Blood pressure lowering, antidyslipidemic and nitric oxide modulatory effects of methanol extract of struchium sparganophora leaves on dexamethasone-salt model of hypertension in rats

Adeosun, Abiola Muhammad; Aroworamimo, Abdulrahman D.; Ighodaro, Osasenaga Macdonald; Asejeje, Folake Olubukola; Akinloye, Oluyemi

doi:10.1080/2314808x.2021.1961206

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…All induction dose groups demonstrated that dexamethasone and salt caused test animals to lose weight, this is consistent with research by Adeosun et al, 2021 and research that has been carried out by Filippopoulou et al, 2022 andEl-Sonbaty et al 2019 shows that dexamethasone lost weight in test rats and mice (Adeosun et al, 2021;El-Sonbaty et al, 2019;Filippopoulou et al, 2022). Another study conducted by Saganuwan et al, 2010 showed that giving salt solution to induce hypertension in rats can lose weight (El-Sonbaty et al, 2019).…”

Section: Resultssupporting

confidence: 82%

Dexamethasone and 5% NaCl Solution Induce Hypertension in Sparangue dawly Male Rats

Syafi’i

2022

fitofarmaka JIF

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High blood pressure can be caused by excess salt intake Dexamethasone is a potent anti-inflammatory drug, but the long-term administration can cause hypertension. This study aims to determine the accurate time and dose that cause hypertension in rat models by administration of a combination of dexamethasone and 5% NaCl solution. The control group was administrated with aquadest orally, 3 test groups were administrated with dexamethasone at a doses of 0.02mg/kg BW, 0.03mg/kg BW, and 0.5mg/kg BW intraperitonially (i.p) for 28 days. A 5% NaCl solution were administrated instead of drinking water to the test group. Blood pressure and body weight were measured weekly for 28 days. Results of the study show that Dexamethasone at a dose of 0.02mg/kg BW caused hypertension on day-28 where the rats blood pressure increase to 148mmHg/103mmHg (Â±1.9/Â±3.1) (P<0.05) compared to control rats and the weight decline by 90 grams. Dexamethasone 0.03mg/kg BW caused hypertension on day-21, with the increase of rats blood pressure at144mmHg/101mmHg (Â±2,6/Â±3.2) (P<0.05) compared to control and the weight decrease by 83 grams.Â Dexamethasone 0.5mg/kg BW caused hypertension on day-7, the rats blood pressure rise to 146mmHg/103mmHg (Â±1.6/1.9) (P<0.05) compared to control and the weight decrease by 69 grams. As conclusion, Dexamethasone at dose of 0.5mg/kg BW and NaCl 5% cause hypertension faster on day 14 compared to dexamethasone at dose of 0.02mg/kg BW and NaCl 5% which cause hypertension slower after 28 days of administration.

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Section: Resultssupporting

confidence: 82%

Dexamethasone and 5% NaCl Solution Induce Hypertension in Sparangue dawly Male Rats

Syafi’i

2022

fitofarmaka JIF

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“…In figure I, it was observed that the rats in Groups II, III, IV, V and VI showed decrease in body weight in week 1 of the experiment. This is in agreement with the studies by [31] and [35] who reported decrease in body weight of rats after administration of Dexamethasone but in contrast with the findings of [36], who reported increased body weight after administration of Dexamethasone-salt. In Group II, there was marked increase in body weight when the dexamethasone-salt inducing agent was withdrawn.…”

Section: Table 2: Mean Concentrations and Standard Deviation Of Serum...supporting

confidence: 93%

Comparative Effect of Lisinopril and Amlodipine with Moringa Oleifera on the Kidney Function of Dexamethasone and Salt-Induced Hypertensive Albino Rats

Bot,

Ukachi,

Emaina

et al. 2024

ejmhr

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Hypertension is one of the most common causes of death worldwide; and a common cause of cardiovascular and renal complications which can be frequent, chronic and age related. Use of antihypertensive drugs such as Lisinopril and Amlodipine which have no significant first pass effects, pose a threat to the kidney. This study aimed at comparing the effects of conventional antihypertensive drugs Lisinopril and Amlodipine with Moringa oleifera on the kidney of Albino rats using Urea and Creatinine as markers. A total of 30 Albino rats were divided into six groups. Group I served as negative control; Group II as positive control; Groups III, IV, V and VI were test groups. They were induced hypertension with Dexamethasone-salt and treated with 0.07mg/kg body weight Lisinopril, 0.27mg/kg Amlodipine and with 20mg/kg and 40mg/kg Moringa oleifera leaves capsules respectively. At the end of treatment which lasted for 3 weeks, the animals were sacrificed and blood samples collected into clean-dry containers and serum harvested; and used to measure the levels of Urea and Creatinine with Chemistry auto-analyzer (COBAS C111). Data obtained were analysed using statistical package for the social sciences (IBM-SPSS) version 27.0. The results indicated no significant increase in serum Urea and insignificant decrease in Creatinine in all the treatment groups. This indicates synergy in these classes of antihypertensive drugs and Moringa at the said concentrations. Based on these results, it can be concluded that Moringa oleifera leaves extract could be used complementarily with Lisinopril and Amlodipine for treatment and management of hypertension.

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Blood pressure lowering, antidyslipidemic and nitric oxide modulatory effects of methanol extract of struchium sparganophora leaves on dexamethasone-salt model of hypertension in rats

Cited by 2 publications

References 27 publications

Dexamethasone and 5% NaCl Solution Induce Hypertension in Sparangue dawly Male Rats

Dexamethasone and 5% NaCl Solution Induce Hypertension in Sparangue dawly Male Rats

Comparative Effect of Lisinopril and Amlodipine with Moringa Oleifera on the Kidney Function of Dexamethasone and Salt-Induced Hypertensive Albino Rats

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