Blood volume and age: repeated measurements on normal men after 17 years.

Chien, Shu; Usami, Shunsuke; Simmons, R L; McAllister, Ferdinand F.; Gregersen, Magnus I.

doi:10.1152/jappl.1966.21.2.583

Cited by 63 publications

(13 citation statements)

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“…However, this is without importance with regard to the TER values and plasma albumin concentrations, since these variables in adults are largely age independent (Parving, 1975;Weeke & Krasilnikoff, :[972). While the individual plasma volume expressed in absolute terms is relatively constant dtiring adult life (Chien et al, 1966;Sjostrand, 1963), plasma volume expressed in relation to body weight is age dependent due to increasing body weight with age (Sjostrand, 1963). This disturbing influence can be avoided by expressing plasma volume and IVM in relation to body height as done in the present study.…”

Section: Methodsmentioning

confidence: 99%

Plasma volume, intravascular albumin and its transcapillary escape rate in patients with extensive skin disease

1976

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Plasma volume and plasma concentration and transcapillary escape rate of albumin (TER alb), i.e. the fraction of intravascular mass of albumin that passes to the extravascular space per unit time, were determined using 125I-labelled human albumin in eight patients with extensive skin disease. Plasma volume and plasma albumin concentration were reduced (P less than 0-05). Thus the intravascular albumin mass was moderately decreased to an average of 0-55 +/- 0-06 (s.d.) g/cm height compared with a normal mean value of 0-77 +/- 0-07 (s.d.) g/cm. This 29% decrease is statistically significant (P less than 0-001). The transcapillary escape rate of albumin (TER alb) was significantly elevated, mean 8-6 +/- 1-1 (s.d.) % X h-1, as compared to normal subjects, mean 5-6 +/- 1-1 (s.d.) % X h-1, (+54%, P less than 0-001). The same patients were studied again after a 1-week treatment with prednisone, 25-60 mg per day. Plasma albumin concentration, plasma volume and intravascular mass of albumin were unchanged, while TER alb decreased significantly during treatment, mean 5-9 +/- 0-8 (s.d.) % X h-1, (P less than 0-01). It is suggested that displacement of albumin into the skin and loss of albumin from the skin are the dominating mechanisms of the reduction in the intravascular albumin mass in patients with extensive skin disease.

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Section: Methodsmentioning

confidence: 99%

Plasma volume, intravascular albumin and its transcapillary escape rate in patients with extensive skin disease

1976

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“…100 A contrary view has arisen from the studies of Helderman et al, 102 in which an increase in the sensitivity of the osmoreceptors that regulate the release of AVP release was observed. 105 Cross-sectional and longitudinal studies have revealed that plasma and blood volume do not alter as a result of age alone in healthy men, 106 although Worum and colleagues 107 found that elderly women had a significantly greater plasma volume than young women. Age diminishes the sensitivity of the baroreceptors and the release of AVP mediated by them.…”

Section: Water Balancementioning

confidence: 99%

The normal ageing kidney – morphology and physiology

Núñez

2008

Rev. Clin. Gerontol.

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“…port. Plasma optical density was measured before and after injection of albumin-bound T-1824 (Evan's Blue) solution using a modified version of the method of Chien et al [13]. Analysis of blood samples was carried out immediately after testing.…”

Section: Vascular Volumesmentioning

confidence: 99%

Short-term aerobic training and circulatory function in women: age and hormone-replacement therapy

et al. 2003

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The physiological basis of training responses in women, and particularly older women, is not well understood. Short-term aerobic training (STAT) was used to probe the effects of age and hormone-replacement therapy (HRT) on women's ability to rapidly change peak uptake ( VO(2max)), plasma volume and cardiac function. A total of 39 females participated in the STAT programme: 15 younger (Y; aged 19-29 years), 12 postmenopausal women undergoing HRT and 12 non-medicating postmenopausal (PM) women (aged 60-75 years). Training consisted of ten sessions of cycling over a 2-week period, which progressed in duration from 20 to 60 min and in intensity from 60-75% of maximum heart rate. Plasma volume (PV; as determined by Evan's Blue dye dilution), VO(2max) (cycle ergometry) and cardiac function (radionuclide ventriculography) were analysed using analysis of covariance or repeated measures ANOVA. All groups demonstrated similar increase in VO(2max) (Y, 13%; PM, 17%; HRT, 13%), but without a significant change in left-ventricular ejection fraction and diastolic function or volumes during supine exercise. PV expansion was observed among the Y group (7%; P <0.05) but not the PM group (2%; P >0.05) or women undergoing HRT (1%; P >0.05). Age and hormone-replacement status did not affect the magnitude of VO(2max) change. This study suggests that STAT improves VO(2max), independent of central adaptations.

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Blood volume and age: repeated measurements on normal men after 17 years.

Cited by 63 publications

References 0 publications

Plasma volume, intravascular albumin and its transcapillary escape rate in patients with extensive skin disease

Plasma volume, intravascular albumin and its transcapillary escape rate in patients with extensive skin disease

The normal ageing kidney – morphology and physiology

Short-term aerobic training and circulatory function in women: age and hormone-replacement therapy

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