Blood Volume of Children With Leukemia

Linderkamp, Otwin; Lau, Bonnie; Riegel, K; Betke, Klaus

doi:10.1111/j.1651-2227.1978.tb16321.x

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…In patients with chronic kidney disease, anemia was often complicated with uid retention and overhydration, resulting in increased risk of cardiovascular morbidity and mortality and chronic kidney disease progression [25]. Expansion of plasma volume and hemodilution were important features of anemia due to hemopoietic diseases, such as leukemia [26].…”

Section: Discussionmentioning

confidence: 99%

Point-of-care ultrasound-guided conservative fluid therapy improved the outcome of critically ill patients: a before-and-after study

Zeng

Chen

et al. 2020

Preprint

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BackgroundThe danger of volume overload was not yet well understood and appreciated. Point-of-care ultrasound assessment of blood volume was not widely practiced.MethodsCritically ill patients managed with point-of-care ultrasound were compared with those managed without, in an intensive care unit (ICU) for medical and surgical cases. Distended internal jugular veins and inferior vena cava with reduced collapsibility were taken as signs of hypervolemia and negative fluid balance became a goal.ResultsCompared with critically ill patients admitted before application of point-of-care ultrasound assessment (from March, 2019 through October, 2019; 291 cases), cases admitted after (from November, 2019 through June, 2020; 285 cases) had significantly lower in-ICU mortality (34.7% vs 26.7%, p=0.038; Fisher’s exact test), together with a dramatic change from overall positive fluid balance to negative one. Multiple logistic regression showed that cumulative fluid balance during ICU stay, Acute Physiology and Chronic Health Evaluation (APACHE) II score and Sequential Organ Failure Assessment (SOFA) scores on admission were independent risk factors for in-ICU mortality (p<0.001, p<0.001 and p=0.043 respectively). After controlling for APACHE II and SOFA scores on admission, Cox hazard ratio of cases with a negative cumulative fluid balance during ICU stay was 0.683 (95% confidence interval 0.475-0.981; p=0039).ConclusionsPoint-of-care ultrasound examination of internal jugular veins and inferior vena cava directed fluid therapy to conservative strategy, and negative cumulative fluid balance during ICU stay was associated with a reduced in-ICU mortality.

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Section: Discussionmentioning

confidence: 99%

Point-of-care ultrasound-guided conservative fluid therapy improved the outcome of critically ill patients: a before-and-after study

Zeng

Chen

et al. 2020

Preprint

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The splenomegaly of myeloproliferative disorders: Effects on blood volume and red blood count

Zhang

Lewis

1989

European J of Haematology

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By means of a scintigraphic method for estimation of spleen size, the relationship was studied between spleen size and anaemia, total blood volume and red cell volume in patients with myeloproliferative disorders. There was significant correlation between spleen size and Hb, RBC and PCV in myelofibrosis. The size of the enlarged spleen did not, however, correlate with the degree of anaemia in the leukaemias. There was positive correlation between spleen size and red cell volume in these conditions. It was not possible to evaluate the severity of polycythaemia from spleen size and the degree of enlargement of the spleen does not appear to be a reliable parameter for staging and deciding on treatment in patients with PPP.

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Point-of-Care Ultrasound-Guided Conservative Fluid Therapy Improved the Outcome of Critically Ill Patients: A Before-and-After Study

He¹,

Zeng²,

Chen³

et al. 2021

Preprint

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ObjectivesTo study the impact of fluid balance on the outcome of critically ill patients.MethodsCritically ill patients managed with point-of-care ultrasound were compared with those managed without. Distended internal jugular veins and inferior vena cava with reduced collapsibility were taken as signs of hypervolemia.ResultsCompared with critically ill patients admitted before application of point-of-care ultrasound assessment (from March, 2019 through October, 2019; 291 cases), cases admitted after (from November, 2019 through June, 2020; 285 cases) had significantly lower in-ICU mortality (34.7% vs 26.7%, p=0.038; Fisher’s exact test), together with a dramatic change from overall positive fluid balance to negative one (for cumulative fluid balance during ICU stay, 2820±1381ml vs -10±39ml; p=0.001). Multiple logistic regression showed that cumulative fluid balance during ICU stay, Acute Physiology and Chronic Health Evaluation (APACHE) II score and Sequential Organ Failure Assessment (SOFA) score on admission were independent risk factors for in-ICU mortality (p<0.001, p<0.001 and p=0.043 respectively). After controlling for disease severity, Cox hazard ratio of cases with a negative cumulative fluid balance during ICU stay was 0.683 (95% confidence interval 0.475-0.981; p=0039).ConclusionsNegative cumulative fluid balance during ICU stay was associated with a reduced in-ICU mortality.

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Blood Volume of Children With Leukemia

Cited by 3 publications

References 14 publications

Point-of-care ultrasound-guided conservative fluid therapy improved the outcome of critically ill patients: a before-and-after study

Point-of-care ultrasound-guided conservative fluid therapy improved the outcome of critically ill patients: a before-and-after study

The splenomegaly of myeloproliferative disorders: Effects on blood volume and red blood count

Point-of-Care Ultrasound-Guided Conservative Fluid Therapy Improved the Outcome of Critically Ill Patients: A Before-and-After Study

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