“…With recent knowledge and understanding of the importance of maintaining higher fibrinogen levels, we are using cryoprecipitate earlier in the course of PPH than previously. To date, guidelines have offered different recommendations [46][47][48] and those from the Royal College of Obstetricians and Gynaecologists suggest maintaining the Hb .80 g/L, PT and APTT ,1.5 times the mean control, platelets .75 3 10 9 /L, and fibrinogen .1 g/L. However, these are not evidence based and given that fibrinogen increases in normal pregnancy, with a level at term of 4 to 6 g/L, compared with 1.5 to 4 g/L in the general population, 49,50 this fibrinogen level is likely to be inadequate.…”