Blood Serotonin Levels and Male Infertility

Gonzales, Gustavo F.; García-Hjarles, Marco Antonio; Napuri, R; Coyotupa, Juan; Guerra-García, Roger

doi:10.3109/01485018908986755

Cited by 16 publications

(14 citation statements)

References 16 publications

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“…These differences in reproductive outcome for males differing in CSF 5-HIAA could not be explained by variability in sperm quantity or quality. Whereas previous studies found a relationship between sperm motility and density and urinary 5-HIAA and blood serotonin [Segal et al, 1975;Caldamone et al, 1980;Gonzales et al, 1989Gonzales et al, , 1992, we did not find evidence of an association between CSF 5-HIAA and either sperm measure. As the bulk of urinary 5-HIAA is peripheral in origin, and CSF 5-HIAA reflects a CNS measure, differences between the previous studies showing serotonin influences on sperm qualities and the current study may be a result of where the serotonin metabolites were sampled from, with peripheral serotonin more involved in sperm regulation than CNS serotonin functioning.…”

Section: Discussioncontrasting

confidence: 56%

“…Specifically, an early study showed that oligospermic and azoospermic men were more likely to exhibit high concentrations of urinary 5-HIAA [Segal et al, 1975]. Another investigation found that men with abnormally high blood serotonin levels produced lower sperm counts and sperm motility [Gonzales et al, 1989[Gonzales et al, , 1992. Even more compelling evidence connecting serotonergic function with semen quality comes from experiments in which dogs induced with a varicocele, a testicular disorder linked with infertility, produced sperm with less motility and higher blood plasma serotonin levels following alteration [Caldamone et al, 1980].…”

Section: Introductionmentioning

confidence: 99%

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Variation in Reproductive Outcomes for Captive Male Rhesus Macaques <i>(Macaca mulatta)</i> Differing in CSF 5-Hydroxyindoleacetic Acid Concentrations

Gerald

Higley

Lussier³

et al. 2002

Brain Behav Evol

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In rhesus macaque males, lower than average cerebrospinal fluid (CSF) concentrations of the principle metabolite of serotonin, 5-hydroxyindoleacetic acid (5-HIAA), have been linked to impulsivity, involvement in escalated aggression, failure to elicit consort relationships, production of fewer sperm plugs, and a relatively early age of mortality. Given these potential fitness costs, we performed two studies aimed at elucidating the effects of CSF 5-HIAA on reproduction. Study 1 retrospectively evaluated over a four-year period, the relative reproductive outcome for pairs of adult male rhesus macaques (n = 15) who lived in social groups and who differed in concentrations of CSF 5-HIAA. Study 2 examined the relationship between CSF 5-HIAA and sperm motility and density (n = 12), as a potential mechanism for maintaining variability in CSF 5-HIAA. For Study 1, an average measure from two CSF 5-HIAA samples was calculated for the two males who were present during the time when conception most likely took place (offspring birth date –165 ± 14 days). Within-pair comparisons of CSF 5-HIAA concentrations between the sire and the non-successful male were drawn for each of the 72 offspring in the study. We found that while sires were typically the male with relatively higher CSF 5-HIAA within the pair, there were no absolute differences in CSF 5-HIAA between males who sired at least one offspring (sires) and those who failed to reproduce (non-sires). Furthermore, while absolute age was not predictive of reproductive outcome, sires with relatively high CSF 5-HIAA also tended to be also relatively older than their competitors. By contrast, for the males with relatively low CSF 5-HIAA who reproduced, sires were relatively younger than the non-sires. These differences in reproductive outcome for males differing in CSF 5-HIAA could not be explained by variability in sperm quantity or quality as we did not find evidence of a relationship between CSF 5-HIAA and either sperm measure. The results of this study suggest that as serotonergic function affects many aspects of behavior and survivorship, it might also be associated with reproductive outcome and different life-history strategies for males differing in concentrations of CSF 5-HIAA.

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Section: Discussioncontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Variation in Reproductive Outcomes for Captive Male Rhesus Macaques <i>(Macaca mulatta)</i> Differing in CSF 5-Hydroxyindoleacetic Acid Concentrations

Gerald

Higley

Lussier³

et al. 2002

Brain Behav Evol

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“…A subject was considered asthenozoospermic if the semen sample had < 60% motile sperm or < 30% sperm with excellent motility. As the prevalence of asthenozoospermia obtained after evaluation of the sperm motility at 2 h is almost the same as that obtained after 4 h (Gonzales, 1985), and as subjects who have normal motility at 2 h maintain this at 4 h (Bilgeri et al, 1987;Mandal & Bhattacharyya, 1987) we have used values at 4 h to correlate sperm motility with corrected values of seminal fructose assayed at the same time.…”

Section: Semen Analysismentioning

confidence: 97%

The secretory activity of the seminal vesicles and its relationship to sperm motility: effects of infection in the male reproductive tract

et al. 1989

Self Cite

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In 146 males aged between 20 years and 40 years attending an infertility service, the secretory activity of the seminal vesicles was assessed by measurement of corrected seminal fructose concentration. This value was related to the presence of a positive semen culture, other evidence of inflammatory processes in the reproductive tract and sperm motility. Only 48% of subjects with a positive semen culture showed evidence of inflammation in the reproductive tract, as assessed by the presence of more than 20 white blood cells per high power field, and greater than 10% spermagglutination in the ejaculate. There was a relationship between the inflammatory process, hypofunction of the seminal vesicles and poor sperm motility. When the semen culture was positive but there was no evidence of inflammation neither seminal vesicle function nor sperm motility was affected. When the semen culture was negative, i.e. no evidence of inflammation and the subjects were asthenozoospermic, the corrected fructose levels were normal. It is proposed that in these conditions the cause of asthenozoospermia may be factors other than accessory sex organ dysfunction. In conclusion, there was no close relationship between the bacteriological results and evidence of inflammation of the accessory glands. A positive semen culture was related to lower levels of corrected fructose (hypofunction of the seminal vesicles) when the positive sperm culture was associated with inflammation of the reproductive tract and asthenozoospermia.

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“…Daily injections of 5-HT precursor (5-hydroxytryptophan (5-HTP)) alter reproductive development and age-dependent body weight gain in mice, accompanied by a low testosterone level and highly reduced sperm counts, motility, and viability (Sethi & Chaturvedi 2009). In addition, studies in humans reported that hyperserotonemia derives in azoospermia (Gonzales et al 1989(Gonzales et al , 1992. Furthermore, in reproductive pathologies such as varicocele, 5-HT blood levels are elevated and it has also been proven that serotoninergic neurotransmission dysfunctions are involved in premature ejaculation (de Jong et al 2006, Chan et al 2008, Motofei 2008.…”

Section: Introductionmentioning

confidence: 99%

Evidence of 5-HT components in human sperm: implications for protein tyrosine phosphorylation and the physiology of motility

Jiménez-Trejo¹,

Tapia-Rodríguez²,

Cerbón³

et al. 2012

Reproduction

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Serotonin (5-hydroxytryptamine; C 10 H 12 N 2 O (5-HT)) is produced in the CNS and in some cells of peripheral tissues. In the mammalian male reproductive system, both 5-HT and tryptophan hydroxylase (TPH) have been described in Leydig cells of the testis and in principal cells of the caput epididymis. In capacitated hamster sperm, it has been shown that 5-HT promotes the acrosomal reaction. The aim of this work was to explore the existence of components of the serotoninergic system and their relevance in human sperm physiology. We used both immunocytochemistry and western blot to detect serotoninergic markers such as 5-HT, TPH1, MAO A , 5-HT 1B , 5-HT 3 , and 5HT T ; HPLC for TPH enzymatic activity; Computer Assisted Semen Analysis assays to measure sperm motility parameters and pharmacological approaches to show the effect of 5-HT in sperm motility and tyrosine phosphorylation was assessed by western blot. We found the presence of serotoninergic markers (5-HT, TPH1, MAO A , 5-HT 1B , 5-HT 2A , 5-HT 3 , 5-HT T , and TPH enzymatic activity) in human sperm. In addition, we observed a significant increase in tyrosine phosphorylation and changes in sperm motility after 5-HT treatment. In conclusion, our data demonstrate the existence of components of a serotoninergic system in human sperm and support the notion for a functional role of 5-HT in mammalian sperm physiology, which can be modulated pharmacologically.

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Blood Serotonin Levels and Male Infertility

Cited by 16 publications

References 16 publications

Variation in Reproductive Outcomes for Captive Male Rhesus Macaques <i>(Macaca mulatta)</i> Differing in CSF 5-Hydroxyindoleacetic Acid Concentrations

Variation in Reproductive Outcomes for Captive Male Rhesus Macaques <i>(Macaca mulatta)</i> Differing in CSF 5-Hydroxyindoleacetic Acid Concentrations

The secretory activity of the seminal vesicles and its relationship to sperm motility: effects of infection in the male reproductive tract

Evidence of 5-HT components in human sperm: implications for protein tyrosine phosphorylation and the physiology of motility

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