Blood-Stage Immunity to Malaria

Stanisic, Danielle I.; Good, Michael F.

doi:10.1007/978-1-4614-8757-9_132-1

Cited by 1 publication

(1 citation statement)

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“…In malarial, large numbers of antigens are expressed in each stage of the parasite life cycle including the short asymptomatic liver stage (exoerythrocytic) and the symptomatic blood stage (erythrocytic stage) (Kalkal et al, 2022a ). At the blood stage of infection, clinical symptoms of malarial start to appear after a silent liver stage and effective anti-parasitic immunity starts at this stage of infection involving multiple immune cells (Stanisic and Good, 2019 ). Humoral/antibody or B-cell response represents a critical component of the protective immune response at the blood-stage infection of malarial disease.…”

Section: Immunological Role Of B Cells In Malarial Pathogenesismentioning

confidence: 99%

Current understanding of the immune potential of B-cell subsets in malarial pathogenesis

Kalkal

Das

2023

Front. Microbiol.

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In the past several decades, our understanding of how B cells are generated and what function they perform has continued to advance. It is widely accepted that B-cell subsets play a critical role in mediating immune response. Surprisingly, human and murine malarial infections cause major alterations in the composition of B-cell subsets in both the spleen and periphery. Multiple B-cell subsets are well characterized in murine models following primary and secondary infection, although in human malarial infection, these subsets are not well defined. Furthermore, a rare known function of B cells includes the potential role of regulating the activities of other cells in the body as regulatory cells. Plasmodium infection strongly alters the frequency of these regulatory B cells indicating the immunoregulatory function of B cells in malarial. It is important to note that these subsets, taken together, form the cellular basis of humoral immune responses, allowing protection against a wide array of Plasmodium antigens to be achieved. However, it remains a challenge and an important area of investigation to understand how these B-cell subsets work together to provide protection against Plasmodium infection.

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Section: Immunological Role Of B Cells In Malarial Pathogenesismentioning

confidence: 99%