Blood volume and myocardial function in adrenal insufficiency

Rl, Verrier; Rovetto, MJ; Am, Lefer

doi:10.1152/ajplegacy.1969.217.6.1559

Cited by 13 publications

(3 citation statements)

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“…The possibility of a profound change in blood volume in acute adrenal insufficiency had not been examined until recently. 189 The changes in blood volume (i.e., as determined by 131J_ labeled serum albumin) observed in acutely adrenalectomized cats were not significantly different from those seen in time-matched sham-operated cats. Thus, a decrease in blood volume does not appear to be a major contributory factor in the acute circulatory collapse phenomenon.…”

Section: Cardiovascular Consequences Of Adrenocortical Insufficiencymentioning

confidence: 81%

Role of corticosteroids in the treatment of circulatory collapse states

Lefer

Verrier

1970

Clin Pharma and Therapeutics

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Corticosteroids are hormones which exert effects on virtually every organ and tissue and thereby play a key role in preserving and maintaining homeostasis. 154 In particular, corticosteroids exert prominent effects on the cardiovascular system. 65, 66 The circulatory effects of the orticosteroids have been under investigation since 1849 when Addison 2 recognized that cardiovascular collapse was a prominent feature of adrenal insufficiency. However, it has only been within the last twenty years that corticosteroids have been available in pure form, thereby permitting an investigation of their effects. The cardiovascular effects of corticosteroids are of considerable interest because hypotension is a prominent feature in adrenocortical insufficiency, and hypertension occurs in hypersecretion of adrenal corticosteroids. Furthermore, corticosteroids have been widely used in the treatment of a variety of states of circulatory shock. The particular emphasis of this review will be to discuss, in terms of recent developments in the field, the basic physiologic and pharmacologic mechanisms by means of which corticosteroids exert their cardiovascular effects in shock states. Several new findings necessitate a significant shift in our thinking about the circulatory effects of the corticosteroids.

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Section: Cardiovascular Consequences Of Adrenocortical Insufficiencymentioning

confidence: 81%

Role of corticosteroids in the treatment of circulatory collapse states

Lefer

Verrier

1970

Clin Pharma and Therapeutics

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“…Adrenalectomy is usually associated with hyponatremia and plasma volume variations (Swingle and Swingle 1967), which are influenced by the amount of NaCl in the food (Verrier et al 1969). Since vacuoles develop in areas of the centrai nervous system freely accessible not only to blood proteins but also to water and electrolytes, it is also possible that they reflect hydro-electrolytic changes within the extracellular space.…”

Section: Discussionmentioning

confidence: 99%

Transmission and scanning electron-microscopic observations on tanycytes in the mediobasal hypothalamus and the median eminence of adrenalectomized rats

Depierreux

Couck

et al. 1982

Cell Tissue Res.

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Tanycytes in the median eminence (ME) of the rat exhibit morphological features suggesting their possible participation in transport phenomena. After adrenalectomy, which modifies the hypothalamo-hypophyseal axis, they undergo morphological changes characterized by an accumulation of lipid droplets, an increased number of bleb-like protrusions at their apex, as well as an increased pinocytosis of intraventricularly injected horseradish peroxidase (HRP). In addition, after adrenalectomy an increased number of vacuoles appears at the level of the tubero-infundibular sulci. Their intracellular location in the tanycytes is demonstrated by an intraventricular injection of HRP. The significance of these vacuoles is discussed in relation to the hydroelectrolytic modifications associated with the state of adrenalectomy.

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“…KRÜS-KEMPER 1974;HERRMANN 1978;PICKARDT et al 1980), oft vom akzessorischen oder terminalen Schockgeschehen entscheidend bestimmt (SOBEL 1980 (WEISSBECKER 1965;SCRIBA u. PICKARDT 1976;FEHM et al 1980;v. WERDER U. MÜLLER 1980;SCRIBA 1982b) Erregungsrückbildungsstörungen (HARTOG U. JOPLIN 1968;VERRIER et al 1969;MAEDER et al 1974), das verminderte Ansprechen des Blutdrucks auf Angioten sin II (OGIHARA et al 1979) und die interessante Beobachtung zu beziehen, daß trotz erhöhter Reninkonzentration das Reninsubstrat auf weniger als 10% ver mindert sein kann (STOCKIGT et al 1979;MERRIAM U. BAER 1980). Nebenbei, die Differentialdiagnose der Hyponatriämie -häufig ein ominöses Zeichen -umfaßt Verdünnungshyponatriämie, diverse Natriummangelzustände einschl.…”

Section: A Endokrin-metabolische Krisen Als Schockursachenunclassified