Blood Pressure, Perfusion Pressure, and Open-Angle Glaucoma: The Los Angeles Latino Eye Study

Memarzadeh, Farnaz; Ying-Lai, Mei; Chung, Jessica; Azen, Stanley P.; Varma, Rohit

doi:10.1167/iovs.08-2956

Cited by 208 publications

(216 citation statements)

References 24 publications

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“…18 This biofeedback system prevents hypotension via the regulation of the ultrafiltration rate and facilitates the protection of the optic nerve from the hazardous effects of hypotension, which can offer protection against ischemia and reperfusion damage in glaucoma patients and individuals prone to glaucoma. 19 Aqueous humor dynamics in a glaucomatous eye differs from the normal eye. This difference is mainly related to the outflow pathways.…”

Section: Discussionmentioning

confidence: 99%

The effect of hemodialysis on intraocular pressure

Kilavuzoglu¹,

Yurteri²,

Guven³

et al. 2018

Adv Clin Exp Med

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Section: Discussionmentioning

confidence: 99%

The effect of hemodialysis on intraocular pressure

Kilavuzoglu¹,

Yurteri²,

Guven³

et al. 2018

Adv Clin Exp Med

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“…Subjects were excluded if they met one of the following criteria: (1) presence of retinal disease; (2) previous ocular surgery; (3) family history of glaucoma; (4) best-corrected visual acuity o20/40; (5) IOP of 22 mm Hg or greater; (6) refractive error exceeding a spherical equivalent of 9 diopters or astigmatism of 2 diopters; (7) trabecular meshwork not visible in any quadrant on static gonioscopy; or (8) glaucomatous optic disc changes, such as excavation, thinning, or notching of the neuroretinal rim, and disc hemorrhages.…”

Section: Methodsmentioning

confidence: 99%

“…1,2 In addition to elevated IOP, factors such as ocular blood flow, 3 racial factors, 4 refractive errors, 5 genetic factors, 4 and low cerebrospinal fluid pressure 6 have been associated with the glaucoma pathogenesis. However, IOP is the only modifiable risk factor; IOP lowering is the only proven therapy to prevent or slow down the development or progression of glaucoma.…”

Section: Introductionmentioning

confidence: 99%

Effects of head elevation on intraocular pressure in healthy subjects: raising bed head vs using multiple pillows

et al. 2014

Eye

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Purpose To evaluate the effects of different methods of head elevation on intraocular pressure (IOP) in healthy young subjects. Methods Twenty-four healthy young Korean subjects were included in this prospective observational study. The IOP measurements were taken with the subjects in the sitting position and in the supine positions with the head flat and 301 up using two different methods: (1) raising the bed head and (2) using multiple pillows. IOP was measured using Tonopen AVIA in both eyes 10 min after assuming each position in a randomized sequence. The Wilcoxon signed-rank test was used to compare the IOP by changing the methods of head elevation. Results Mean IOP of both eyes when sitting was lower than that measured in the supine position with head flat (P ¼ 0.001). Compared with that measured in the supine position with head flat, the mean IOP was lower when measured in the supine position with the head kept 30 1 up by bed head elevation (P ¼ 0.001), whereas the mean IOP was not significantly different when measured in the supine position with the head elevated using multiple pillows (right eye, P ¼ 0.061; left eye, P ¼ 0.089). Conclusion In normal subjects, IOP was lower when measured in the supine position with the head kept up by the bed head elevation compared with that measured when lying flat. However, such head-up positioninduced IOP reduction was not found when the head was kept up using multiple pillows. These findings suggest that elevating the head using multiple pillows may not help to reduce IOP in the supine posture.

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“…Higher systolic and mean arterial blood pressures were associated with a higher prevalence of POAG in the Los Angeles eye study. [27] The Blue Mountains Eye Study, the Egna-Neumarkt glaucoma study and the Rotterdam Eye Study also found that systemic HTN increases the susceptibility to glaucoma, possibly due to a positive correlation between blood pressure and IOP. [28][29][30] Despite this positive correlation, the actual change in IOP with increasing blood pressure is small.…”

Section: Discussionmentioning

confidence: 97%

Efficacy and safety of timolol and latanoprost in the treatment of primary open-angle glaucoma

Ratnala¹,

Jayanthi²,

Sujatha³

2017

Natl J Physiol Pharm Pharmacol

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Background: Glaucoma is a chronic, progressive optic neuropathy which leads to optic nerve damage and loss of visual function. Elevated intraocular pressure (IOP) is the most important and only modifiable risk factor. Hence, the goal of glaucoma therapy is to lower IOP, and ocular hypotensive agents have the potential to prevent optic nerve damage and preserve vision. Aims and Objectives: Aims and objectives of the study are to compare the efficacy and safety of timolol 0.5% versus latanoprost 0.005% in the treatment of primary open-angle glaucoma (POAG). Materials and Methods: A total of 60 newly diagnosed patients of POAG who fulfilled the inclusion/exclusion criteria were enrolled and randomized into two groups of 30 each to receive timolol 0.5% twice daily and latanoprost 0.005% once daily in the evening. IOP was recorded at baseline and each follow-up visit. The patients were followed every 4 weeks for 12 weeks. Adverse effects, if any, were also recorded at each visit. Results: At 12 weeks both timolol and latanoprost effectively reduced IOP, but the reduction was significantly greater (P < 0.0001) with latanoprost (7.97 ± 1.27 mmHg, 31.25%) compared with timolol (6.77 ± 1.48 mmHg, 25.9%). More number of eyes (χ 2 = 4.6, df = 1, P = 0.032) treated with latanoprost (46, 76.6%) achieved a specific target IOP as compared to those treated with timolol (35, 58.3%). Both the study medications were well tolerated. Conclusion: Latanoprost was found to be more potent and efficacious in reducing IOP with good tolerability in patients with POAG.

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Blood Pressure, Perfusion Pressure, and Open-Angle Glaucoma: The Los Angeles Latino Eye Study

Abstract: Low diastolic, systolic and mean perfusion pressures, low diastolic blood pressure, and high systolic and mean arterial blood pressures are associated with a higher prevalence of OAG in adult Latinos.

Cited by 208 publications

References 24 publications

The effect of hemodialysis on intraocular pressure

The effect of hemodialysis on intraocular pressure

Effects of head elevation on intraocular pressure in healthy subjects: raising bed head vs using multiple pillows

Efficacy and safety of timolol and latanoprost in the treatment of primary open-angle glaucoma

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