2023
DOI: 10.1038/s41467-023-39652-6
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Blood transcriptomic signatures associated with molecular changes in the brain and clinical outcomes in Parkinson’s disease

Abstract: The ability to use blood to predict the outcomes of Parkinson’s disease, including disease progression and cognitive and motor complications, would be of significant clinical value. We undertook bulk RNA sequencing from the caudate and putamen of postmortem Parkinson’s disease (n = 35) and control (n = 40) striatum, and compared molecular profiles with clinical features and bulk RNA sequencing data obtained from antemortem peripheral blood. Cognitive and motor complications of Parkinson’s disease were associat… Show more

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Cited by 16 publications
(6 citation statements)
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References 79 publications
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“…Cellular signaling pathways were also found enriched in the GSEA, confirming that signaling mechanisms, often found among transcriptomics alterations from PD post mortem brain tissues [31], can also emerge from the analysis of peripheral tissues, such as blood [32, 33].…”
Section: Discussionmentioning
confidence: 71%
“…Cellular signaling pathways were also found enriched in the GSEA, confirming that signaling mechanisms, often found among transcriptomics alterations from PD post mortem brain tissues [31], can also emerge from the analysis of peripheral tissues, such as blood [32, 33].…”
Section: Discussionmentioning
confidence: 71%
“…This study demonstrates that both disease processes and systemic disease factors may affect brain and blood cells in a similar manner. The correlation and corroboration between blood and brain transcriptomic data are further exemplified in a recent study in PD [ 120 ]. Together, these findings identify molecular signatures in PD patients’ brain and blood for potential pathophysiologic and prognostic importance, and these findings may potentially be applicable to other diseases, including AD and MS.…”
Section: Rna Based Microarray Gene Expression Analysismentioning
confidence: 75%
“…Recent studies have identified potential biomarkers, such as the α-synuclein seed amplification assay performed on cerebrospinal fluid – which is therefore invasive - ( 41 ) and a blood transcriptome signature ( 42 ). The distinctive strength of our signature lies in its ability to predict disease severity, particularly the progression of PD cardinal motor symptoms.…”
Section: Discussionmentioning
confidence: 99%