2020
DOI: 10.1007/s40256-020-00423-z
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Blood Pressure-Lowering Effect of Newer Antihyperglycemic Agents (SGLT-2 Inhibitors, GLP-1 Receptor Agonists, and DPP-4 Inhibitors)

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Cited by 33 publications
(27 citation statements)
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“…Some evidence suggested that GLP-1 agonists and DPP-4i can influence the hemodynamic state and modify BP [55][56][57]. We have reviewed all possible mechanisms associated with this class of agents and hemodynamics in the following sections (Table 1).…”
Section: Possible Links Between Glp-1ra and Ddp-4i And Blood Pressurementioning
confidence: 99%
“…Some evidence suggested that GLP-1 agonists and DPP-4i can influence the hemodynamic state and modify BP [55][56][57]. We have reviewed all possible mechanisms associated with this class of agents and hemodynamics in the following sections (Table 1).…”
Section: Possible Links Between Glp-1ra and Ddp-4i And Blood Pressurementioning
confidence: 99%
“…[4] Among them, DPP-4 has recently become a hot research topic in the development of hypoglycaemic drugs which was used for the treatment of type 2 diabetes, which can inhibit the inactivation of glucagonlike peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), improving the levels of endogenous GLP-1 and promoting the release of insulin from pancreatic β cells by GIP and it can also inhibit the secretion of glucagon from pancreatic α cells, thereby increasing the insulin levels and lowering the blood sugar. [5] At present, there are 12 kinds of DPP-4 inhibitors that have entered the market, and 4 drugs are in the clinical research stage and many new small DPP-4 inhibitors are in the preclinical research stage. [6] The biggest advantage of antidiabetic drugs targeting DPP-4 is not easy to induce hypoglycemia and weight gain.…”
Section: Introductionmentioning
confidence: 99%
“…Dipeptidyl peptidase-4 (DPP-4) is a kind of serine proteinase mainly expressed in small intestine, liver, kidney, pancreas and spleen. In vivo, it can resolve GLP-1, resulting in the decreasing of insulin secretion and the occurrence of diabetes [1][2][3]. DPP-4 has become a hot target in the development of hypoglycemic drugs recently.…”
Section: Introductionmentioning
confidence: 99%