Blood transfusion-modulated tumor recurrence: first results of a randomized study of autologous versus allogeneic blood transfusion in colorectal cancer surgery.

Abstract

As indicated by these first results, the blood transfusion modality has a significant effect on tumor recurrence after surgical treatment of colorectal cancer. A change in the practice of blood transfusion might thus potentially surpass the impact of any recent adjuvant treatment strategies.

Major liver resection, systemic fibrinolytic activity, and the impact of tranexamic acid

“…9 In addition, bleeding and blood transfusion are risk factors for postoperative morbidity and in some reports, long-term cancer recurrence. 6,[10][11][12][13][14][15][16][17][18][19][20][21][22] Furthermore, blood products are sometimes scarce and associated with appreciable expense. Thus, there is compelling rationale to reduce blood loss and blood transfusion as much as possible in patients undergoing liver resection.…”

Perioperative management and oncological outcomes following radical cystectomy for bladder cancer: a matched retrospective cohort study

“…[42][43][44] Nevertheless, autologous or leukocyte-depleted transfusions did not improve outcomes for colorectal cancer patients, 45,46 suggesting that other non-immune-mediated factors may be responsible for poor outcomes. 47,48 Based on the information available in the present study, it is not possible to determine whether some unmeasured confounders may have contributed to our findings. Nevertheless, the results of two recent studies showed that perioperative blood transfusions were associated with worse oncological outcomes in patients with bladder cancer, albeit only in univariable analyses.…”

Effects of heme proteins on nitric oxide levels and cell viability in isolated PMNs: a mechanism of toxicity

“…The role of hemolysis of RBCs in transfused blood in the predisposition to infections, multiple organ failure, and recurrence of cancer has been established but is not understood [13,14,66]. Lysed RBCs not only release Hb but also Cu,Zn SOD, catalase, phosphatidyserine, and phosphatidylethanolamine from the inner leaflet of the plasma membrane.…”

“…Hemoglobin (Hb) is released from erythrocytes during hemolytic disorders, burns, and storage of blood for transfusion [7][8][9][10]. In humans, elevated levels of Mb or Hb have been reported to be associated with acute renal failure [11,12], infections, and recurrent cancers in postoperative patients receiving autologous and/or allogeneic transfused blood [13,14]. A recent report of higher mortality in trauma patients transfused with acellular, cross-linked oxyhemoglobin (oxyHb) solutions instead of stored red blood cells (RBCs) emphasizes the importance of elucidating the mechanism of heme protein toxicity [15].…”