Blood Volume in Clinical Shock.  I. Mixing Time and Disappearance Rate of T-1824 in Normal Subjects and in Patients in Shock; Determination of Plasma Volume in Man From 10-Minute Sample12

Noble, Robert P.; Gregersen, Magnus I.; Porter, Priscilla M.; Buckman, Ann

doi:10.1172/jci101695

Cited by 123 publications

(24 citation statements)

References 5 publications

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“…The plasma volume was measured with T-1824 by extrapolation of a corrected time log-concentration curve as described in the preceding report (9) ; the total blood volume was calculated from the plasma volume and the arterial hematocrit. The serum protein concentration was determined by the falling drop (10) and refractometric.…”

Section: Methodsmentioning

confidence: 99%

Blood Volume in Clinical Shock. Ii. The Extent and Cause of Blood Volume Reduction in Traumatic, Hemorrhagic, and Burn Shock12

Noble¹,

Gregersen²,

Porter³

et al. 1946

J. Clin. Invest.

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found evidence of a direct relation between the severity of shock and the extent of the reduction in blood volume. This has been clearly demonstrated in recent experimental studies on traumatic and hemorrhagic shock in dogs (4, 5) in which blood volume was determined with more dependable methods. Within the past two years, there have also been reports of similar observations on cases of shock among civilians (6, 7, 8, and others).The aim of the present investigation was: (1) to determine more precisely the relation between the loss in blood volume and the severity of shock in man, in order to provide a sound basis for estimating the amount of blood needed for replacement after various types and degrees of injury; (2) to determine the cause of blood volume reduction in traumatic shock; and, (3) to test the view, held until recently by some investigators, that hemoconcentration is a criterion of shock. MATERIAL AND METHODSThe plasma volume was measured with T-1824 by extrapolation of a corrected time log-concentration curve as described in the preceding report (9) ; the total blood volume was calculated from the plasma volume and the arterial hematocrit. The serum protein concentration was determined by the falling drop (10) and refractometric.

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Section: Methodsmentioning

confidence: 99%

Blood Volume in Clinical Shock. Ii. The Extent and Cause of Blood Volume Reduction in Traumatic, Hemorrhagic, and Burn Shock12

Noble¹,

Gregersen²,

Porter³

et al. 1946

J. Clin. Invest.

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show abstract

“…This is true not only of the radioactively tagged cell method but also of the Ashby (19) (33,34). The disappearance curve was extrapolated to the time of injection.…”

Section: Determination Of Plasma Blood and Erythrocyte Volumesmentioning

confidence: 99%

The in Vitro Preservation and Post-Transfusion Survival of Stored Blood 1

Ross

Finch²,

Peacock³

et al. 1947

J. Clin. Invest.

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“…The method has also proved reliable in the study of intravenous crystalloid (8) and colloid (9) therapy as well as in experimentally induced (10 to 12) and clinical shock (7, 12 to 14). A recent improvement in the method described by Noble (15), in which changes in dye concentration of blood samples are corrected for variations in water content as determined by serum protein measurements, should increase the applicability of the technique.…”

mentioning

confidence: 99%

Circulating Red Cell Volume Measured Simultaneously by the Radioactive Iron and Dye Methods 1

Gibson¹,

Peacock²,

Seligman³

et al. 1946

J. Clin. Invest.

132

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Blood Volume in Clinical Shock. I. Mixing Time and Disappearance Rate of T-1824 in Normal Subjects and in Patients in Shock; Determination of Plasma Volume in Man From 10-Minute Sample12

Cited by 123 publications

References 5 publications

Blood Volume in Clinical Shock. Ii. The Extent and Cause of Blood Volume Reduction in Traumatic, Hemorrhagic, and Burn Shock12

Blood Volume in Clinical Shock. Ii. The Extent and Cause of Blood Volume Reduction in Traumatic, Hemorrhagic, and Burn Shock12

The in Vitro Preservation and Post-Transfusion Survival of Stored Blood 1

Circulating Red Cell Volume Measured Simultaneously by the Radioactive Iron and Dye Methods 1

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