Blood prime for patients with single‐needle access requiring extracorporeal photopheresis: How to do and why it may be useful

The apheresis management of patients undergoing transplantation: a concise review

“…Nonetheless, there is significant variation in duration based on improvement of the patient's laboratory data and clinical symptoms . ECP may require procedural adjustments such as priming with red blood cells (RBCs) for patients with a low body weight and/or anemia to compensate for a large extracorporeal volume during the procedure . Although it is unknown if a specific minimum amount of MNCs are required for a treatment benefit, it has been suggested that MNCs should be detectable in the peripheral blood before processing approximately 1500 mL of whole blood (as usually determined by the machine and its manufacturer) …”

“…5 ECP may require procedural adjustments such as priming with red blood cells (RBCs) for patients with a low body weight and/or anemia to compensate for a large extracorporeal volume during the procedure. 11 Although it is unknown if a specific minimum amount of MNCs are required for a treatment benefit, it has been suggested that MNCs should be detectable in the peripheral blood before processing approximately 1500 mL of whole blood (as usually determined by the machine and its manufacturer). 5 Pretransplant desensitization with TPE can reduce rejection risk by decreasing preformed DSAs to an acceptable threshold of antibody titer.…”