Blood Stream Infection in Pediatric Patients of a Tertiary Care Hospital:  A Bacteriological and Antimicrobial Profile

Sangeetha, A. Ramya S.; Prakash, S.A. Lakshminarayana R.

doi:10.20546/ijcmas.2017.603.164

Cited by 3 publications

(4 citation statements)

References 3 publications

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“…Previous studies reported the prevalence of ESBL K. pneumonia was 78.3%, whereas low prevalences have been reported for ESBL E. coli (30% and 11.2% respectively) [1,21] In this study, other Gram-negative bacteria such as P. aeruginosa and Enterobacter spp showed the same patterns of resistance as in previous studies. [16,18] The current study also showed that MRSA strains had high susceptibility to vancomycin, linezolid, chloramphenicol, and rifampicin, whereas they showed highest resistance against augmentin, ampicillin, cefepime, and cefoxitin. This result was consistent with the previous reports.…”

Section: Discussionsupporting

confidence: 57%

“…In our study predominant organism were S. typhi and S. paratyphi, and <32% resistance has been observed to all the tested antibiotics except ciprofloxacin (77%), which is in accordance with the report from India. [18] We found that E. coli was highly resistant to ciprofloxacin, aztreonam, co-triamoxazole, ceftriaxone and ceftazidime. There are multiple risk factors involved in the resistance of E. coli against antibiotics, such as recent administration of antibiotics, prophylactic therapy for urinary tract infection, and hospitalization.…”

Section: Discussionmentioning

confidence: 80%

“…Of the total blood culture samples, 19.6% (n=111) showed bacterial growth, which was in accordance with the reports from Iran, whereas relatively low frequency of positive cases were reported in others studies. [15][16][17][18] The low pathogens yield in other studies were possibly due to the low quantity of blood inoculation in culture media, variation in bacteriological techniques, and prior use of antimicrobials for the management of BSI. [19][20][21] The present study found that a wide range of bacterial pathogens were involved in BSI.…”

Section: Discussionmentioning

confidence: 99%

“…[3] However, high percentages of MRSA was reported in the studies from Pakistan and India. [15,18] Majority of the bacteria such as E. coli and K. pneumonia acquire drug resistance mainly due to beta-lactam enzymes encoded on plasmid and chromosome. [26] In conclusion, we identified S. typhi, E. coli, S.…”

Section: Discussionmentioning

confidence: 99%

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Bacterial Spectrum and Antimicrobial Profile of Pediatric Blood Stream Infection at a Tertiary Care Hospital in Pakistan

Muhammad

Khan

Jamal³

et al. 2020

Chinese Medical Sciences Journal

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Bacterial Spectrum and Antimicrobial Profile of Pediatric Blood Stream Infection at a Tertiary Care Hospital in Pakistan

Muhammad

Khan

Jamal³

et al. 2020

Chinese Medical Sciences Journal

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Phenotypic Bacterial Isolates, Antimicrobial Susceptibility pattern and Associated factors among Septicemia Suspected Patients at a hospital, in Northwest Ethiopia: Prospective cross-sectional study

Belew

Tamir

Dilnessa

et al. 2023

Ann Clin Microbiol Antimicrob

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Background Septicemia is potentially fatal infection caused by pathogenic bacteria infiltrating the bloodstream, resulting in morbidity and mortality among Ethiopian hospital patients. Multidrug resistance is a therapeutic challenge in this patient population. There is an insufficiency data among hospitals in Ethiopia. Hence, this study aimed to assess the phenotypic bacterial isolates, antimicrobial susceptibility pattern, and associated factors among septicemia suspected patients. Methods Prospective cross-sectional study was conducted among 214 septicemia suspected patients from February to June 2021 at Debre Markos Comprehensive Specialized hospital in northwest, Ethiopia. Blood samples were collected aseptically and processed to identify bacterial isolates by using different standard microbiological procedures. Antimicrobial susceptibility pattern was performed using the modified Kirby Bauer disc diffusion on Mueller Hinton agar. Epi-data V4.2 was used to enter data and SPSS V25 for analysis. The variables were assessed using a bivariate logistic regression model with a 95% confidence interval, and declared statistically significant; P-value was < 0.05. Results The overall bacterial isolates was found 45/214 (21%) in this study. Gram-negative and positive bacteria were 25/45(55.6%), 20/45(44.4%) respectively. The most common bacterial isolates were Staphylococcus aureus12/45 (26.7%), Klebsiella pneumoniae 8/45(17.8%), Escherichia coli 6/45 (13.3%). Gram-negative bacteria showed susceptibility to amikacin (88%), meropenem, imipenem (76%) but, (92%) resistance to ampicillin, (85.7%) amoxicillin-clavulanic acid. S.aureus (91.7%) was resistance to Penicillin, (58.3%) cefoxitin and (75%) susceptible to ciprofloxacillin. S.pyogenes and S.agalactia were (100%) susceptible to Vancomacin. Multidrug resistance was found in 27/45(60%) of the bacterial isolates. The main predictors related to patients suspected of septicemia were prolonged hospitalization (AOR = 2.29, 95% CI: 1.18, 7.22), fever (AOR = 0.39, 95%CI: 0.18, 0.85) and length of hospital stay (AOR = 0.13, 95%CI: 0.02, 0.82). Conclusions Incidence of bacterial isolates among septicemia suspected patients were high. The majority of the bacterial isolates were multidrug-resistant. To prevent antimicrobial resistance, specific antibiotic utilization strategy should be applied.

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The predictors of outcome and progression of pediatric sepsis and septic shock

Shah¹,

Deshmukh²,

Tullu³

2020

Journal of Postgraduate Medicine

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Introduction: There is a paucity of studies on the progression and outcome of Systemic Inflammatory Response Syndrome (SIRS) with its determinants. Aims and Objectives: To determine the predictors of the outcome and progression of pediatric sepsis and septic shock. Materials and Methods: Prospective observational study of children fulfilling criteria of SIRS and their progression to sepsis, severe sepsis, and septic shock (clinically and biochemically) was conducted at a tertiary care center. Results: Totally, 200 children were recruited over a period of 21 months (from February 2016 to October 2017). Most cases (80, 40%) were infants. Of the total, 188 (94%) cases were of an infective etiology (mostly respiratory system). Temperature and heart rate were the two commonest SIRS parameters which were deranged. Blood cultures were positive in only 25 (12.5%) cases. Out of the total 200 children, 108 progressed to sepsis, of which 26 progressed to severe sepsis, of which 22 progressed to septic shock. Abnormal leukocyte count, culture positivity and severe acute malnutrition were significantly associated with progression of SIRS patients to septic shock (P = 0.001, 0.00001 and 0.002, respectively). Factors associated with mortality were positive blood culture, multiorgan dysfunction, late hospital admissions, severe acute malnutrition, and requirement of supportive care (P values-<0.0001, <0.0001, 0.03, <0.0001 and <0.0001, respectively). Conclusions: SIRS can progress to septic shock if not identified early. The predictors of mortality were positive blood cultures, multiorgan dysfunction, late hospital admissions, severe acute malnutrition, and requirement of supportive care. The predictors of progression to septic shock were abnormal leukocyte count, culture positivity, and severe acute malnutrition.

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Blood Stream Infection in Pediatric Patients of a Tertiary Care Hospital: A Bacteriological and Antimicrobial Profile

Cited by 3 publications

References 3 publications

Bacterial Spectrum and Antimicrobial Profile of Pediatric Blood Stream Infection at a Tertiary Care Hospital in Pakistan

Bacterial Spectrum and Antimicrobial Profile of Pediatric Blood Stream Infection at a Tertiary Care Hospital in Pakistan

Phenotypic Bacterial Isolates, Antimicrobial Susceptibility pattern and Associated factors among Septicemia Suspected Patients at a hospital, in Northwest Ethiopia: Prospective cross-sectional study

The predictors of outcome and progression of pediatric sepsis and septic shock

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