Blood pressure-lowering efficacy of reserpine for primary hypertension

Shamon, Sandy D; Perez, Marco I

doi:10.1002/14651858.cd007655.pub3

Cited by 64 publications

(46 citation statements)

References 52 publications

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“…Reserpine, a drug for the control of high blood pressure and for the relief of psychotic symptoms, was isolated from R vomitoria. [32][33][34] Extracts from the root bark of this plant, from which reserpine has been removed, are enriched with β-carboline alkaloids. 35,36 β-Carboline alkaloids have been previously reported to demonstrate many bioactivities, including antitumor effects.…”

Section: Introductionmentioning

confidence: 99%

Antitumor Activities of Rauwolfia vomitoria Extract and Potentiation of Gemcitabine Effects Against Pancreatic Cancer

Chen

2014

Integr Cancer Ther

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Pancreatic cancer is one of the most lethal malignancies with very limited treatment option. In the effort of enhancing the effect of the conventional chemotherapeutic drug gemcitabine against pancreatic cancer, we investigated in vitro and in vivo the anticancer effect of a β-carboline-enriched extract from the plant Rauwolfia vomitoria (Rau), either alone or in combination with gemcitabine, in preclinical pancreatic cancer models. Rau induced apoptosis in pancreatic cancer cells in a concentration-dependent manner, and completely inhibited colony formation of PANC-1 cells in soft agar. The combination of Rau and gemcitabine had synergistic effect in inhibiting cell growth with dose reduction effect for gemcitabine. In an orthotopic pancreatic cancer mouse model, PANC-1 tumor growth was significantly suppressed by Rau treatment. Metastasis was inhibited by Rau. Adding Rau to gemcitabine treatment reduced tumor burden and metastatic potential in the gemcitabine non-responsive tumor. These data suggest that Rau possesses anti-pancreatic cancer activity and could improve effect of gemcitabine.

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Section: Introductionmentioning

confidence: 99%

Antitumor Activities of Rauwolfia vomitoria Extract and Potentiation of Gemcitabine Effects Against Pancreatic Cancer

Chen

2014

Integr Cancer Ther

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“…[86,87] Thereafter, effect of reserpine in the vasomotor center causes diminished reflex in vasomotor responses leading to generalized vasodilatation, with a lowering of blood pressure. [86] Rescinnamine Rescinnamine binds and inhibits angiotensin converting enzyme and competes with Angiotensin I thus, blocking the conversion of Angiotensin I-II. [88] Angiotensin II is a negative feedback mediator of renin activity and a vasoconstrictor [ Figure 3].…”

Section: Reserpinementioning

confidence: 99%

Untitled

Singh

2017

IJGP

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Rauwolfia serpentina is reported in an Ayurvedic medicinal system for centuries, for the treatment of various ailments such as snakebites, insomnia, hypertension, and insanity. Scientific evaluation of these documents can be valuable for finding new potential use in neurological disorders. The work presents the brief overview of R. serpentina including a description of the plant, its active chemical constituents and pharmacological properties with the major emphasis on cardiovascular and central nervous system disorders. This review compiles information available in the scientific literature from databases such as Science Direct, PubMed, India bioscience. org, Herbs -Medicinal plant usage and Identification Database, Database on medicinal plants used in Ayurveda and Siddha, Missouri Botanical Garden, National Medicinal Plants Board, and the International Plant Names Index. Information gathered from the literature has shown that the alkaloids are the major constituents of the plant imparting various pharmacological properties. Reserpine, the Indole alkaloid, is the most active compound of R. serpentine. The plant is known to possess antidiarrheal, antimicrobial activity apart from using it for the treatment of circulatory disorders, rheumatism, hypertension, insanity, epilepsy, and leaves are used in the removal of opacities of the cornea. Research shows that R. serpentine is a potential source of compounds pertaining medicinal applications. It provides an interesting subject in the search for new drugs of natural origin.

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“…Several clinical studies have demonstrated the use of reserpine, an alkaloid isolated form R. serpentine as an anti-hypertensive and it is also used clinically for treatment of hypertension (Freis and Ari, 1954;Shamon and Perez, 2009). A 2-year double blind study conducted on patients with essential hypertension showed a significant fall of SBP and DBP in the patients receiving the treatment (Sheldon and Kotte, 1957).…”

Section: Rauwolfia Serpentine (Rauwolfia)mentioning

confidence: 99%

“…Apocynaceae Reserpine alkaloid India, Thialand, Sri Lanka, Burma, and Indonesia, Pacific, South America, Africa Vasodilation mediated through action on vasomotor system (Freis and Ari, 1954;Sheldon and Kotte, 1957;Gawade and Fegade, 2012;Shamon and Perez, 2009;Asgary, Naderi, 2000) 15…”

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confidence: 99%