Blood use in hematologic malignancies: a nationwide overview in Sweden between 2000 and 2010

Zhao, Jingcheng; Rydén, Jenny; Wikman, Agneta; Norda, Rut; Stanworth, Simon; Hjalgrim, Henrik; Edgren, Gustaf

doi:10.1111/trf.14440

Cited by 9 publications

(13 citation statements)

References 16 publications

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“…Over two‐thirds of the MDS patients require more than one RBC transfusion over the course of the disease . Considering the clinical significance of transfusion intensity, which was recently demonstrated, the negative impact on health‐related quality of life and that the direct costs of transfusions are substantial, it is important to optimize transfusion therapy to these patients.…”

Section: Methodsmentioning

confidence: 99%

A longer duration of red blood cell storage is associated with a lower hemoglobin increase after blood transfusion: a cohort study

et al. 2019

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BACKGROUND: RBC concentrates are commonly stored for up to 42 days but there has been conflicting evidence on the effect of storage duration and clinical outcomes. Most clinical studies have focused on possible associations between duration of storage time and risk for adverse outcomes, including mortality. Recent clinical trials did not find any such associations, but fewer studies have addressed whether storage time affects component efficacy. The main aim of this study was to determine the effect of RBC storage time on hemoglobin increment in transfused patients. STUDY DESIGN AND METHODS: Transfusion dataon a cohort of patients with myelodysplastic syndromes were linked to hemoglobin measurements taken between 2 days before and 28 days after a transfusion episode. We applied a mixed-effect linear regression model, accounting for patient characteristics and time from transfusion to next hemoglobin measurement, to study the effect of RBC storage on the hemoglobin increment.ABBREVIATION: MDSs = myelodysplastic syndromes.From the

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Section: Methodsmentioning

confidence: 99%

A longer duration of red blood cell storage is associated with a lower hemoglobin increase after blood transfusion: a cohort study

et al. 2019

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“…Zhao et al . reported that the median number of transfused RBC units was zero for their cohort, with an average of 7·5 units . Our study had greater variation in the duration of follow‐up compared to the Swedish study, or 1 month‐14 years compared to 2·6–7·3 years.…”

Section: Discussionmentioning

confidence: 61%

“…In our cohort of CLL patients, one‐third required RBC transfusions during the course of the study compared to 44% of CLL patients in the study by Zhao et al . of 5253 Swedish CLL patients . The median number of transfused RBC units in our study was six for the transfused subgroup and zero for the whole cohort.…”

Section: Discussionmentioning

confidence: 73%

“…[18,19]. Recently, one population-based overview of blood use in haematological malignancies in Sweden by Zhao et al showed high variability depending on diagnosis and age [13]. Such population-based studies on the current blood use can give valuable information, as considerable intercentre and disease-dependent variation can be expected.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with haematological disorders account for 6Á9-8Á8% of red cell units transfused according to recent studies [10,11]. Not many studies have been published on RBC transfusion practises in haematological malignancies and still fewer for specific diseases like CLL [12,13]. RBC transfusions are not without risks and in recent years increased emphasis has been on the conservative use of blood components, or patient blood management (PBM) [14].…”

Section: Introductionmentioning

confidence: 99%

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Red blood cell utilization and transfusion triggers in patients diagnosed with chronic lymphocytic leukaemia in Iceland 2003–2016

et al. 2019

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Background and Objectives Revised Icelandic guidelines proposed a restrictive haemoglobin (Hb) threshold of 70 g/l for red blood cell (RBC) transfusions in general, but 100 g/l for malignancies/bone marrow suppression. Chronic lymphocytic leukaemia (CLL) is frequently complicated by anaemia. The objective was to investigate RBC transfusion practices in CLL. Materials and methods This retrospective nation‐wide study utilized an Icelandic registry of CLL patients diagnosed between 2003 and 2016. Medical records were reviewed and haemoglobin transfusion triggers compared for two periods: Earlier (2003–2012) and latter (2013–2017). Results Two hundred and thirteen patients were diagnosed with CLL over the period whereof 77 (36·2%) received RBC transfusion(s). Median time from diagnosis to first transfusion was 2·2 years. Higher age, Rai stage 3/4 at diagnosis (P < 0·05) and chemotherapy (P < 0·001) were associated with increased odds of transfusions. Shorter time to first transfusion correlated with higher age (P < 0·001) and Rai stage (P = 0·02) at diagnosis. The mean Hb trigger was 90·4 and 81·2 in the earlier and latter period respectively (P = 0·01). This difference in Hb triggers was most pronounced in patients without documented bone marrow involvement, or 80·5 g/l compared to 93·5 g/l (P = 0·004). The median time from diagnosis to transfusion was longer in the latter period (2·9 years vs. 1·6 years, P = 0·01). After RBC transfusions the survival decreased significantly (P < 0·001). Conclusion One‐third of CLL patients received RBC transfusions but few were heavily transfused. Older age, Rai stage, and chemotherapy predicted RBC use. The Hb transfusion trigger decreased over time while time to first RBC transfusion increased. RBC transfusions predict poor survival.

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Male sex and the pattern of recurrent myeloid mutations are strong independent predictors of blood transfusion intensity in patients with myelodysplastic syndromes

et al. 2018

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Blood use in hematologic malignancies: a nationwide overview in Sweden between 2000 and 2010

Abstract: Results from this population-based overview of blood use in hematologic malignancies showed high variability depending on diagnosis and age.

Cited by 9 publications

References 16 publications

A longer duration of red blood cell storage is associated with a lower hemoglobin increase after blood transfusion: a cohort study

A longer duration of red blood cell storage is associated with a lower hemoglobin increase after blood transfusion: a cohort study

Red blood cell utilization and transfusion triggers in patients diagnosed with chronic lymphocytic leukaemia in Iceland 2003–2016

Male sex and the pattern of recurrent myeloid mutations are strong independent predictors of blood transfusion intensity in patients with myelodysplastic syndromes

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