Blood stream infections due to multidrug-resistant organisms among spinal cord-injured patients, epidemiology over 16 years and associated risks: a comparative study

Abstract

During BSI occurrence in an SCI population, MDROs are frequent but remain stable over years. No associated risk can be identified that would help optimize antibiotic treatment. Neither the severity of the episode nor the mortality is significantly different when an MDRO is involved.

Gut dysbiosis impairs recovery after spinal cord injury

“…Because antibiotics are used to treat bacteremia in SCI patients (Waites et al, 2001; Evans et al, 2009; Dinh et al, 2016), it was important to determine whether antibiotics and the subsequent onset of dysbiosis can cause delayed neurological impairment. To test this, mice received an SCI, and, 2 wk later after locomotor function plateaued, antibiotics were added to the drinking water of half the mice.…”

Ceftolozane/tazobactam for febrile UTI due to multidrug-resistant Pseudomonas aeruginosa in a patient with neurogenic bladder

“…of MDR organisms in a specific population already overexposed to antimicrobials with a high rate of MDR carriers. 3,9 Therefore, we report the first case of severe pyelonephritis due to MDR PSA in a SCI patient with neurogenic bladder and foreign device successfully treated with short-course C/T monotherapy. These results should be confirmed by controlled studies, ideally a randomized double-blinded control trial.…”

“…Their management remains a clinical challenge especially among patients with neurogenic bladder. [9][10][11][12] Moreover, the indication of dual therapy for infections due to PSA is still under debate. Combination therapy with two antipseudomonal agents is often empirically started to avoid initial inappropriate empirical antibiotic therapy, which is an independent risk factor for mortality.…”

Outcome of bloodstream infections among spinal cord injury patients and impact of multidrug-resistant organisms

“…[2][3][4][5][6][7][8] Colonizing multidrug-resistant organisms (MDROs) are frequent in the SCI population. 7,[9][10][11][12][13] In the general population, hospital-acquired infections and MDRO infections are associated with increased mortality and increased cost. 7 In the SCI population, such infections have been shown to increase the number of hospitalizations and the length of stay.…”

“…Also, it was not significantly different regarding age, gender, type and duration of SCI, primary site of infection or bacteria species involved. 9 From this large cohort, we studied the severity and mortality of BSI according to the primary site of infection and according to the drug resistance characteristics of the microorganisms involved.…”