Blood pressure-lowering effect of fish oil is independent of thromboxane A2 level in spontaneously hypertensive rats

Chen, H.W.; Lii, Chong‐Kuei; Chen, W.T.; Wang, M.L.; Ou, Chu‐Chyn

doi:10.1016/s0952-3278(96)90072-1

Cited by 22 publications

(13 citation statements)

References 59 publications

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“…In addition, studies using animal models have shown that fish oil has a generalized blood pressure–lowering effect 57. Nevertheless, as with atherosclerosis, the individual effects of n3FAs in hypertension are less studied.…”

Section: Discussionmentioning

confidence: 99%

Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL‐1–Mediated Mechanism

Alfaidi

Chamberlain

Rothman

et al. 2018

JAHA

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BackgroundHypertension is a complex condition and a common cardiovascular risk factor. Dietary docosahexaenoic acid (DHA) modulates atherosclerosis and hypertension, possibly via an inflammatory mechanism. IL‐1 (interleukin 1) has an established role in atherosclerosis and inflammation, although whether IL‐1 inhibition modulates blood pressure is unclear.Methods and ResultsMale apoE−/− (apolipoprotein E–null) mice were fed either a high fat diet or a high fat diet plus DHA (300 mg/kg per day) for 12 weeks. Blood pressure and cardiac function were assessed, and effects of DHA on wall shear stress and atherosclerosis were determined. DHA supplementation improved left ventricular function, reduced wall shear stress and oscillatory shear at ostia in the descending aorta, and significantly lowered blood pressure compared with controls (119.5±7 versus 159.7±3 mm Hg, P<0.001, n=4 per group). Analysis of atheroma following DHA feeding in mice demonstrated a 4‐fold reduction in lesion burden in distal aortas and in brachiocephalic arteries (P<0.001, n=12 per group). In addition, DHA treatment selectively decreased plaque endothelial IL‐1β (P<0.01).ConclusionsOur findings revealed that raised blood pressure can be reduced by inhibiting IL‐1 indirectly by administration of DHA in the diet through a mechanism that involves a reduction in wall shear stress and local expression of the proinflammatory cytokine IL‐1β.

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Section: Discussionmentioning

confidence: 99%

Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL‐1–Mediated Mechanism

Alfaidi

Chamberlain

Rothman

et al. 2018

JAHA

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“…LA, which is present in lower amounts in flaxseed oil, is a precursor molecule for the synthesis of arachidonic acid (AA) [17]. Some reports have demonstrated that EPA and DHA prevent the development of hypertension [18,19] and exhibit anti-atherothrombogenic effects [20]. These effects might be induced, at least in part, through a decrease in TXA 2 and an increase in PGI 3 in vessels, such as the aorta [10-12].…”

Section: Discussionmentioning

confidence: 99%

Flaxseed oil increases aortic reactivity to phenylephrine through reactive oxygen species and the cyclooxygenase-2 pathway in rats

et al. 2014

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BackgroundFlaxseed oil has the highest concentration of omega-3 α-linolenic acid, which has been associated with cardiovascular benefit. However, the mechanism underlying the vascular effects induced through flaxseed oil is not well known. Thus, in the present study, we investigated the effects of flaxseed oil on vascular function in isolated rat aortic rings.MethodsWistar rats were treated daily with flaxseed oil or a control (mineral oil) intramuscular (i.m.) for fifteen days. Isolated aortic segments were used to evaluate cyclooxygenase-2 (COX-2) protein expression, superoxide anion levels and vascular reactivity experiments.ResultsFlaxseed oil treatment increased the vasoconstrictor response of aortic rings to phenylephrine. Endothelium removal increased the response to phenylephrine in aortic segments isolated from both groups, but the effect was smaller in the treated group. L-NAME incubation similarly increased the phenylephrine response in segments from both groups. The TXA2 synthase inhibitor furegrelate, the selective COX-2 inhibitor NS 398, the TP receptor antagonist SQ 29.548, the reactive oxygen species (ROS) scavenger apocynin, the superoxide anion scavengers tiron and the phospholipase A2 inhibitor dexamethasone partially reversed the flaxseed oil-induced increase in reactivity to phenylephrine.ConclusionsThese findings suggest that flaxseed oil treatment increased vascular reactivity to phenylephrine through an increase in ROS production and COX-2-derived TXA2 production. The results obtained in the present study provide new insight into the effects of flaxseed oil treatment (i.m.) on vascular function.

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“…2004). In particular, these substances have been reported to lower blood pressure and prevent the development of hypertension, which is one of the most critical factors involved in cardiovascular pathologies such as atherosclerosis or stroke (Chen et al. 1996; Prisco et al.…”

Section: Introductionmentioning

confidence: 99%

“…2001). Dietary supplementation with these fatty acids has provided evidence of their cardiovascular protective effects and their ability to lower blood pressure (Chen et al. 1996; Prisco et al.…”

Section: Introductionmentioning

confidence: 99%

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The role of docosahexaenoic acid on visual evoked potentials in one kidney‐one clip hypertension

Hacioglu

Ağar

Yargiçoğlu

2006

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To investigate the effects of polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) on visual evoked potentials (VEPs) in a one kidney-one clip (1K-1C) hypertension model in rats. Methods: Five experimental groups were formed: a control group, a sham group, a group supplemented with DHA, a 1K-1C group, and a 1K-1C + DHA group. The DHA groups were treated for 60 days. In the 1K-1C groups, the right kidney was removed and a silver clip with a 0.2-mm gap was placed on the left renal artery. Results: The DHA-supplemented rats had lower blood pressure than their respective controls (p < 0.01). The increased brain and retina thiobarbituric acid reactive substances (TBARS) levels in hypertensive rats were abolished by DHA administration. The brain nitrite levels were lower in the DHA, 1K-1C and 1K-1C + DHA groups compared with the control group (p < 0.01), and the retina nitrite level was higher in the 1K-1C + DHA group compared with the DHA and 1K-1C groups (p < 0.01). There was an improvement of P 2 , N 2 and P 3 components following DHA supplementation in 1K-1C hypertensive rats compared with the 1K-1C group. Conclusion: The present study suggests that DHA supplementation has the potential to prevent VEP changes caused by an experimental model of hypertension. This state might be related to the lipid peroxidation lowering effect of DHA.

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Blood pressure-lowering effect of fish oil is independent of thromboxane A2 level in spontaneously hypertensive rats

Cited by 22 publications

References 59 publications

Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL‐1–Mediated Mechanism

Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL‐1–Mediated Mechanism

Flaxseed oil increases aortic reactivity to phenylephrine through reactive oxygen species and the cyclooxygenase-2 pathway in rats

The role of docosahexaenoic acid on visual evoked potentials in one kidney‐one clip hypertension

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