Blood-Transfusions Induce Prolonged Kidney Allograft Survival in Rhesus Monkeys

Anti-Class II Antibody Production Prolongs Renal Allograft Survival

“…In contrast, Jeffery et al [25] found no correla tion between the number of transfusions and magnitude of the mixed lymphocyte re sponse. The phenomenon of prolonged renal allograft surivival following blood transfu sion was postulated by Van Es et al [4] to be immunologically nonspecific since RhLA product sharing between blood and kidney donors in rhesus monkeys was less than could be expected for immunologic enhance ment. Keown and Descamps [6] suggested a nonspecific RBC-mediated modulation of the immune response reflecting the RBCfilled macrophage's impaired antigen pro cessing and phagocytic function.…”

“…Whereas Horimi et al [29] showed that cytotoxic antibodies were not necessarily injurious to renal allotransplants, there was a slightly diminished graft survival rate in recipients manifesting warm reactive anti-T lymphocyte antibodies. In the rhesus monkey, Van Es et al [4] argued against B cell alloantibodies extending allograft sur vival, as no correlation was observed be tween positive B cell crossmatches and pro longed graft survival.…”

“…It is widely accepted that conditioning of recipients by blood transfusions exerts a fa vorable influence on the survival of renal allotransplants [1][2][3][4][5][6][7], In the past, some in vestigators suggested that the beneficial ef fect of transfusions was only the result of selection, and many patients were thought to be rendered nontransplantable as a conse quence of sensitization by transfusions [8][9][10][11][12], A low rate of rejection in some studies does not support a selecting out process as the mechanism for improved allograft sur vival and argues for a modification of the immunologic responses [13], The effects of blood transfusions are found to improve the outcome, especially in the best HLAmatched groups [5], In contrast, others de scribed a highly significant allograft survival in the transfused DR-mismatched cadaveric kidney allograft recipients [14], Many au thors have suggested that H LA-DR antigen matching alone improves allograft survival [15][16][17][18][19][20], However, this finding is not univer sal [21]. The timing of transfusions as well as the number of units of blood needed for opti mum graft survival are still unresolved.…”

One Hundred Kidney Transplants in the Belfast City Hospital

“…There is no doubt that the patients required more blood transfusions after the nephrectomy and there have been many recent suggestions that blood transfusion improves graft survival in patients (Festenstein, Sachs, Paris, Pegrum and Moorehead, 1976;Opelz and Terasaki, 1976;van Hooff, Kalff and van Poelgeaste, 1976) and in animals (van Es, Marquet, van Rood, Kalff and Balner, 1977). We have noted that the incidence of urinary tract infection is lower amongst our nephrectomised patients (Douglas, Clarke, Kennedy, McEvoy and McGeown, 1974) than in other series (Hamshere, Chisholm and Shackman, 1974;Steen, Pedersen and Vejlsgaard, 1975).…”

The Enigma of Good Kidney-Graft Survival in the Face of Poor HLA Matches

“…Furthermore, a randomized prospective study in rhesus monkeys that received five blood transfusions over a 3-month period prior to transplantation and Standard immunosuppression after transplantation showed a significant fourfold Prolongation of graft survival ( Fig. 2) (van Es et al, 1977).…”