Blood Volume Studies in Patients with Splenomegaly

Bowdler, A. J.

doi:10.1111/j.1537-2995.1970.tb00727.x

Cited by 37 publications

(15 citation statements)

References 25 publications

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“…The present data indicate that the extramedullary tissue in the liver is also relatively rich in erythroid cells. It is known that haemodilution and sequestration of red cells in the enlarged spleen contribute to the development of anaemia in CML [2,3,9]. The low mitotic activity of the spleen and liver erythroblasts may help to explain why the large amount of extramedullary erythropoietic tissue in advanced CML obviously fails to compensate factors that promote the development of anaemia.…”

Section: Discussionmentioning

confidence: 99%

Different Composition and Mitotic Activity of the Haemopoietic Tissue in Bone Marrow, Spleen and Liver in Chronic Myeloid Leukaemia

Sjögren¹,

Brandt²

1976

Acta Haematol

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Aspirates from bone marrow, spleen and liver were analyzed in 15 untreated patients with chronic myeloid leukaemia (CML). The proportion of erythroblasts was higher in the spleen and liver than in the bone marrow. An increased frequency of basophilic leucocytes was recorded in the extramedullary sites compared to the bone marrow. In the liver aspirates a considerable admixture of lymphocytes was found. The mitotic indices of the granulopoietic and erythropoietic precursor cells were lower in the spleen and liver than in the bone marrow. The results indicate that the composition and proliferative activity of the haemopoietic tissue differ in bone marrow and extramedullary sites in CML. The discrepancies may be due to differences in the microenvironment for the haemopoietic cells or to a selective accumulation of cells with a low mitotic activity in extramedullary sites. Since the final blastic transformation of CML may originate outside the bone marrow, further studies of the extramedullary haemopoietic tissue may be worthwhile.

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Section: Discussionmentioning

confidence: 99%

Different Composition and Mitotic Activity of the Haemopoietic Tissue in Bone Marrow, Spleen and Liver in Chronic Myeloid Leukaemia

Sjögren¹,

Brandt²

1976

Acta Haematol

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“…It has pre viously been demonstrated that haemolysis [2], haemodilution and spleen sequestration of erythrocytes [3][4][5] may contribute to the anaemia. A re duced differentiation of basophilic erythroblasts towards more mature cells has also been proposed [9,11].…”

mentioning

confidence: 99%

Erythroblastic Islands and Extra-Medullary Erythropoiesis in Chronic Myeloid Leukaemia

Sjögren¹

1976

Acta Haematol

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Aspirates from bone marrow, spleen and liver were morphologically analysed in 15 untreated patients with chronic myeloid leukaemia. Megaloblastic changes of the erythroblasts were found to be more common in the spleen and liver than in the bone marrow. A significant increase of ‘erythroblastic islands’, i.e. erythroblasts in contact with reticulum cells, were recorded in the leukaemia patients compared to 15 healthy controls. It is suggested that the presence of such formations may indicate an increased death rate of defective erythroblasts followed by phagocytosis into reticuloendothelial cells.

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“…The only common factor in this wide spectrum of diseases is the gross splenomegaly, and it is now clear that the degree of expansion of the plasma volume is directly proportional to spleen size (Pryor, 1967b;Blendis, Toghill, and Williams, 1969). Increases of 1-5 to 2-5% in the total blood volume and plasma volume have been predicted for each centimetre increase in the distance of the spleen tip from the costal margin (Bowdler, 1970).…”

Section: Discussionmentioning

confidence: 87%

“…Bowdler (1970) has pointed out that enlargement of such a vascular organ as the spleen requires an expansion of the blood volume to fill the additional intravascular space. In conditions where the erythropoietic activity of the marrow might be inadequate to maintain the normal red cell/plasma ratio, the additional volume could be provided by plasma expansion.…”

Section: Discussionmentioning

confidence: 99%

The influence of spleen size on the distribution of red cells and plasma

Toghill

Green

1972

J Clin Pathol

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The red cell mass, splenic red cell pool, and plasma volume have been measured in a series of 64 patients with splenomegaly due to haematological disorders. In 45 patients the total blood volume was increased, this being due to expansion of the plasma volume which was closely correlated with spleen size. There was no significant relationship between the red cell mass and spleen size but the splenic red cell pool increased with increasing spleen size. In 12 patients serial estimations were made whilst changes in spleen size occurred as a result of therapy or progression of the disease. The red cell mass did not alter but the splenic red cell pool showed a significant change from 8·9 ± 6·1% of the red cell mass at minimum spleen size to 17·5 ± 10·5% at maximum spleen size. There was progressive expansion of the plasma volume from 42·9 ± 5·0 ml/kg at minimum spleen size to 57·4 ± 15·3 ml/kg at maximum spleen size.

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Blood Volume Studies in Patients with Splenomegaly

Cited by 37 publications

References 25 publications

Different Composition and Mitotic Activity of the Haemopoietic Tissue in Bone Marrow, Spleen and Liver in Chronic Myeloid Leukaemia

Different Composition and Mitotic Activity of the Haemopoietic Tissue in Bone Marrow, Spleen and Liver in Chronic Myeloid Leukaemia

Erythroblastic Islands and Extra-Medullary Erythropoiesis in Chronic Myeloid Leukaemia

The influence of spleen size on the distribution of red cells and plasma

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