Blood Transfusions and Non-Hodgkin's Lymphoma

Chow, Eric J.; Holly, Elizabeth A.

doi:10.1093/epirev/mxf005

Cited by 17 publications

(14 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some have proposed the possibility of introduction of donor lymphoma cells through blood, although a large register-based study of cancer in the donors did not support this hypothesis [29]. Others have suggested that chemical or biological components of transfused blood may cause a temporary immunomodulation [30, 31], promoting lymphoma development, but this hypothesis would not explain why risks remain high many years after transfusion. Emerging evidence has suggested possible associations between viruses and some non-Hodgkin lymphoma cases, including Epstein–Barr virus [32] and again Hepatitis G virus [33, 34], and these viruses are not screened for in transfused blood.…”

Section: Discussionmentioning

confidence: 99%

Cancer risk among 21st century blood transfusion recipients

et al. 2017

View full text Add to dashboard Cite

BackgroundSome carcinogenic viruses are known to be transmissible by blood transfusion. Intensive viral screening of transfused blood now exists in most countries. In the UK, high-sensitivity nucleic acid amplification tests for hepatitis C virus were introduced in 1999 and it was thought that this would reduce, and possibly eliminate, transfusion-related liver cancer. We aimed to investigate cancer risk in recipients of blood transfusion in 2000 or after.MethodsA total of 1.3 million UK women recruited in 1998 on average were followed for hospital records of blood transfusion and for cancer registrations. After excluding women with cancer or precancerous conditions before or at the time of transfusion, Cox regression yielded adjusted relative risks of 11 site-specific cancers for women with compared to without prior blood transfusion.ResultsDuring follow up, 11 274 (0.9%) women had a first recorded transfusion in 2000 or after, and 1648 (14.6%) of them were subsequently diagnosed with cancer, a mean 6.8 years after the transfusion. In the first 5 years after transfusion there were significant excesses for most site-specific cancers examined, presumably because some had preclinical cancer. However, 5 or more years (mean 8 years) after blood transfusion, there were significant excess risks only for liver cancer (adjusted relative risk = 2.63, 95%CI 1.45–4.78) and for non-Hodgkin lymphoma (adjusted relative risk = 1.74, 1.21–2.51). When analyses were restricted to those undergoing hip or knee replacement surgery, the commonest procedure associated with transfusion, these relative risks were not materially altered.ConclusionsIn a large cohort of UK women, transfusions in the 21st century were associated with long-term increased risks of liver cancer and non-Hodgkin lymphoma. Some of these malignancies may have been caused by carcinogenic agents that are not currently screened for in transfused blood.

show abstract

Section: Discussionmentioning

confidence: 99%

Cancer risk among 21st century blood transfusion recipients

et al. 2017

View full text Add to dashboard Cite

show abstract

“…658 Most case-control studies have reported no significant associations between a history of blood transfusions and risk of NHL, with odds ratios ranging between 0.6 and 1.29. [659][660][661][662][663][664] In a casecontrol study of women in Connecticut, no association was found between transfusions and risk of NHL (OR 5 1.0, 95% CI: 0.7-1.3) or any of the NHL types examined, 664 nor was NHL risk associated with number of transfusions, latency or age at first transfusion. Brandt et al 665 reported a significant positive association with transfusions (OR 5 1.74, 95% CI: 1.24-2.44), although no trend was apparent based on time of transfusion prior to NHL diagnosis.…”

Section: Blood Transfusionsmentioning

confidence: 94%

The non-Hodgkin lymphomas: A review of the epidemiologic literature

et al. 2007

View full text Add to dashboard Cite

“…Higher NHL incidence rates have been linked to altered immunity, such as that associated with transplantation, blood transfusion, and immunosuppression (Chow et al 2002; Fisher & Fisher 2004; Grulich et al 2007). Infectious agents such as the Epstein-Barr virus (EBV) are regarded as established causes of NHL, especially in individuals with immune dysfunction (Engels 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Infectious agents such as the Epstein-Barr virus (EBV) are regarded as established causes of NHL, especially in individuals with immune dysfunction (Engels 2007). Between 1971 and the mid-1980s, the number of units of red blood cells and whole blood transfused per unit of population in the US increased over 60 percent, reaching a peak in 1986 and then declining (Chow & Holly 2002; Surgenor et al 1990). EBV infection is not commonly seen outside of endemic areas, typically in Africa, and mostly is related to Burkitt’s lymphomas.…”

Section: Discussionmentioning

confidence: 99%

Temporal and Demographic Patterns of Non-Hodgkin's Lymphoma Incidence in Pennsylvania

Han

Dinse²,

Davis³

2010

International Journal of Occupational and Environmental Health

View full text Add to dashboard Cite

Objective Our study analyzed temporal and demographic patterns of non-Hodgkin’s lymphoma (NHL) incidence in Pennsylvania and compared Pennsylvania time trends with national trends. Methods Joinpoint and age-period-cohort analyses summarized sex- and race-specific NHL incidence time trends between 1985 and 2004. Ecologic analysis identified demographic factors associated with age-adjusted county-specific NHL incidence. Results NHL incidence in Pennsylvania increased annually 1.6% and 2.5% in white and black men and 1.6% and 3.2% in white and black women. National trends were similar, except for smaller increases in white men. Diffuse lymphoma appeared to be the major contributor to the increases. NHL incidence was higher in Pennsylvania counties with greater percentages of urban residents. Conclusions NHL incidence patterns in Pennsylvania were parallel to those seen nationally, with the highest rates occurring in white men and in persons residing in urban areas.

show abstract

Blood Transfusions and Non-Hodgkin's Lymphoma

Cited by 17 publications

References 61 publications

Cancer risk among 21st century blood transfusion recipients

Cancer risk among 21st century blood transfusion recipients

The non-Hodgkin lymphomas: A review of the epidemiologic literature

Temporal and Demographic Patterns of Non-Hodgkin's Lymphoma Incidence in Pennsylvania

Contact Info

Product

Resources

About