Blood Vessel Deformations on Microsecond Time Scales by Ultrasonic Cavitation

Chen, Hong; Kreider, Wayne; Brayman, Andrew A.; Bailey, Michael R.; Matula, Thomas J.

doi:10.1103/physrevlett.106.034301

Cited by 281 publications

(229 citation statements)

References 20 publications

Supporting

Mentioning

215

Contrasting

Unclassified

Order By: Relevance

“…One may assume that the disruption occurs due to bubble growth and corresponding distension of the vessel wall. However, it was shown that most damage occurs as the bubble rapidly collapses and the vessel wall is bent inward or invaginated, causing high amplitude shear stress (27).…”

Section: Acoustic Cavitationmentioning

confidence: 99%

HIFU for Palliative Treatment of Pancreatic Cancer

Khokhlova

Hwang

2016

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

KEY WORDSHigh intensity focused ultrasound (HIFU) is a novel non-invasive modality for ablation of various solid tumors including uterine fibroids, prostate cancer, hepatic, renal, breast and pancreatic tumors. HIFU therapy utilizes mechanical energy in the form of a powerful ultrasound wave that is focused inside the body to induce thermal and/or mechanical effects in tissue. Multiple preclinical and non-randomized clinical trials have been performed to evaluate the safety and efficacy of HIFU for palliative treatment of pancreatic tumors. Substantial tumor-related pain reduction was achieved in most cases after HIFU treatment, and no significant side-effects were observed. This review provides a description of different physical mechanisms underlying HIFU therapy, summarizes the clinical experience obtained to date in HIFU treatment of pancreatic tumors, and discusses the challenges, limitations and new approaches in this modality. therapeutic ultrasound; focused ultrasound; HIFU; pancreas cancer; review J Gastrointest Oncol 2011; 2: 175-184.

show abstract

Section: Acoustic Cavitationmentioning

confidence: 99%

HIFU for Palliative Treatment of Pancreatic Cancer

Khokhlova

Hwang

2016

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

show abstract

“…Microbubbles exert forces on the vessels to a much larger extend and can generate liquid microjets. 16 This IC behavior is more forceful and may increase BBB permeability to a larger extent. IC has been shown to be associated with microdamage to the cerebral vessels.…”

Section: Introductionmentioning

confidence: 99%

The Size of Blood–Brain Barrier Opening Induced by Focused Ultrasound is Dictated by the Acoustic Pressure

Chen

Konofagou

2014

J Cereb Blood Flow Metab

Self Cite

227

195

View full text Add to dashboard Cite

Focused ultrasound (FUS) in combination with microbubbles (MBs) has been successfully used in the delivery of various-size therapeutic agents across the blood-brain barrier (BBB). This study revealed that FUS-induced BBB opening size, defined by the size of the largest molecule that can permeate through the BBB, can be controlled by the acoustic pressure as dictated by cavitational mechanisms. Focused ultrasound was applied onto the mouse hippocampus in the presence of systemically administered MBs for trans-BBB delivery of fluorescently labeled dextrans with molecular weights 3 to 2,000 kDa (hydrodynamic diameter: 2.3 to 54.4 nm). The dextran delivery outcomes were evaluated using ex vivo fluorescence imaging. Cavitation detection was employed to monitor the MB cavitation activity associated with the delivery of these agents. It was found that the BBB opening size was smaller than 3 kDa (2.3 nm) at 0.31 MPa, up to 70 kDa (10.2 nm) at 0.51 MPa, and up to 2,000 kDa (54.4 nm) at 0.84 MPa. Relatively smaller opening size (up to 70 kDa) was achieved with stable cavitation only; however, inertial cavitation was associated with relatively larger BBB opening size (above 500 kDa). These findings indicate that the BBB opening size can be controlled by the acoustic pressure and predicted using cavitation detection.

show abstract

“…If microbubbles collapse near a blood vessel wall, the shock wave may create liquid jets that affect the vessel, creating holes in the vessel wall (38). Therefore, the expansion, oscillation and collapse of the bubbles and the resultant microstreaming, shock wave and fluid jets altogether result in microvessel distention, invagination and ultimately vessel rupture (12,18,20,29,38). …”

Section: Discussionmentioning

confidence: 99%

“…Although there are certain studies that have investigated microbubble parameters, including size or shell properties or ultrasound pulse parameters, including the fundamental transmission frequency, pulse repetition frequency, duty cycle, pulse length, mechanical index and acoustic peak negative acoustic pressure (8,(10)(11)(12)(13), these studies investigated few parameters simultaneously and did not investigate the different combinations of various levels of parameters. In addition, these studies focused only on the therapeutic effects of USMB, and seldom considered the damage to the skin induced by USMB.…”

Section: Introductionmentioning

confidence: 99%

Optimization of low-frequency low-intensity ultrasound-mediated microvessel disruption on prostate cancer xenografts in nude mice using an orthogonal experimental design

Bai

Chen

et al. 2015

Oncology Letters

View full text Add to dashboard Cite

Abstract. The present study aimed to provide a complete exploration of the effect of sound intensity, frequency, duty cycle, microbubble volume and irradiation time on low-frequency low-intensity ultrasound (US)-mediated microvessel disruption, and to identify an optimal combination of the five factors that maximize the blockage effect. An orthogonal experimental design approach was used. Enhanced US imaging and acoustic quantification were performed to assess tumor blood perfusion. In the confirmatory test, in addition to acoustic quantification, the specimens of the tumor were stained with hematoxylin and eosin and observed using light microscopy. The results revealed that sound intensity, frequency, duty cycle, microbubble volume and irradiation time had a significant effect on the average peak intensity (API). The extent of the impact of the variables on the API was in the following order: Sound intensity; frequency; duty cycle; microbubble volume; and irradiation time. The optimum conditions were found to be as follows: Sound intensity, 1.00 W/cm 2 ; frequency, 20 Hz; duty cycle, 40%; microbubble volume, 0.20 ml; and irradiation time, 3 min. In the confirmatory test, the API was 19.97±2.66 immediately subsequent to treatment, and histological examination revealed signs of tumor blood vessel injury in the optimum parameter combination group. In conclusion, the Taguchi L 18 (3) 6 orthogonal array design was successfully applied for determining the optimal parameter combination of API following treatment. Under the optimum orthogonal design condition, a minimum API of 19.97±2.66 subsequent to low-frequency and low-intensity mediated blood perfusion blockage was obtained.

show abstract

Blood Vessel Deformations on Microsecond Time Scales by Ultrasonic Cavitation

Cited by 281 publications

References 20 publications

HIFU for Palliative Treatment of Pancreatic Cancer

HIFU for Palliative Treatment of Pancreatic Cancer

The Size of Blood–Brain Barrier Opening Induced by Focused Ultrasound is Dictated by the Acoustic Pressure

Optimization of low-frequency low-intensity ultrasound-mediated microvessel disruption on prostate cancer xenografts in nude mice using an orthogonal experimental design

Contact Info

Product

Resources

About