Blood transcriptional profiles distinguish different clinical stages of cutaneous leishmaniasis in humans

Bahrami, Fatemeh; Masoudzadeh, Nasrin; Veen, Sylvia; Persson, Josefine; Lari, Arezou; Sarvnaz, Hamzeh; Taslimi, Yasaman; Östensson, Malin; Andersson, Björn; Sharifi, Iraj; Goyonlo, Vahid Mashayekhi; Ottenhoff, Tom H. M.; Haks, Mariëlle C.; Harandi, Ali M.; Rafati, Sima

doi:10.1016/j.molimm.2022.07.008

Cited by 3 publications

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The utilization of a herbal remedy, containing C. longa as an active component, showcased encouraging outcomes. Among patients afflicted with cutaneous leishmaniasis, the administration of this plant juice combination resulted in a healing rate of around 40%, surpassing the 32.71% curative rate observed with the exclusive use of Meglumine antimonate [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Computational investigation of turmeric phytochemicals targeting PTR1 enzyme of Leishmania species

Ullah,

Wu,

Malak

et al. 2024

Heliyon

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Computational investigation of turmeric phytochemicals targeting PTR1 enzyme of Leishmania species

Ullah,

Wu,

Malak

et al. 2024

Heliyon

View full text Add to dashboard Cite

Cutaneous leishmaniasis: multiomics approaches to unravel the role of immune cells checkpoints

Taslimi

Masoudzadeh

Bahrami

et al. 2022

Expert Review of Proteomics

View full text Add to dashboard Cite

Intralesional gene expression profile of JAK-STAT signaling pathway and associated cytokines in Leishmania tropica-infected patients

Hadifar,

Masoudzadeh,

Heydari

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

BackgroundThe JAK-STAT signaling pathway is a central cascade of signal transduction for the myriad of cytokines in which dysregulation has been implicated in progression of inflammatory and infectious diseases. However, the involvement of this pathway in human cutaneous leishmaniasis (CL) due to Leishmania (L.) tropica warrants further investigation.MethodsThis study sought to investigate differential gene expression of several cytokines and their associated jak-stat genes in the lesions of L. tropica-infected patients byquantitative Real-Time PCR. Further, the expression of five inhibitory immune checkpoint genes was evaluated.ResultsResults showed that the gene expression levelsof both Th1 (ifng, il12, il23) and Th2 (il4, il10) types cytokines were increased in the lesion of studied patients. Further, elevated expression levels of il35, il21, il27 and il24 genes were detected in the lesions of CL patients. Notably, the expression of the majority of genes involved in JAK/STAT signaling pathway as well as checkpoint genes including pdl1, ctla4 and their corresponding receptors was increased.ConclusionOur finding revealed dysregulation of cytokines and related jak-stat genes in the lesion of CL patients. These results highlight the need for further exploration of the functional importance of these genes in the pathogenesis of, and immunity to, CL.

show abstract

Blood transcriptional profiles distinguish different clinical stages of cutaneous leishmaniasis in humans

Cited by 3 publications

References 33 publications

Computational investigation of turmeric phytochemicals targeting PTR1 enzyme of Leishmania species

Computational investigation of turmeric phytochemicals targeting PTR1 enzyme of Leishmania species

Cutaneous leishmaniasis: multiomics approaches to unravel the role of immune cells checkpoints

Intralesional gene expression profile of JAK-STAT signaling pathway and associated cytokines in Leishmania tropica-infected patients

Contact Info

Product

Resources

About