Blood Pressures of Rats Subjected to Auditory Stimulation

Yeakel, Eleanor H.; Shenkin, Henry A.; Rothballer, Alan B.; McCann, Samuel M.

doi:10.1152/ajplegacy.1948.155.1.118

Cited by 33 publications

(12 citation statements)

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“…9], The present investigation demonstrated that chronic (longer than 3 weeks) noise exposure induced an increment of systolic blood pressure. This was consistent with previous reports in which noise stress induces significant elevation in blood pressure in rats [2,3,16,18], In one study, exposure to acute noise was accompanied by elevated plasma angiotensin levels which were thought to contribute to the elevated blood pressure [7], In addition, several reports indicate that noise-induced stress results in the release into the blood stream of various stress hormones. Most of these changes are transient and do not seem to be associated with the noise-induced sustained elevation of arterial blood pressure [1,6], The mechanism responsible for the release of these hormones has not been ascertained.…”

Section: Effects Of Methylene Blue or Nm-nitro-l-arginine On Ach-lndusupporting

confidence: 91%

“…Extended exposure to intense noise or prolonged expo sure to noise is known to induce chemical and physiologi cal disturbances of the endocrine, cardiovascular and ner vous systems, in addition to its effects on audition [11], Several studies point to a relationship between noise expo sure and elevated peripheral vascular resistance and between noise exposure and elevated blood pressure in the human [2,9], Investigations with rats have also indicated that noise exposure may contribute to elevated blood pres sure [3,18]. nitro-L-arginine (Sigma), methylene blue (Sigma).…”

Section: Introductionmentioning

confidence: 99%

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Attenuation of Endothelium- Dependent Relaxation in Mesenteric Artery during Noise- Induced Hypertension

Chen

Yen³

1994

J Biomed Sci

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The present study was designed to determine whether there is a causal relationship between noise-induced hypertension and changes of endothelial function. Rats were exposed to noise stress (100 dB. 1 kHz, 4 h/day, 6 days/week) for 1-4 weeks. The systolic blood pressure was significantly increased after rats were exposed to noise stress for 3 weeks. The relaxant responses of isolated mesenteric arterial rings to endothelium-dependent vasodilators (A23187 and acetylcholine) in noise-treated rats were significantly less than those in control rats. This difference in response to acetylcholine still existed in the presence of methylene blue or N^(l)-nitro-L-arginine. On the other hand, the responses to the endothelium-independent vasodilator nitroglycerin were not affected in rats exposed to noise stress. The attenuation to endothelium-dependent vasodilators during noise stress may result in increasing peripheral vascular resistance and thus elevate blood pressure. This indicates that noise-induced hypertension may be partly due to the alterations of endothelial activity.

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Section: Effects Of Methylene Blue or Nm-nitro-l-arginine On Ach-lndusupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Attenuation of Endothelium- Dependent Relaxation in Mesenteric Artery during Noise- Induced Hypertension

Chen

Yen³

1994

J Biomed Sci

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“…13 Noise is associated with activation of the sympathetic nervous system. 14 In animal models, chronic exposure to noise leads to increases in blood pressure, 15 16 and in humans noradrenaline (norepinephrine) levels, 17 whereas acute exposure to non-habitual loud noise increases adrenaline (epinephrine) levels. 17 Experimental studies of humans acutely exposed to noise at very high level also show increases in blood pressure 18 and heart rate.…”

Section: Introductionmentioning

confidence: 99%

Aircraft noise and cardiovascular disease near Heathrow airport in London: small area study

Hansell

Blangiardo

Fortunato

et al. 2013

BMJ

217

169

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Objective To investigate the association of aircraft noise with risk of stroke, coronary heart disease, and cardiovascular disease in the general population.Design Small area study.Setting 12 London boroughs and nine districts west of London exposed to aircraft noise related to Heathrow airport in London.Population About 3.6 million residents living near Heathrow airport. Risks for hospital admissions were assessed in 12 110 census output areas (average population about 300 inhabitants) and risks for mortality in 2378 super output areas (about 1500 inhabitants).Main outcome measures Risk of hospital admissions for, and mortality from, stroke, coronary heart disease, and cardiovascular disease, 2001-05.Results Hospital admissions showed statistically significant linear trends (P<0.001 to P<0.05) of increasing risk with higher levels of both daytime (average A weighted equivalent noise 7 am to 11 pm, L Aeq,16h ) and night time (11 pm to 7 am, L night ) aircraft noise. When areas experiencing the highest levels of daytime aircraft noise were compared with those experiencing the lowest levels (>63 dB v ≤51 dB), the relative risk of hospital admissions for stroke was 1.24 (95% confidence interval 1.08 to 1.43), for coronary heart disease was 1.21 (1.12 to 1.31), and for cardiovascular disease was 1.14 (1.08 to 1.20) adjusted for age, sex, ethnicity, deprivation, and a smoking proxy (lung cancer mortality) using a Poisson regression model including a random effect term to account for residual heterogeneity. Corresponding relative risks for mortality were of similar magnitude, although with wider confidence limits. Admissions for coronary heart disease and cardiovascular disease were particularly affected by adjustment for South Asian ethnicity, which needs to be considered in interpretation. All results were robust to adjustment for particulate matter (PM 10 ) air pollution, and road traffic noise, possible for London boroughs (population about 2.6 million). We could not distinguish between the effects of daytime or night time noise as these measures were highly correlated. ConclusionHigh levels of aircraft noise were associated with increased risks of stroke, coronary heart disease, and cardiovascular disease for both hospital admissions and mortality in areas near Heathrow airport in London. As well as the possibility of causal associations, alternative explanations such as residual confounding and potential for ecological bias should be considered. IntroductionAlthough the literature on population annoyance associated with aircraft noise is extensive, 1 2 little research has been conducted on the potential effects of aircraft noise on cardiovascular health.2 Most studies of the health effects associated with aircraft noise have focused on blood pressure and the risk of hypertension. [3][4][5][6][7][8] The few reports of aircraft noise and risk of stroke, coronary heart disease, or cardiovascular disease are inconsistent, 9-12 partly reflecting reduced statistical power Noise levels show a graded, direct re...

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“…Previous animal studies, mainly in rats, have shown acute rises of BP during stimulation with noise (12. 19). Repeated exposure of animals to alerting stimuli has also been shown to produce a permanent elevation of BP (3,16).…”

mentioning

confidence: 99%

Noise as a Contributory Factor in the Development of Elevated Arterial Pressure

Andrén¹,

Hansson²,

Björkman³

et al. 1980

Journal of Internal Medicine

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ABSTRACT. Arterial pressure and other hemodynamic variables (stroke volume (SV), cardiac output and total peripheral resistance) were studied in 18 healthy males before and during exposure to recorded industrial noise. All measurements took place under strictly standardized conditions in a noise laboratory. The frequency distribution and level of noise used for stimulation were continuously monitored and kept constant within close limits throughout the experiments. SV was measured with impedance cardiography. Indirect blood pressure (BP) in the brachial artery was measured with an automatic device and the derived parameters, cardiac output and total peripheral resistance, were calculated from these measurements. Compared with resting conditions at 40 dBA, stimulation with industrial noise at 95 dBA caused significant increases in diastolic BP, mean arterial pressure and total peripheral resistance. Minor but statistically significant reductions of SV and cardiac output were seen. Heart rate and systolic BP did not change. These alterations of the hemodynamic variables persisted throughout 20 min of noise stimulation and were maintained for 5 min following cessation of noise stimulation. All variables had returned to their initial levels 10 min after discontinuation of noise stimulation. This study suggests that exposure to industrial noise at levels prevailing during several industrial processes may cause acute elevations of arterial BP and peripheral vascular resistance. In animal studies, repeated elevations of BP due to exposure to noise have been shown to cause a permanent elevation of BP. Therefore, we suggest that noise may be one of several external stimuli contributing to the development of arterial hypertension in man.

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Blood Pressures of Rats Subjected to Auditory Stimulation

Cited by 33 publications

References 0 publications

Attenuation of Endothelium- Dependent Relaxation in Mesenteric Artery during Noise- Induced Hypertension

Attenuation of Endothelium- Dependent Relaxation in Mesenteric Artery during Noise- Induced Hypertension

Aircraft noise and cardiovascular disease near Heathrow airport in London: small area study

Noise as a Contributory Factor in the Development of Elevated Arterial Pressure

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