Blood Serum Characteristics of Newborn Pigs: Comparison of Unaffected Pigs with Pigs Belonging to Five Mortality Groups

Svendsen, L. S.; Weström, Björn; Svendsen, J.; Olsson, Anne-Charlotte; Karlsson, Börje W.

doi:10.1186/bf03546957

Cited by 21 publications

(8 citation statements)

References 18 publications

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“…Hypoxia during prolonged births or birth in the last third of a litter leads to an increase of lactate (38, 39). Higher haemoglobin levels at birth make piglets less prone to hypoxia due to the higher oxygen binding capacity (40). No association to survival was seen for both variables in this study.…”

Section: Discussioncontrasting

confidence: 66%

Killing Underweighted Low Viable New-Born Piglets – A First Step to a Reliable and Comprehensive Decision

Geiping

Hartmann

Kreienbrock

et al. 2021

Preprint

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Background The aim of this study was to estimate the mortality risk within the first days of life for underweight or low-vital neonatal piglets. This risk estimation should start a discussion concerning the pre-conditions for the killing of compromised new-born piglets for the prevention of unnecessary pain and suffering. In a field study, various clinical and laboratory variables were examined in 529 piglets out of four farms. Body weight, crown-rump-length, rectal temperature, a 4-stage vitality score, an intrauterine-growth-retardation score, glucose, lactate, haemoglobin and immunocrit were assessed on the first day of life. Vitality was scored by three factors: movement, abdominal palpation and colour of the skin. Afterwards death or survival of the piglets was monitored up until the fifth day of age. Results Body weight, crown-rump-length, rectal temperature, vitality score, IUGR-score, glucose and immunocrit were significantly associated with the probability of death (univariate model, p = < 0.0001). The final predictive multivariate model comprised the factors body weight, rectal temperature and vitality score. Piglets with a rectal temperature ≤ 37.5°C and moderate vitality score were found to have the highest probability to die until day 5 of age. Conclusion The clinical findings, identified by this model, allow the estimation of mortality risk for a new-born piglet within the first days of life. In a further analysis veterinarians, farmers and ethics need to clarify which probability of death justifies the killing of a new-born piglet.

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Section: Discussioncontrasting

confidence: 66%

Killing Underweighted Low Viable New-Born Piglets – A First Step to a Reliable and Comprehensive Decision

Geiping

Hartmann

Kreienbrock

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Measurements of other enzymes (e.g., Ca 2+ -ATPase in nervous system, catalase as key enzyme of peroxide depletion) as well as of metabolites and serum proteins (glucose, α2-macroglobulins, and ascorbic acid) sometimes revealed significant differences between PCS and control groups. However, the results could not be convincingly related to a pathogenic mechanism for the syndrome (45)(46)(47). Changes in K + -distribution are also in line with a supposed loss of cellular membrane integrity (42).…”

Section: Biochemical Characteristicsmentioning

confidence: 87%

Congenital Splay Leg Syndrome in Piglets—Current Knowledge and a New Approach to Etiology

2021

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The porcine congenital splay leg syndrome (PCS), even though being of transient nature, is still one of the most important causes for piglet losses due to its high incidence and mortality. Although, described decades ago, the pathogenetic mechanism is still elusive. Numerous, mostly descriptive studies characterized the syndrome at clinical, histological and cellular levels but resulted in a highly diverse picture of the syndrome. Broad variability in phenotypical expression and, in case of proper care, the rapid recovery of affected animals complicated a systematical analysis of the underlying pathogenesis. Although, several environmental factors were discussed as potential causes of PCS, most of the evidence points to a hereditary basis of PCS. Nevertheless, only few of the suggested candidate genes from transcriptome and mapping analyses, like F-box protein 32 (FBXO32), could be confirmed so far. Only recently, a genome wide association study revealed genomic regions on five porcine chromosomes and named a number of potential candidate genes, among them homer scaffold protein 1 (HOMER1). This new candidate—a cellular scaffold protein—plays a role in a plethora of cellular signaling cascades, and is not only involved in skeletal muscle differentiation but also critical for muscular function. In this review, we critically elucidate the current state of knowledge in the field and evaluate current achievements in the identification of the pathogenetic mechanism for the syndrome.

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“…Hypoxia during prolonged births or birth in the last third of parturition leads to an increase of lactate [ 40 , 41 ]. Higher haemoglobin levels at birth make piglets less prone to hypoxia due to the higher oxygen carrying capacity [ 42 ]. No association to survival was seen for both variables in this study.…”

Section: Discussionmentioning

confidence: 99%

Killing underweighted low viable newborn piglets: Which health parameters are appropriate to make a decision?

et al. 2022

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Background The aim of this study was to estimate the mortality risk and associated factors within the first days of life for underweight or low-vital neonatal piglets. This risk estimation should start a discussion concerning the preconditions for timely killing of compromised newborn piglets to prevent unnecessary pain and suffering. In an observational study, various clinical and laboratory variables were examined in 529 piglets out of four farms. Body weight, crown-rump-length, rectal temperature, a 4-stage vitality score, an intrauterine-growth-retardation score, glucose, lactate, haemoglobin and immunocrit were assessed on the first day of life. Vitality was scored by three factors: movement, abdominal palpation, and colour of the skin. Afterwards the death of the piglets (by killing or spontaneously) was monitored until day 5 of age. Results Body weight, rectal temperature and vitality score were significantly associated with probability of death. Piglets with rectal temperatures ≤ 37.5 °C, a body weight < 0.86 kg and impaired vitality scores were found to have the highest probability of death until day 5 of age. Conclusion The clinical findings, identified by this model, allow a first estimation of mortality risk for newborn piglets within the first days of life. In a further step veterinarians, farmers and ethicians now need to clarify what probability of death should justifiy the killing of a newborn piglet.

show abstract

Blood Serum Characteristics of Newborn Pigs: Comparison of Unaffected Pigs with Pigs Belonging to Five Mortality Groups

Cited by 21 publications

References 18 publications

Killing Underweighted Low Viable New-Born Piglets – A First Step to a Reliable and Comprehensive Decision

Killing Underweighted Low Viable New-Born Piglets – A First Step to a Reliable and Comprehensive Decision

Congenital Splay Leg Syndrome in Piglets—Current Knowledge and a New Approach to Etiology

Killing underweighted low viable newborn piglets: Which health parameters are appropriate to make a decision?

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