Blood purification of bilirubin and bile acids by plasma exchange for patients with liver failure.

Matsubara, Seishiro; Okabe, Kazuto; Ouchi, Kiyoaki; Owada, Yasuo

doi:10.1620/tjem.150.83

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…While MARS can effectively eliminate free bilirubin molecules and bilirubin bound to albumin by noncovalent bonds, it fails to remove δ bilirubin (15). Bilirubin removal dynamics is further complicated by the slow equilibration of bilirubin between the intravascular and extravascular pool (16). Tissue bilirubin is constantly released into the intravascular pool to attain a new equilibrium.…”

Section: Discussionmentioning

confidence: 99%

Molecular adsorbent recirculating system treatment for patients with liver failure: the Hong Kong experience

Chiu

Chan

Fan

2006

Liver International

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Our results indicated that MARS can effectively improve serum biochemistry and is suitable for temporarily supporting patients with liver failure where transplantation is not immediately available. There is, however, no clear evidence showing that MARS can increase survival, improve the chance of transplantation or assist liver regeneration. Future studies in the form of randomized-controlled trials are crucial to characterize the true potential of this treatment.

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Section: Discussionmentioning

confidence: 99%

Molecular adsorbent recirculating system treatment for patients with liver failure: the Hong Kong experience

Chiu

Chan

Fan

2006

Liver International

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“…Therapy based around the Evaclio EC-2C (eg haemodiafiltration) has been described in small series in the Japanese literature [10][11][12][13][14] but this is the first application of HFAF to our knowledge in Europe. The rationale for its use and performance is similar to the Sepet TM system which received United States Food and Drug Administration (FDA) approval for phase 3 evaluation in encephalopathic liver failure, prior to Arbios filing for Chapter 11 bankruptcy protection.…”

Section: Discussionmentioning

confidence: 99%

The Use of High-Flux Albumin Haemofiltration (HFAF) with Evaclio EC-2C™ in the Management of Liver Failure as a Bridge to Transplantation

Morris

Rogerson

2011

Journal of the Intensive Care Society

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Efficacy of liver assisting in patients with hepatic encephalopathy with special focus on plasma exchange

2013

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Severe liver injury result in development of hepatic encephalopathy (HE) and often also in brain edema that is a potentially fatal complication. HE and brain edema are correlated to the level and persistence of hyperammonemia and the presence of systemic inflammation. Treatment of HE and brain edema is based on restoring and keeping normal physiological variables including tonicity, blood gasses, lactate, temperature and vascular resistance by a wide variety of interventions. In addition liver support devices improve the stage of HE, cerebral metabolic rate for oxygen and glucose, and are used either as a bridge to liver transplantation or liver recovery in patients with fulminant hepatic failure and in patients with acute-on-chronic liver failure. This short review will mainly focus on the management and efficacy of doing plasma exchange on HE in patients with acute HE.

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Blood purification of bilirubin and bile acids by plasma exchange for patients with liver failure.

Cited by 6 publications

References 5 publications

Molecular adsorbent recirculating system treatment for patients with liver failure: the Hong Kong experience

Molecular adsorbent recirculating system treatment for patients with liver failure: the Hong Kong experience

The Use of High-Flux Albumin Haemofiltration (HFAF) with Evaclio EC-2C™ in the Management of Liver Failure as a Bridge to Transplantation

Efficacy of liver assisting in patients with hepatic encephalopathy with special focus on plasma exchange

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