Blue cotton, Blue Rayon and Blue Chitin in the analysis of heterocyclic aromatic amines—a review

Skog, Kerstin

doi:10.1016/j.jchromb.2003.11.016

Cited by 39 publications

(38 citation statements)

References 47 publications

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“…SPE sorbents, such as Blue Rayon, 33,34 Blue Cotton, 25,35,36 and Blue Chitin 17,37 offer high selectivity for polycyclic aromatic compounds [38][39][40] and selectively isolate target HCAs from urine. However, the major obstacle in the processes of adsorption and desorption using SPE is the extraction efficiency.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Heterocyclic Amines in Human Urine Using Multiple Solid-Phase Extraction by Liquid Chromatography/Mass Spectrometry

Cha

Kim²,

Jeong³

et al. 2010

Bulletin of the Korean Chemical Society

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A multiple solid-phase extraction (SPE) method was used with liquid chromatography, coupled with mass spectrometry (LC/MS), for the analysis of heterocyclic amines (HCAs) in human urine. Separation efficiencies based on the pH of the mobile phase and the types of columns were compared. An amide column showed better baseline separation and narrower HCA peak widths at pH 5.0 for the mobile phase than a C8 column. Each SPE step, HLB, MCX, and HybridSPE, was optimized by controlling the pH conditions. The combined method with the three SPEs effectively removed interfering species that cause ion-suppression during HCA detection. Validation of the method, performed with SIM and SRM detection, showed correlation coefficients above 0.991 in the range 0.3 -16.7 ng/mL. Recovery rates were 45.4 -97.3% on the C8 column and 71.8 -101.4% on the amide column, and method detection limits were 0.11 -0.65 ng/mL on the C8 column and 0.12 -0.48 ng/mL on the amide column. This method using multiple SPEs offers significant benefits for high-throughput determination of HCAs in urine.

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Section: Introductionmentioning

confidence: 99%

Analysis of Heterocyclic Amines in Human Urine Using Multiple Solid-Phase Extraction by Liquid Chromatography/Mass Spectrometry

Cha

Kim²,

Jeong³

et al. 2010

Bulletin of the Korean Chemical Society

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“…O Blue rayon, similarmente ao Blue cotton, é um conjunto de fibras inertes de rayon ligadas covalentemente ao mesmo pigmento, ftalocianina de cobre tiossulfato, contendo 2-3 vezes mais ligantes (aproximadamente 30 µmol/g peso seco) que o Blue cotton (10 µmol/g peso seco). A estrutura do Blue rayon não foi encontrada na literatura pesquisada [12][13][14] . O Blue rayon tem sido mais utilizado que o Blue cotton como adsorvente de substâncias com estrutura molecular planar e policíclica presentes em amostras de alimentos, águas e materiais biológicos 11,15,16 .…”

Section: Introductionunclassified

“…O mecanismo pelo qual o Blue cotton, Blue rayon e a Blue chitin adsorvem os compostos policíclicos está diretamente relacionado com a característica planar deste tipo de molécula 16 . Uma ligação hidrofóbica 1:1 é formada com o pigmento ftalocianina de cobre tiossulfato, que tem uma grande estrutura molecular planar 14 . Preferencialmente são adsorvidos pelo Blue rayon os compostos com três ou mais anéis fundidos em sua molécula.…”

Section: Introductionunclassified

Uso do Blue Rayon para extração/concentração de compostos policíclicos em amostras ambientais

Kummrow

Umbuzeiro

2006

Quím. Nova

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“…1) are mutagenic factors that are predominantly ingested as pyrolysis products of meats and fishes.1) To adsorb the HCAs on ligands, a cellulose coupled with a Cu-phthalocyanine derivative (Cu-PC, a related compound metal-porphyrin), so-called "blue cotton," was developed, 2,3) which was reported to be beneficial for callbacks and determinations of HCAs in environmental waters 2) and air-born particules.4) The adsorption of HCAs on the blue cotton is caused by hydrophobic p-p interaction between HCAs and Cu-PC coupled with cotton fiber. Peroxidase (POD), of which active cite is Fe-protoporphyrin, was reported to catalyze oxidative reactions of a wide range of mutagens and carcinogens including HCAs, thereby decreasing the mutagenicity and carcinogenicity.…”

mentioning

confidence: 99%

“…1) To adsorb the HCAs on ligands, a cellulose coupled with a Cu-phthalocyanine derivative (Cu-PC, a related compound metal-porphyrin), so-called "blue cotton," was developed, 2,3) which was reported to be beneficial for callbacks and determinations of HCAs in environmental waters 2) and air-born particules.…”

mentioning

confidence: 99%

Peroxidase-Like Catalytic Activity of Anion-Exchange Resins Modified with Metal-Porphyrins in Oxidative Reaction of Hetrocyclic Amines with Hydrogen Peroxide

Mifune

Hino

Sugita

et al. 2005

CHEMICAL & PHARMACEUTICAL BULLETIN

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Heterocyclic amines (HCAs, Fig. 1) are mutagenic factors that are predominantly ingested as pyrolysis products of meats and fishes.1) To adsorb the HCAs on ligands, a cellulose coupled with a Cu-phthalocyanine derivative (Cu-PC, a related compound metal-porphyrin), so-called "blue cotton," was developed, 2,3) which was reported to be beneficial for callbacks and determinations of HCAs in environmental waters 2) and air-born particules.4) The adsorption of HCAs on the blue cotton is caused by hydrophobic p-p interaction between HCAs and Cu-PC coupled with cotton fiber. Peroxidase (POD), of which active cite is Fe-protoporphyrin, was reported to catalyze oxidative reactions of a wide range of mutagens and carcinogens including HCAs, thereby decreasing the mutagenicity and carcinogenicity. 5,6) In the above cases, metal-porphyrin derivatives serve as an adsorbent of HCAs or a catalysis of oxidative reaction of mutagens.On the other hand, we previously reported that some anion-exchangers modified with metal-tetrakis(sulfophenyl)-porphines (M-TSPP r ) exhibited a peroxidase (POD)-like activity and was applicable to the determination of hydrogen peroxide as a solid-mimesis of horse radish POD. 7,8) In the present paper, we investigated the POD-like activity of M-TSPP r s in the oxidation of HCAs to elucidate the usefulness of M-TSPP r s as a POD-like catalyst in the oxidation of HCAs. We revealed that some M-TSPP r s exhibit a similar POD-like activity for HCAs to horse radish POD. In particular, Fe-and Mn-TSPP r s catalyze the oxidation of 2-amino-3-methyl-imidazo[4,5-f ]quinoline (IQ) with hydrogen peroxide. The resulting IQ-dimmer has no mutagenicity in umutest. We elucidated that M-TSPP r can decrease mutagenicity of HCAs in vitro through its POD-like catalytic activity. ExperimentalMaterials Tetrakis(sulfophenyl)porphine (H 2 -TSPP) was purchased from Wako Junyaku Co. Ltd. (Osaka, Japan). Mutagenic HCAs (see Fig. 1), IQ, MeIQ, MeIQx, TrpP-1 and TrpP-2, were purchased from Wako Junyaku Co. Ltd. GluP-1 and GluP-2 (Chemsyn Science Laboratories, Lenaxa, Kansas, U.S.A.) were kindly donated from Prof. Hikoya Hayatsu (Shujitsu University). They were used without further purification. An anion-exchange resin, Amberlite IRA 900 (24-42 mesh) in nitrate form, was a manufacture of Organo Chemical Co. Ltd. (Tokyo, Japan). Other reagents were of analytical or reagent grade. umu-Test kit was purchased from Japan Immunoresearch Laboratories Co. Ltd. (Takasaki, Japan).Apparatus Absorption (UV/V) spectra and absorbances (abbr. "A") were measured on a Shimadzu UV-180 or a JASCO V-570 spectrophotometer with 10 mm quartz cells. HPLC system was constructed with a Shimadzu pump (LC-6A), a Shimadzu photodiode array detector (SPD-M6A) and a To elucidate the peroxidase (POD)-like catalytic activity of anion-exchange resins modified with metaltetrakis(sulfophenyl)porphine (M-TSPP r s), an oxidative reaction of seven mutagenic heterocyclic amines (HCAs) with hydrogen peroxide, which reaction is catalyzed by horse radish POD, was investigate...

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Blue cotton, Blue Rayon and Blue Chitin in the analysis of heterocyclic aromatic amines—a review

Cited by 39 publications

References 47 publications

Analysis of Heterocyclic Amines in Human Urine Using Multiple Solid-Phase Extraction by Liquid Chromatography/Mass Spectrometry

Analysis of Heterocyclic Amines in Human Urine Using Multiple Solid-Phase Extraction by Liquid Chromatography/Mass Spectrometry

Uso do Blue Rayon para extração/concentração de compostos policíclicos em amostras ambientais

Peroxidase-Like Catalytic Activity of Anion-Exchange Resins Modified with Metal-Porphyrins in Oxidative Reaction of Hetrocyclic Amines with Hydrogen Peroxide

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