Blood Transfusion and Survival Following Surgery for Renal Carcinoma

Edna, Tom-Harald; Vada, Karsten; Hesselberg, Fredrik; Mjølnerød, Ove Kr.

doi:10.1111/j.1464-410x.1992.tb15690.x

Cited by 30 publications

(26 citation statements)

References 18 publications

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“…Andererseits wurde bei Patienten mit Bluttransfusion (gegenüber solchen ohne Transfusion) über eine höhere postoperative Tumorrezidivrate, eine erhöhte Wahrscheinlichkeit einer Neuerkrankung an malignen Tumoren innerhalb von 3-9 Jahren post transfusionem [12,22,60], ein erhöhtes postoperatives Infektionsrisiko [23] und eine Verminderung der Langzeitüberlebensrate berichtet [11]. Andererseits wurde bei Patienten mit Bluttransfusion (gegenüber solchen ohne Transfusion) über eine höhere postoperative Tumorrezidivrate, eine erhöhte Wahrscheinlichkeit einer Neuerkrankung an malignen Tumoren innerhalb von 3-9 Jahren post transfusionem [12,22,60], ein erhöhtes postoperatives Infektionsrisiko [23] und eine Verminderung der Langzeitüberlebensrate berichtet [11].…”

Section: Bluttransfusion Und Immunkompetenzunclassified

Anästhesie und perioperative Immunfunktion

1998

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Innate and acquired immunity plays a pivotal role in the host defense response. Pain, stress, necrotic tissue and invading microorganisms are known modulators of the complex immune response of patients undergoing major surgery. Anaesthesia itself or perioperative interventions of the anaesthesiologist may substantially alter the immune function with potential impact on the postoperative course. For instance, transfusion of allogenic blood and administration of dopamine or metoclopramide may interfere with immunity. Stress and pain are associated with immune tolerance, increased susceptibility to infection and tumor spreading in animal models. Thus, anaesthesia may--through modulation of the neurohumoral stress response--indirectly affect immunity of the surgical patient. In particular epidural anaesthesia and/or administration of epidural or spinal opioids seem to attenuate the stress response with beneficial effects on cellular and humoral immunity. In addition, anaesthetics, such as etomidate, propofol, or thiopentone and opioid analgesics may directly affect function of immune competent cells. However, these actions may only be apparent with high or supraclinical concentrations and/or long-term exposure. Regarding the latter, evidence suggests that long-term sedation using thiopentone in neurosurgical patients is paralleled by infectious complications in a dose-dependent manner. At present, no data are available regarding the significance of the observed alterations associated with various anaesthetic procedures of the incidence of postoperative complications associated with impaired immunity, such as infection or metastatic spreading in oncological surgery.

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Section: Bluttransfusion Und Immunkompetenzunclassified

Anästhesie und perioperative Immunfunktion

1998

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“…Since that time, many other studies have reported an adverse effect of BT on the prognosis after surgery for various types of cancers (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Others have found only slight or no significant detrimental results on tumor recurrence related to BT (12)(13)(14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

The Influence of Perioperative Blood Transfusion on Intrahepatic Recurrence After Curative Resection of Hepatocellular Carcinoma

Makino

Yamanoi

Kimoto

et al. 2000

American Journal of Gastroenterology

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“…The use of leukocyte-depleted blood significantly reduces this risk [4]. Data on cancer recurrence risk are more equivocal [5][6][7].Advances in surgical techniques together with improved perioperative monitoring and support of cardiopulmonary function combined with hemodilution techniques may reduce [8] but not eliminate the need and use of blood transfusion in surgical practice. Several attempts have been undertaken to reduce the use of homologous blood transfusion by initiating autologous blood transfusion programs, but only a few patients with colorectal cancer can be enrolled in such a program [9].…”

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confidence: 99%