Blood urea nitrogen/albumin ratio on admission predicts mortality in patients with non ST segment elevation myocardial infarction

Satar, Salim; Gülen, Müge; Acehan, Selen; Acele, Armağan; Şahin, Gonca Köksaldi; Satar, Deniz Aka

doi:10.1080/00365513.2022.2122075

Cited by 9 publications

(12 citation statements)

References 42 publications

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“…3,6,32 Capodanno et al 6 found that the SX score significantly predicted the risk of cardiac death (hazard ratio, 1.12/unit increase; 95% CI: , it was found that the number of affected vessels (P < 0.001), the incidence of LMCA lesions (P < 0.001) and mortality (P < 0.001) were higher and statistically significant in cases with a cut-off value of more than 17.75 for the SX score. 26 In our study, it was found that as the SX score increased, patients needed coronary bypass graft treatment more frequently, and the number of days of hospitalization and mortality increased. Also, the number of affected vessels in CAG and the incidence of LMCA lesions were higher in patients with an SX score of at least 19.75.…”

Section: Discussionmentioning

confidence: 56%

“…Capodanno et al 6 found that the SX score significantly predicted the risk of cardiac death (hazard ratio, 1.12/unit increase; 95% CI: 1.06--1.18; P < 0.001) and MACE (hazard ratio, 1.59/unit increase; 95% CI: 1.02--2.48; P = 0.043). In a prospective study with NSTEMI patients ( n = 415) conducted by Sevdimbas et al , it was found that the number of affected vessels ( P < 0.001), the incidence of LMCA lesions ( P < 0.001) and mortality ( P < 0.001) were higher and statistically significant in cases with a cut-off value of more than 17.75 for the SX score 26 . In our study, it was found that as the SX score increased, patients needed coronary bypass graft treatment more frequently, and the number of days of hospitalization and mortality increased.…”

Section: Discussionmentioning

confidence: 97%

“…Although the BAR has been shown to have an important prognostic value in recent studies with critically ill patients, there are not enough studies in the literature on STEMI patients. Sevdimbas et al 26 reported that the BAR (OR: 1.280, 95% CI: 1.113–1.472, P = 0.001) was an independent predictor of 30-day mortality in patients with NSTEMI. In another study in which the prognostic value of the BAR was compared with the acute physiology score III, systemic inflammatory response syndrome and sequential organ failure assessment in patients with acute myocardial infarction, it was found that the AUC value of the BAR was higher compared with these scores 38 .…”

Section: Discussionmentioning

confidence: 99%

“…The BUN/albumin ratio (BAR), which is the mathematical ratio of BUN and albumin, is a new prognostic inflammatory biomarker that has been found to have a good predictive effect on the mortality of patients. There are studies in the literature investigating the effect of the BAR value on predicting mortality and prognosis such as COVID-19, 20 sepsis, 21 HIV, 22 pneumonia, 23 pulmonary embolism, 24 aortic dissection, 25 and NSTEMI 26 …”

Section: Introductionmentioning

confidence: 99%

“…There are studies in the literature investigating the effect of the BAR value on predicting mortality and prognosis such as COVID-19, 20 sepsis, 21 HIV, 22 pneumonia, 23 pulmonary embolism, 24 aortic dissection, 25 and NSTEMI. 26 The aim of this study is to compare the prognostic power of the BAR calculated on admission to the emergency department and the SX score calculated after coronary angiography (CAG) in predicting 30-day mortality in patients with STEMI.…”

Section: Introductionmentioning

confidence: 99%

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BUN/albumin ratio predicts short-term mortality better than SYNTAX score in ST-elevation myocardial infarction patients

Balcik

Satar

Gülen

et al. 2023

Journal of Cardiovascular Medicine

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ObjectiveThe aim of the study is to compare the prognostic power of the BUN/albumin ratio (BAR) calculated on admission to the emergency department and the SYNergy between Percutaneous Coronary Intervention with TAXus (SYNTAX) score calculated after coronary angiography (CAG) in predicting 30-day mortality in patients with ST-segment elevation myocardial infarction (STEMI).Method and MaterialThe study was conducted prospectively between March 2021 and March 2022 in the emergency department of a tertiary hospital. Patients over the age of 18 who underwent CAG with a diagnosis of STEMI were included in the study. Demographic charecteristics, comorbidities, laboratory parameters of the patients at the time of admission and SYNTAX (SX) score were recorded in the data form.ResultsA total of 1147 patients (77% male) diagnosed with STEMI were included in the study. When the receiver-operating characteristic analysis for SX score and laboratory parameters’ power to predict mortality was examined, it was found that the AUC value of the BAR level (AUC: 0.736; 95% confidence interval: 0.670–0.802, P < 0.001) was the highest. If the threshold value of the serum BAR level, which was determined to predict mortality, was taken as 4, the sensitivity was found to be 76.7% and the specificity was 56.9%. With multivariate logistic analysis, it was determined that the risk of mortality increased by 1.25 for each unit increase in the BAR value in STEMI patients (P < 0.001).ConclusionAccording to the study data, the BAR may guide the clinician in the early period as a practical and valuable predictor of 30-day mortality in patients diagnosed with STEMI.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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BUN/albumin ratio predicts short-term mortality better than SYNTAX score in ST-elevation myocardial infarction patients

Balcik

Satar

Gülen

et al. 2023

Journal of Cardiovascular Medicine

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Urea nitrogen‐to‐albumin ratio predicts ventricular aneurysm formation in ST‐segment elevation myocardial infarction

Zhang,

Yang,

et al. 2024

ESC Heart Failure

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AimsLeft ventricular aneurysm (LVA) is an important complication of acute myocardial infarction. The aim of this study was to investigate the possible predictive value of blood urea nitrogen‐to‐albumin ratio (BAR) for the LVA formation in acute ST‐segment elevation myocardial infarction (STEMI) patients who underwent primary percutaneous coronary intervention (PCI).Methods and resultsA total of 1123 consecutive patients with STEMI were prospectively enrolled. The clinical and laboratory data were compared between LVA group and non‐LVA group. Multivariable logistic regression analysis was performed to assess the independent risk factors of LVA formation. Predictive power of BAR and composite variable for LVA formation were assessed using receiver operating characteristic curve. LVA was detected in 162 patients (14.4%). The BAR was significantly higher in patients with LVA [0.16 (0.13–0.19) vs. 0.13 (0.10–0.17), P < 0.001]. Multivariable logistic regression analysis revealed that left ventricular ejection fraction (LVEF) [odds ratio (OR) = 0.865, P < 0.001], culprit vessel–left anterior descending artery (LAD) (OR = 4.705, P < 0.001), and BAR (OR = 2.208, P = 0.018) were all independent predictors for LVA formation. The predictive value of BAR remained significant even after cross‐validation by splitting population into training set (OR = 1.957, P = 0.034) and validation set (OR = 1.982, P = 0.039). The maximal length and width of LVA were significantly increased in patients with BAR ≥ 0.15 when compared with BAR < 0.15 (3.37 ± 1.09 vs. 2.92 ± 0.93, P = 0.01, for maximal length, and 2.20 ± 0.55 vs. 1.85 ± 0.63, P = 0.001, for maximal width). The discriminant power of BAR for LVA is 0.723, which is superior to both blood urea nitrogen (C statistic = 0.586, P < 0.001) and albumin (C statistic = 0.64, P < 0.001). The combination of BAR, LVEF, and culprit vessel–LAD could significantly increase the predictive ability (C statistic = 0.874, P < 0.001, for vs. BAR). Subgroup analysis of age, sex, hypertension, diabetes, smoking, LVEF, serum albumin, multiple‐vessel disease, and Gensini score had no effect on the association between BAR and risk of LVA formation (P < 0.05 for all subgroups).ConclusionsA higher BAR was an independent predictor for LVA formation in STEMI patients with primary PCI.

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Acute kidney injury and COVID-19: the predictive power of BUN/albumin ratio for renal replacement therapy requirement

Acehan

2024

Ir J Med Sci

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Blood urea nitrogen/albumin ratio on admission predicts mortality in patients with non ST segment elevation myocardial infarction

Cited by 9 publications

References 42 publications

BUN/albumin ratio predicts short-term mortality better than SYNTAX score in ST-elevation myocardial infarction patients

BUN/albumin ratio predicts short-term mortality better than SYNTAX score in ST-elevation myocardial infarction patients

Urea nitrogen‐to‐albumin ratio predicts ventricular aneurysm formation in ST‐segment elevation myocardial infarction

Acute kidney injury and COVID-19: the predictive power of BUN/albumin ratio for renal replacement therapy requirement

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