Blood volume and haemodilution in extracorporeal circulation: changes during perfusion.

Hæmodilution in Clinical Extracorporeal Circulation: Some Effects of Human Serum Albumin

“…per kilogram), but found evidence of less destruction of red cells and platelets and a better microcirculation when a similar dose of low molecular weight dextran was used. Guha and Raison (1966) studied red-cell and plasma volumes during perfusion, and showed an increase in plasma volume when low molecular weight dextran (10%) was used ; they suggest that the advantage of using dextran may be that the hzmodilution is maintained over a period of time. Albumin solutions are used clinically as plasma expanders (Marshall, 1966), and would be expected to have a similar effect during perfusion.…”

“…A variety of diluent fluids is used; these include solutions of low molecular weight dextran (Mainardie et alii, 1964 ;Roe et alii, 1964)~ various dextrose and saline combinations with and without the addition of human serum albumin (Cooley et alii, 1962 ;Zuhdi et alai, 1963 ;Sessler et a&, 1965, Litvak et alii, 1965 and Ringer lactate (Neville et nlii, 1964). Guha and Raison (1966) have studied the effect of 10% low molecular weight dextran when compared with 5% dextrose or homologous blood, and suggest that the former solution reduces the-loss of fluid into the patient's circulation during cardio-pulmonary bypass. W e have compared clinical perfusions in which human serum albumin was added to dextrose saline solutions with those in which the dextrose saline solutions alone were used.…”

La función renal y su dinámica tubular en cirugía cardíaca con circulación extracorpórea y hemodilución

“…Esta anuria inicial, o bien una marcada disminución en la diuresis, ha sido confirmada por Norman 44 y Grismer 19 . En cuanto a la existencia de una tensión arterial mínima por debajo de la cual no se produce filtrado glomerular, ha sido fijada también en 65 mm Hg por Burford 4 , y en 60 mm Hg por Etheredge i+, Gadboys 17 y Moffit 38 . Sin embargo, otros autores, como Guha 20 , han obtenido diuresis por debajo de esta cifra. Senning s7 ha realizado un estudio en perros utilizando sangre completa como cebado, bien con flujo alto (95-105 ml/Kg/min) o bien con flujo bajo (35-45 ml/Kg/min), encontrando también durante perfusión un descenso significativo del GFR y del FPR con respecto al período de anestesia.…”