Blood type association with bleeding outcomes at delivery in a large multi-center study

Bade, Najeebah A.; Kazma, Jamil; Amdur, Richard L.; Ellis-Kahana, Julia; Ahmadzia, Homa K.

doi:10.1007/s11239-019-02023-4

Cited by 7 publications

(10 citation statements)

References 31 publications

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“…There was no increased blood loss in patients with particular blood group. This observation in cardiovascular surgery was in contrast to the previous reports in postpartum blood loss [11,12]. Prospective further studies taking into account coagulation profile are necessary to determine whether ABO system can be considered a heritable risk of perioperative period hemorrhage.…”

Section: Discussioncontrasting

confidence: 73%

Use of laboratory testing for prediction of postoperative bleeding volume in cardiovascular surgery

et al. 2021

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Background Coagulopathy and following massive bleeding are complications of cardiovascular surgery, particularly occurring after procedures requiring prolonged cardiopulmonary bypass (CPB). Reliable and rapid tests for coagulopathy are desirable for guiding transfusion. Measuring multiple coagulation parameters may prove useful. The purpose of this study is to determine the laboratory parameters predicting massive bleeding. Methods In a prospectively collected cohort of 48 patients undergoing cardiovascular surgery, markers of coagulation and fibrinolysis were measured using automated analyzer and their correlations with bleeding volume were determined. Results Operation time was 318 (107–654) min. CPB time was 181 (58–501) min. Bleeding volume during surgery was 2269 (174–10,607) ml. Number of transfusion units during surgery were packed red blood cells 12 (0–30) units, fresh frozen plasma 12 (0–44) units, platelets 20 (0–60) units and intraoperative autologous blood collection 669 (0–4439) ml. Post-surgery activities of coagulation factors II (FII), FV, FVII, FVIII, FIX, FX, FXI and FXII were decreased. Values of fibrinogen, antithrombin, α2 plasmin inhibitor (α2PI) and FXIII were also decreased. Values of thrombin-antithrombin complex (TAT) were increased. Values of FII, FIX, FXI and α2PI before surgery were negatively correlated with bleeding volume (FII, r = − 0.506: FIX, r = − 0.504: FXI, r = − 0.580; α2PI, r = − 0.418). Level of FIX after surgery was negatively correlated with bleeding volume (r = − 0.445) and level of TAT after surgery was positively correlated with bleeding volume (r = 0.443). Conclusions These results suggest that several clinical and routine laboratory parameters of coagulation were individually associated with bleeding volume during cardiovascular surgery. Determining the patterns of coagulopathy may potentially help guide transfusion during cardiovascular surgery.

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Section: Discussioncontrasting

confidence: 73%

Use of laboratory testing for prediction of postoperative bleeding volume in cardiovascular surgery

et al. 2021

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“…Some studies reported a higher bleeding risk in patients with type O blood who experienced upper gastrointestinal haemorrhage [12,13]. Other studies reported higher postpartum blood loss: Kahr et al [5] found that women with type O blood had greater postpartum blood loss than women with non‐O type blood; Drukker et al [6] found that women with type O blood were at 1·14‐fold greater risk of postpartum haemorrhage; and Bade et al [7] found that women undergoing caesarean delivery had significantly more blood loss if they had type O blood rather than type non‐O blood and that type O blood was associated with a 1·09‐fold greater risk for transfusion than type non‐O blood. In contrast, other studies in patients with peptic ulcer bleeding [14] or cerebral haemorrhage [15] or after cardiac surgery [16] did not confirm such increases in bleeding tendency associated with type O blood.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the tendency that VTE is unlikely to occur in patients with type O blood may mean, conversely, that those patients have a predisposition to bleeding and a higher incidence of bleeding problems than patients with non-O blood types. While some investigators in gynaecology reported that women with type O blood suffer greater postpartum blood loss than women with other blood types [5][6][7][8], whether individuals with type O blood experience increased bleeding remains to be clarified. Here, we report an association of ABO blood group with Correspondence: Katsuhiko Maezawa, Orthopaedic Surgery, Juntendo University Urayasu Hospital, Urayasu, Japan.…”

Section: Introductionmentioning

confidence: 99%

Association of ABO blood group with postoperative total bleeding volume in patients undergoing total hip arthroplasty

et al. 2021

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Background and objectives As individuals with blood types A, B and AB have approximately 25% higher levels of vWF than those with type O, the risk of developing venous thrombotic events has been investigated in a number of clinical studies, but whether individuals with type O blood experience increased bleeding remains to be clarified. The purpose of this study was to evaluate an association of ABO blood group with intraoperative bleeding and postoperative total bleeding in patients undergoing total hip arthroplasty. Materials and methods We prospectively recruited 84 women who were undergoing total hip arthroplasty. The differences between blood groups in mean age, body weight, preoperative and postoperative Hct levels, and postoperative/preoperative Hct ratio, intraoperative bleeding volume (IBV), and total bleeding volume (TBV) were evaluated. Results Twenty‐six patients had type A blood, 17 had type B, 9 had type AB, and 30 had type O. There were no significant differences in mean age, body weight or operating time between the different ABO blood groups. While there was no significant difference in these Hct levels or IBV among the different blood groups, there was a significant difference in TBV between type O and type AB, and between type O and non‐type O. Conclusion Our study in patients undergoing total hip arthroplasty suggests that patients in blood group O tend to have large amounts of bleeding.

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“…Women with blood type O seemed to get more attention during pregnant because of the lower content of Factor VIII and von Willebrand factor [20]. Studies have shown blood type O to be independently associated with a risk for parturient hemorrhage [17,[21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Blood Type and Outcomes in Pregnant Women with Placenta Previa

Fan

Rao

Zhang

et al. 2023

Oxidative Medicine and Cellular Longevity

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Background. Placenta previa increases the risks of obstetrical complications. Many studies have reported a link between various ABO blood types and pregnancy complications. This study is aimed at describing and comparing the characteristics and outcomes of women with placenta previa by ABO blood type. Methods. Data for this study was obtained from a retrospective cohort study between January 1, 2014, and June 30, 2019, of all clinically confirmed placenta previa in a university-based tertiary medical center. Both types of A, B, O, AB, and combining O and non-O blood types were compared to the characteristics and outcomes. Results. 1678 participants with placenta previa were included in this study. The highest participants were blood type O with 666 (39.7%), followed by type A with 508 (30.3%) and type B with 395 (23.5%), and the lowest participants were AB with 109 (6.5%). Blood type AB had a higher incidence of antepartum hemorrhage ( p = 0.017 ), predelivery anemia ( p = 0.036 ), and preterm birth ( p = 0.015 ) in placenta previa women. Meanwhile, the incidence of rhesus D positive (97.9% vs. 95.8%, p = 0.012 ) and twins (5.0% vs. 2.7%, p = 0.011 ) was higher in the non-O group, and the incidence of neonatal asphyxia (5.9% vs. 9.2%, p = 0.016 ) was lower in the non-O group. Conclusion. Type AB blood may be a potential risk factor for women with placenta previa. This finding may help provide any obstetrician to predict the risk of complication for placenta previa women by the ABO blood types.

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Blood type association with bleeding outcomes at delivery in a large multi-center study

Cited by 7 publications

References 31 publications

Use of laboratory testing for prediction of postoperative bleeding volume in cardiovascular surgery

Use of laboratory testing for prediction of postoperative bleeding volume in cardiovascular surgery

Association of ABO blood group with postoperative total bleeding volume in patients undergoing total hip arthroplasty

Blood Type and Outcomes in Pregnant Women with Placenta Previa

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