Blood trace minerals concentrations and oxidative stress in patients with obstructive sleep apnea

Chen, P. C.; Guo, Chih-Hung; Tseng, Chien-Sen; Wang, K. C.; Liu, Po-Jen

doi:10.1007/s12603-013-0023-x

Cited by 40 publications

(33 citation statements)

References 40 publications

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“…In addition, Mn is an important antioxidant. Cobalt (Co) is a critical fragment of vitamin B 12 that is crucial in foliate and fatty acid metabolism [6] . Lead (Pb) down-regulates nitric oxide production and induces oxidative stress and inflammation.…”

Section: Introductionmentioning

confidence: 99%

Serum Trace Elements and Heavy Metal Levels in Patients Diagnosed with Chronic Otitis Media and Their Association with Surgical Treatment Outcomes

Bozan¹,

Dinç²,

Demır³

et al. 2017

Int Adv Otol

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OBJECTIVE:To determine the serum iron (Fe), zinc (Zn), manganese (Mn), copper (Cu), magnesium (Mg), cobalt (Co), and lead (Pb) levels in patients with chronic otitis media (COM) and to evaluate the association of the serum levels of these elements with treatment outcomes. MATERIALS and METHODS:Thirty-one healthy volunteers and 31 patients with COM were prospectively included in this study. Serum levels of Fe, Zn, Mn, Mg, Cu, Co, and Pb were determined by an atomic absorption UNICAM-929 spectrophotometer.RESULTS: Serum Co, Pb, and Fe levels were significantly increased (p<0.001) and serum Cu, Zn, Mg, and Mn levels were significantly reduced in patients with COM compared with controls (p<0.001). Serum Co and Mn levels were significantly decreased (p<0.001 and p<0.005, respectively) and serum Cu levels were significantly increased after surgery (p<0.005). The other evaluated blood chemicals and heavy metals did not exhibit significant differences (p>0.05). CONCLUSION:Significant alterations in the serum chemical composition of patients with COM were observed. Moreover, with surgical treatment, serum levels of some of these chemicals were significantly altered. Further prospective studies are warranted to elucidate the exact association of these alterations in the etiopathogenesis of COM.

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Section: Introductionmentioning

confidence: 99%

Serum Trace Elements and Heavy Metal Levels in Patients Diagnosed with Chronic Otitis Media and Their Association with Surgical Treatment Outcomes

Bozan¹,

Dinç²,

Demır³

et al. 2017

Int Adv Otol

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show abstract

“…Infusion of selective inhibitors of PGDS, e.g., tetravalent selenium compounds, reversibly, time-and dose-dependently inhibited both nonrapid eye movement (NREM) and rapid eye movement (REM) sleep during the daytime [194], which shows that PGDS plays a crucial role in the regulation of physiological sleep. Selenium deficit may result in severe disorders [195,196], including mood disorders. Gosney et al [197] reported the effects of micronutrient supplementation on mood in nursing home residents; selenium supplementation was directly correlated with decreases in depression scores and increases in serum levels.…”

Section: Seleniummentioning

confidence: 99%

Nutrition, Sleep and Sleep Disorders – Relations of Some Food Constituents and Sleep

Partinen

Westermarck²,

Atroshi³

2014

Pharmacology and Nutritional Intervention in the Treatment of Disease

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The enteric nervous system (ENS) can be considered the body's second brain with more than 100 million neurons of different types. Neural signals may be transmitted from gut to the CNS by neural connection and by humoral mechanisms. The afferent fibers of the gut-brain neural are vagal (parasympathetic) and (ortho)sympathetic. Different sensors respond also to distension of stomach and contractions of the intestine. Chemical stimuli (e.g. spices), gut hormones, neurotransmitters, neuromodulators, cytokines and inflammatory mediators produced by the bacterial flora in the gut-are all important. In the brainstem most afferent vagal fibers terminate on the nucleus tractus solitarius (NTS). There is a viscerotopic representation of different parts of the enteric system in the NTS. The NTS is in connection with hypothalamus and amygdala, which also plays a role in regulation of hunger and satiety. We

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“…Development of these conditions has been attributed to increased levels of intracellular reactive oxygen species (ROS) during reoxygenation coupled [6] with reduced levels of antioxidant enzymes [7, 8]. Cardiac dysfunction in OSA is also attributed to hypoxia-associated increases in inflammation [9, 10]. High circulating levels of proinflammatory cytokines, such as tumour necrosis factor α (TNF-α), interleukin 6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), and vascular cell adhesion molecule 1 (VCAM-1), have been found in OSA patients [11–14].…”

Section: Introductionmentioning

confidence: 99%

“…These results suggest that patients with OSA may benefit from zinc replacement therapy to decrease oxidative stress and reduce inflammation [9, 15]. Although zinc supplementation can provide protective antioxidant and anti-inflammatory effects [16–18], cardiac function will decline with increasing age without the stimulus of exercise [19].…”

Section: Introductionmentioning

confidence: 99%

Zinc Is Indispensable in Exercise-Induced Cardioprotection against Intermittent Hypoxia-Induced Left Ventricular Function Impairment in Rats

Chen

2016

PLoS ONE

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In obstructive sleep apnea (OSA), recurrent obstruction of the upper airway leads to intermittent hypoxia (IH) during sleep, which can result in impairment of cardiac function. Although exercise can have beneficial effects against IH-induced cardiac dysfunction, the mechanism remains unclear. This study aimed to investigate the interactions of zinc and exercise on IH-triggered left ventricular dysfunction in a rat model that mimics IH in OSA patients. Nine-week-old male Sprague-Dawley rats were randomly assigned to either a control group (CON) or to a group receiving 10 weeks of exercise training (EXE). During weeks 9 and 10, half the rats in each group were subjected to IH for 8 h per day for 14 days (IHCON, IHEXE), whereas the remainder continued to breathe room air. Rats within each of the CON, IHCON, EXE, and IHEXE groups were further randomly assigned to receive intraperitoneal injections of either zinc chloride, the zinc chelator N,N,N',N'-tetrakis(2-pyridylmethyl) ethylenediamine (TPEN), or injection vehicle only. IH induced a lower left ventricular fractional shortening, reduced ejection fraction, higher myocardial levels of inflammatory factors, increased levels oxidative stress, and lower levels of antioxidative capacity, all of which were abolished by zinc treatment. IHEXE rats exhibited higher levels of cardiac function and antioxidant capacity and lower levels of inflammatory factors and oxidative stress than IHCON rats; however, IHEXE rats receiving TPEN did not exhibit these better outcomes. In conclusion, zinc is required for protecting against IH-induced LV functional impairment and likely plays a critical role in exercise-induced cardioprotection by exerting a dual antioxidant and anti-inflammatory effect.

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Blood trace minerals concentrations and oxidative stress in patients with obstructive sleep apnea

Abstract: Abnormal concentrations of these trace minerals may reflect oxidative damage and inflammatory response, thus increasing the severity of OSA.

Cited by 40 publications

References 40 publications

Serum Trace Elements and Heavy Metal Levels in Patients Diagnosed with Chronic Otitis Media and Their Association with Surgical Treatment Outcomes

Serum Trace Elements and Heavy Metal Levels in Patients Diagnosed with Chronic Otitis Media and Their Association with Surgical Treatment Outcomes

Nutrition, Sleep and Sleep Disorders – Relations of Some Food Constituents and Sleep

Zinc Is Indispensable in Exercise-Induced Cardioprotection against Intermittent Hypoxia-Induced Left Ventricular Function Impairment in Rats

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