The aim of this study was to compare the Cavitron ultrasonic surgical aspirator (CUSA) with bipolar cautery (BP) to CUSA with a radiofrequency coagulator [TissueLink (TL)] in terms of efficacy and safety for hepatic transection in living donor liver transplantation. Twenty-four living liver donors (n ϭ 12 for each group) were randomized to undergo hepatic transection using CUSA with BP or CUSA with TL. Blood loss during parenchymal transection and speed of transection were the primary endpoints, whereas the degree of postoperative liver injury and morbidity were secondary endpoints. Median blood loss during liver transection was significantly lower in the TL group than in the BP group (195.2 Ϯ 84.5 versus 343.3 Ϯ 198.4 mL; P ϭ 0.023), and liver transection was significantly faster in the TL group than in the BP group (0.7 Ϯ 0.2 versus 0.5 Ϯ 0.2 cm 2 /minute; P ϭ 0.048). Significantly fewer ties were required during liver transection in the TL group than in the BP group (15.8 Ϯ 4.8 versus 22.8 Ϯ 7.9 ties; P ϭ 0.023). The morbidity rates were similar for the 2 groups. In conclusion, CUSA with TL is superior to CUSA with BP for donor hepatectomy in terms of blood loss and speed of transection with no increase in morbidity. Intraoperative blood loss remains a major concern for hepatic surgeons 1,2 as it is associated with an increased rate of postoperative morbidity and mortality as well as reduced long-term survival. 3,4 Most blood loss occurs during parenchymal transection. 5 However, advances in surgical technique, low central venous pressure anesthesia, and tissue sealants have reduced this risk. 6 Several techniques have been developed for safe and careful parenchymal dissection. The most popular devices facilitating bloodless transection include standard bipolar cautery (BP), the Cavitron ultrasonic surgical aspirator (CUSA; Tyco Healthcare, Mansfield, MA) using ultrasonic energy, the Hydro-Jet (Erbe, Tubingen, Germany) using a pressurized jet of water, and the radiofrequency (RF) coagulator [TissueLink (TL); TissueLink Medical, Inc., Dover, NH] using RF energy. 5,7 In living donor liver transplantation (LDLT), donor safety is absolutely of the utmost importance. 8 Therefore, we usually perform donor hepatectomy using