Blood Stream Infections in Renal Transplant Recipients: A Single-Center Study

Epidemiology and impact of bloodstream infections among kidney transplant recipients: A retrospective single‐center experience

“…This ratio was higher than in other series. In the RESITRA (Spanish network) database, the BSI episodes/patient ratio was 1.2 (121 episodes in 102 patients), and this was quite similar in a Greek experience where 22 RTR presented 26 BSI episodes giving a ratio of 1.18 BSI episode/patient . The growing antibiotic resistance among causative bacteria can be a contributing factor to the higher recurrence rates in our study.…”

“…The prevalence of ESBL‐producing organisms was noted to increase with time among E. coli bloodstream isolates from 0% to 8% between 2000 and 2007 . The trend was higher in later studies, though our study (2009‐2016) showed less frequent ESBL‐producing E. coli (12.7%) and Klebsiella (29.2%) than reported in the Greek experience (2010‐2013): 2/6 (33.3%) for E. coli and 2/5 (40%) for Klebsiella . These findings signify the increasing risk for RTR to develop infection by multidrug‐resistant pathogens …”

“…Interestingly, UTI as a source of BSI did not have significant effect on the incidence of AKI or percent change in kidney function when compared to non‐urinary sources. The rate of AKI varied among previous studies from 28% (6/22 patients); all resolved after infection control, in one study to 50% (20/40) in another with 21.1% incomplete resolution rate . Transplant AKI is known to have potential long‐term consequences with significantly higher rates of transplant loss and death with a functioning graft.…”

“…In the recurrent‐episode group of patients, 30% had >1 BSI episode of urinary origin caused by the same organism and 9.2% of patients had 3 or more episodes (8/87). Thus, prevention and early detection of UTI remain important to reduce the risk of BSI, particularly in patients with prior UTI with or without BSI …”

“…Multiple portals of entry exist for organisms causing BSI, but urinary tract infection (UTI) has been identified as the most common source of BSI among RTR and was responsible for 30%‐72.7% of BSI episodes . Gram‐negative pathogens are responsible for the majority of BSI in RTR accounting for 80.5% in one series, and Escherichia coli was reported to be the most common causative organism …”