Blood pressure lowering efficacy of reserpine for primary hypertension

Shamon, Sandy D; Perez, Marco I

doi:10.1002/14651858.cd007655.pub2

Cited by 15 publications

(6 citation statements)

References 40 publications

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“…Reserpine is a natural alkaloid isolated from Rauwolfia serpentine (Shamon and Perez 2009; Huffman and Stern 2007), which depletes monoamines by irreversibly blocking their vesicular monoamine transporter (VMAT) (Erickson et al 1992). In humans, this agent generally induces antipsychotic, calming (tranquilizing) and pro-depressant effects (Quetsch et al 1959; Freis 1954; Baumeister et al 2003; Estes 1995; Bigelow 2006; Yaniv and Bachrach 2005).…”

Section: Introductionmentioning

confidence: 99%

“…In rodents, reserpine causes hypoactivity (Williams and Pirch 1974), motor stereotypies (Neisewander et al 1991), akinesia (Dolphin et al 1976), lethargy (Sigg et al 1965) and anhedonia (Skalisz et al 2002), relevant to depression (Borison et al 1978; Lee et al 2012) and Parkinson’s disease (PD) (Duty and Jenner 2011). The drug also exerts conflicting action on clinical (Shamon and Perez 2009; Sarwer-Foner and Ogle 1956; Starkweather 1959) and animal anxiety, including no effects (Angrini et al 1998; Heslop and Curzon 1999), increased (Angrini et al 1998; Heslop and Curzon 1999; Haggendal and Lindqvist 1963; Ahlenius and Salmi 1994; LaBuda and Fuchs 2002) or reduced anxiety (Xu et al 1992) (also see tranquilizing effects is some fish species (Turner and Carl 1955; Cano 1959)).…”

Section: Introductionmentioning

confidence: 99%

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Behavioral effects of bidirectional modulators of brain monoamines reserpine and d-amphetamine in zebrafish

Kyzar¹,

Stewart

Landsman³

et al. 2013

Brain Research

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Brain monoamines play a key role in the regulation of behavior. Reserpine depletes monoamines, and causes depression and hypoactivity in humans and rodents. In contrast, d-amphetamine increases brain monoamines’ levels, and evokes hyperactivity and anxiety. However, the effects of these agents on behavior and in relation to monoamine levels remain poorly understood, necessitating further experimental studies to understand their psychotropic action. Zebrafish (Danio rerio) are rapidly emerging as a promising model organism for drug screening and translational neuroscience research. Here, we have examined the acute and long-term effects of reserpine and d-amphetamine on zebrafish behavior in the novel tank test. Overall, d-amphetamine (5 and 10 mg/L) evokes anxiogenic-like effects in zebrafish acutely, but not 7 days later. In contrast, reserpine (20 and 40 mg/L) did not evoke overt acute behavioral effects, but markedly reduced activity 7 days later, resembling motor retardation observed in depression and/or Parkinson’s disease. Three-dimensional ‘temporal’ (X, Y, Time) reconstructions of zebrafish locomotion further supports these findings, confirming the utility of 3D-based video-tracking analyses in zebrafish models of drug action. Our results show that zebrafish are highly sensitive to drugs bi-directionally modulating brain monoamines, generally paralleling rodent and clinical findings. Collectively, this emphasizes the potential of zebrafish tests to model complex brain disorders associated with monoamine dysregulation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Behavioral effects of bidirectional modulators of brain monoamines reserpine and d-amphetamine in zebrafish

Kyzar¹,

Stewart

Landsman³

et al. 2013

Brain Research

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“…Rauwolfia contains an alkaloid reserpine, which reduces blood pressure,[1314] depresses activity of the CNS[15] by depleting catecholamines and serotonin, and acts as a hypnotic. [1617] Although the utility of Rauwolfia in cardiovascular disorders has been premiered by Vakil, its utility in mental illnesses can be said to have been popularized by Dr. R. A. Hakim from Ahmedabad, Gujarat, who studied the effects of ‘ Siledin ’, a mixture of medicinal plants, including Rauwolfia , and found it effective in schizophrenic and manic-depressive disorders.…”

Section: Role Of Rauwolfiamentioning

confidence: 99%

Mutual learning and research messages: India, UK, and Europe

Kalra

Bhugra

2010

Indian J Psychiatry

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India and UK have had a long history together, since the times of the British Raj. Most of what Indian psychiatry is today, finds its roots in ancient Indian texts and medicine systems as much as it is influenced by the European system. Psychiatric research in India is growing. It is being influenced by research in the UK and Europe and is influencing them at the same time. In addition to the sharing of ideas and the know-how, there has also been a good amount of sharing of mental health professionals and research samples in the form of immigrants from India to the UK. The Indian mental health professionals based in UK have done a good amount of research with a focus on these Indian immigrants, giving an insight into cross-cultural aspects of some major psychiatric disorders. This article discusses the impact that research in these countries has had on each other and the contributions that have resulted from it.

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“…2 Reserpine (RSP), an alpha-2 agonist, inhibits the uptake of norepinephrine into storage vesicles, resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. 3 Valsartan (VST), an angiotensin II receptor antagonist, lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system and competes with angiotensin II for binding to the type-1 angiotensin II receptor subtype and prevents the blood pressure increasing effects of angiotensin II. 4 Taking these antihypertensive chemicals without doctor's guidance would result in serious consequences, such as reduction of the total blood volume, leading to the risk of hypotension, even collapse and the increase of blood viscosity with the risk of thrombosis.…”

Section: Introductionmentioning

confidence: 99%