez

Dı́az-Barriga

et al. 2016

Environ and Mol Mutagen

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Arsenic is a carcinogen and epimutagen that threatens the health of exposed populations worldwide. In this study, we examined the methylation status of Alu and long interspersed nucleotide elements (LINE-1) and their association with levels of urinary arsenic in 84 Mexican children between 6 and 12 years old from two historic mining areas in the State of San Luis Potosí, Mexico. Urinary arsenic levels were determined by atomic absorption spectrophotometry and DNA methylation analysis was performed in peripheral blood leukocytes by bisulfite-pyrosequencing. The geometric mean of urinary arsenic was 26.44 µg/g Cr (range 1.93-139.35). No significant differences in urinary arsenic or methylation patterns due to gender were observed. A positive correlation was found between urinary arsenic and the mean percentage of methylated cytosines in Alu sequences (Spearman correlation coefficient r = 0.532, P < 0.001), and a trend of LINE-1 hypomethylation was also observed (Spearman correlation coefficient r = -0.232, P = 0.038) after adjustment for sex and age. A linear regression model showed an association with log-normalized urinary arsenic for Alu (β = 1.05, 95% CI: 0.67; 1.43, P < 0.001) and LINE-1 (β = -0.703, 95% CI: -1.36; -0.38, P = 0.038). Despite the low-level arsenic exposure, a subtle epigenetic imbalance measured as DNA methylation was detected in the leukocytes of Mexican children living in two historic mining areas. Environ. Mol. Mutagen. 57:717-723, 2016. © 2016 Wiley Periodicals, Inc.

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Blood Pressure, Left Ventricular Geometry, and Systolic Function in Children Exposed to Inorganic Arsenic

Cited by 34 publications

References 43 publications

Arsenic exposure assists ccm3 genetic polymorphism in elevating blood pressure

Arsenic exposure assists ccm3 genetic polymorphism in elevating blood pressure

Maternal and infant inflammatory markers in relation to prenatal arsenic exposure in a U.S. pregnancy cohort

DNA methylation changes in Mexican children exposed to arsenic from two historic mining areas in San Luis potosí

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