Blood Safety in the Developing World and WHO Initiatives

Dhingra, Neelam

doi:10.1111/j.1423-0410.2002.tb05295.x

Cited by 41 publications

(31 citation statements)

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“…Blood transfusion has diminished in importance as a risk of HCV transmission in the developing world since the institution of all-volunteer donation and effective screening methods [6]. It is likely that blood products remain a significant reservoir of HCV in developing nations [7]. Sexual, perinatal and workplace transmission are much less common routes of HCV transmission [8].…”

Section: Hcv Transmissionmentioning

confidence: 99%

Management of patients with chronic hepatitis C infection

2006

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Chronic infection with hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality throughout the world. Although reliable figures regarding the global prevalence of HCV infection are wanting, it is likely that HCV prevalence will continue to increase. Injection drug use is the most important source of HCV transmission in the developed world, while unsafe therapeutic injection is an important source of transmission in developing nations. The majority of exposed individuals become chronically infected, of whom 50% develop chronic liver injury. Cirrhosis and hepatocellular carcinoma can arise in those chronically infected over a mean of 20-30 years. Despite this high prevalence and morbidity, recommendations regarding who to screen by antibody testing remain disparate. Quantitative measurement of HCV RNA and HCV genotyping is useful in predicting response to antiviral therapy. Noninvasive methods of detecting liver injury, such as serologic batteries, have not been as informative or predictable as liver biopsy. The current pharmacologic standard of care for chronic HCV infection is the combination of subcutaneous peginterferon and oral ribavirin, which yields sustained virologic response in 54%-56%. Higher rates of SVR are seen in those patients who are infected with HCV genotypes 2 and 3. As intravenous drug use remains the most important source of HCV transmission in the US and Europe, education within this group is an important preventive tool.

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Section: Hcv Transmissionmentioning

confidence: 99%

Management of patients with chronic hepatitis C infection

2006

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“…It is unlikely that such gains in HCW awareness or perceptions towards the haemovigilance system could have been realised in Namibia without the accompanying comprehensive training programme. To facilitate improvement in the recognition of ATR, blood services, medical and nursing schools and in-service training providers in resource-limited settings should consider adopting elements from existing haemovigilance and transfusion training programmes (Dhingra, 2002; Courbil et al ., 2007). These include providing access to distance learning materials, implementation of self-directed learning tools as part of training, post-training assessments and auditing of blood transfusion practices in hospitals.…”

mentioning

confidence: 99%

Knowledge and barriers related to reporting of acute transfusion reactions among healthcare workers in Namibia

Basavaraju

Lohrke²,

Pitman³

et al. 2013

Transfusion Medicine

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“…The main concern is related to the risk of transfusion transmissible diseases due to unsafe transfusions. This results from blood collection from unsafe donors, the lack of quality system in blood transfusion services, poor laboratory procedures in blood group serology and inadequate testing of donated blood for transfusion transmitted infections (TTI), errors in the administration of blood and a lack of access and appropriate clinical use of blood and blood products for patients requiring transfusion[3]…”

mentioning

confidence: 99%