Blood Profile and Histology in Oral Infections Associated with Diabetes

Cintra, Luciano Tavares Ângelo; Facundo, Aguinaldo Cândido da Silva; Prieto, Annelise Katrine Carrara; Sumida, Dóris Hissako; Narciso, Luı́s; Bomfim, Suely Regina Mogami; Silva, Cleverson Oliveira e; Dezan, Elói; Gomes‐Filho, João Eduardo

doi:10.1016/j.joen.2014.01.034

Cited by 37 publications

(73 citation statements)

References 32 publications

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“…The intensity of periapical inflammation was evaluated and classified as previously described by Cintra et al . (,b). The average number of cells per field was considered.…”

Section: Methodsmentioning

confidence: 99%

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Effects of alpha‐lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro‐CT analysis

Aksoy¹,

Savtekin

Şehirli

et al. 2019

Int Endodontic J

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Aim To investigate the possible therapeutic effects of alpha‐lipoic acid (ALA) in a model of chronic apical periodontitis in rats by analysing biochemical, histopathological and micro‐CT parameters. Methodology The study was approved by the Animal Ethics Committee of the Near East University. Thirty‐two Wistar rats were divided into four groups of eight rats each: Control Group; ALA Group; AP Group; AP + ALA Group. In the AP and AP + ALA groups, the pulp chambers of the mandibular first molars were surgically exposed and were left open to the oral environment for 4‐weeks to allow the establishment of periapical lesions. The rats in the Control and AP groups were treated intraperitoneally with saline solution (with a daily dose of 100 mg kg−1, for 28 days after periapical lesion induction). The rats in the ALA and AP + ALA groups were treated intraperitoneally with ALA (with a daily dose of 100 mg kg−1, for 28 days after periapical lesion induction). After decapitation, the trunk blood was collected for the assessment of biochemical parameters. The mandibles were surgically removed and dissected for histopathologic analysis and further scanned with micro‐CT. Groups of data were compared with a two‐way analysis of variance (two‐way anova) followed by Sidak's multiple comparison tests. Values of P < 0.05 were regarded as significant. Results TNF‐α, IL‐1β, MMP‐1, MMP‐2 levels were significantly lower in AP + ALA group compared with AP group (P < 0.05). There was a significant difference between the AP and AP + ALA groups according to assessment of the inflammatory scores (P < 0.05). The periapical inflammatory infiltrates were significantly more severe (P < 0.05) in the AP group. The AP + ALA group exhibited lower values both in terms of surface area and volume of resorption cavities than the AP group and this difference was significant (P < 0.05). Conclusion alpha‐lipoic acid treatment provided therapeutic effects on the inhibition of periapical bone loss.

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“…The intensity of periapical inflammation was evaluated and classified as previously described by Cintra et al . (,b). The average number of cells per field was considered.…”

Section: Methodsmentioning

confidence: 99%

“…, Cintra et al . ,b). The effects of ALA on chronic apical periodontitis originating from the root canal have not been studied.…”

Section: Introductionmentioning

confidence: 99%

Effects of alpha‐lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro‐CT analysis

Aksoy¹,

Savtekin

Şehirli

et al. 2019

Int Endodontic J

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“…This theory was rejected because of the lack of scientific evidence (3). However, results of several recent studies on this topic indicate that dental infections such as apical periodontitis (AP) may potentiate the pathogenesis of autoimmune diseases, mainly by increasing inflammatory cell infiltration and serum cytokine levels (4)(5)(6)(7)(8).…”

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confidence: 99%

Multiple Apical Periodontitis Influences Serum Levels of Cytokines and Nitric Oxide

Cintra

Samuel

Azuma

et al. 2016

Journal of Endodontics

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“…). In the more recent report (Cintra & da Silva Facundo ), the authors investigated the relationship between blood profile and histologic findings in both AP and PD associated with diabetes in Wistar rats. They concluded that diabetes accelerated the development and progression of AP and PD and caused an increase in average erythrocyte volume as well as leucocyte and neutrophil counts.…”

Section: Association Between Endodontics and Diabetes Mellitusmentioning

confidence: 99%

“…Interleukin-17 (IL-17) is a proinflammatory cytokine that mediates multiple chronic inflammatory responses, including angiogenesis, recruitment of inflammatory cells, and induction of proinflammatory mediators by endothelial and epithelial tissues (Ouyang et al 2008, Queiroz-Junior et al 2010). In the more recent report (Cintra & da Silva Facundo 2014c), the authors investigated the relationship between blood profile and histologic findings in both AP and PD associated with diabetes in Wistar rats. They concluded that diabetes accelerated the development and progression of AP and PD and caused an increase in average erythrocyte volume as well as leucocyte and neutrophil counts.…”

Section: Diabetes Mellitus and Apical Periodontitis: Animal Studiesmentioning

confidence: 99%

Endodontic medicine: connections between apical periodontitis and systemic diseases

2015

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The prevalence of apical periodontitis (AP) in Europe has been reported to affect 61% of individuals and 14% of teeth, and increase with age. Likewise, the prevalence of root canal treatment (RCT) in Europe is estimated to be around 30-50% of individuals and 2-9% of teeth with radiographic evidence of chronic persistent AP in 30-65% of root filled teeth (RFT). AP is not only a local phenomenon and for some time the medical and dental scientific community have analysed the possible connection between apical periodontits and systemic health. Endodontic medicine has developed, with increasing numbers of reports describing the association between periapical inflammation and systemic diseases. The results of studies carried out both in animal models and humans are not conclusive, but suggest an association between endodontic variables, that is AP and RCT, and diabetes mellitus (DM), tobacco smoking, coronary heart disease and other systemic diseases. Several studies have reported a higher prevalence of periapical lesions, delayed periapical repair, greater size of osteolityc lesions, greater likelihood of asymptomatic infections and poorer prognosis for RFT in diabetic patients. On the other hand, recent studies have found that a poorer periapical status correlates with higher HbA1c levels and poor glycaemic control in type 2 diabetic patients. However, there is no scientific evidence supporting a causal effect of periapical inflammation on diabetes metabolic control. The possible association between smoking habits and endodontic infection has also been investigated, with controversial results. The aim of this paper was to review the literature on the association between endodontic variables and systemic health (especially DM and smoking habits).

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Blood Profile and Histology in Oral Infections Associated with Diabetes

Cited by 37 publications

References 32 publications

Effects of alpha‐lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro‐CT analysis

Effects of alpha‐lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro‐CT analysis

Multiple Apical Periodontitis Influences Serum Levels of Cytokines and Nitric Oxide

Endodontic medicine: connections between apical periodontitis and systemic diseases

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