Blue dyes, blue people: the systemic effects of blue dyes when administered via different routes

Yusim, Yakov; Livingstone, David J.; Sidi, Avner

doi:10.1016/j.jclinane.2007.01.006

Cited by 42 publications

(25 citation statements)

References 38 publications

(45 reference statements)

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“…Although there are cases of dermatological symptoms due to blue dyes, this is the first case report of AGEP due to blue dyes [9-11]. Our AGEP diagnosis, which was aided by a skin biopsy and clinical findings, was confirmed.…”

Section: Discussionsupporting

confidence: 55%

Acute Generalized Exanthematous Pustulosis Due to Oral Use of Blue Dyes

Şener

Köse

Özgür

et al. 2011

Korean J Intern Med

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Acute generalized exanthematous pustulosis is a rare severe pustular cutaneous adverse reaction characterized by a rapid clinical course with typical histological findings. It is accompanied by fever and acute eruption of non-follicular pustules overlying erythrodermic skin. The causative agents are most frequently antibacterial drugs. We present a patient with acute generalized exanthematous pustulosis caused by methylene blue and indigotin dyes.

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Section: Discussionsupporting

confidence: 55%

Acute Generalized Exanthematous Pustulosis Due to Oral Use of Blue Dyes

Şener

Köse

Özgür

et al. 2011

Korean J Intern Med

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“…MB accelerates the normally slow NADP (nicotinamide adenine dinucleotide phosphate) methemoglobin reductase pathway [24], the mechanism by which physiologically produced methemoglobin is reduced. However, MB can also cause methemoglobinemia when administered at a higher dose [25], due to its strong oxidizing capacity [26] which produces equilibrium between hemoglobin and methemoglobin.…”

Section: Mb's Hormetic Dose-response Effects On Various Physiologicalmentioning

confidence: 99%

Behavioral, Physiological and Biochemical Hormetic Responses to the Autoxidizable Dye Methylene Blue

Bruchey¹,

González-Lima²

2008

American J. of Pharmacology and Toxicology

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The goals of this review were to identify methylene blue (MB) as a compound that follows hormetic behavior for a wide range of effects and to address the question of what is unique about MB that could account for its wide applicability and hormetic behavior as a drug. The MB hormetic doseresponse relationship is exemplified by an increase in various behavioral, physiological and biochemical responses with increasing dose, followed by a decrease in the same responses with an even higher dose, until the responses are equal to control responses. With MB doses increasing beyond the hormetic zone, the responses decrease even further, until they are below the control responses. At doses spanning its hormetic zone, MB can increase select responses until they are 130-160% of control. For example, low doses of MB produce maximum behavioral and biochemical responses with averages of approximately 140% of control. As MB dose is raised outside the hormetic zone the response decreases below the control response, as exemplified by MB's ability to increase cytochrome oxidase activity at intermediate doses, while decreasing cytochrome oxidase activity at higher doses. It is proposed that MB's autoxidizable chemical property may be responsible for its unique biological action as both a metabolic energy enhancer and antioxidant that is frequently characterized by hormetic dose-response relationships.

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“…Dyes that absorb light at similar wavelengths, such as methylene blue, isosulfan blue and indigo carmine, can falsely decrease pulse oximeter readings [1,2]. The measurement of cerebral regional tissue oxyhaemoglobin saturations may also be susceptible to dye-induced artefact as they are based on light absorption at similar wavelengths [3].…”

Section: Introductionmentioning

confidence: 99%

The effects of Patent Blue dye on peripheral and cerebral oxyhaemoglobin saturations

et al. 2014

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SummaryWe measured the effect of Patent Blue dye on oxyhaemoglobin saturations after injection into breast tissue: 40 women had anaesthesia for breast surgery maintained with sevoflurane or propofol (20 randomly allocated to each). Saturations were recorded with a digital pulse oximeter, in arterial blood samples and with a cerebral tissue oximeter before dye injection and 10, 20, 30, 40, 50, 60, 75, 90, 105 and 120 min afterwards. Patent Blue did not decrease arterial blood oxyhaemoglobin saturation, but it did reduce mean (SD) digital and cerebral oxyhaemoglobin saturations by 1.1 (1.1) % and 6.8 (7.0) %, p < 0.0001 for both. The falsely reduced oximeter readings persisted for at least 2 h. The mean (SD) intra-operative digital pulse oxyhaemoglobin readings were lower with sevoflurane than propofol, 97.8 (1.2) % and 98.8 (1.0) %, respectively, p < 0

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Blue dyes, blue people: the systemic effects of blue dyes when administered via different routes

Cited by 42 publications

References 38 publications

Acute Generalized Exanthematous Pustulosis Due to Oral Use of Blue Dyes

Acute Generalized Exanthematous Pustulosis Due to Oral Use of Blue Dyes

Behavioral, Physiological and Biochemical Hormetic Responses to the Autoxidizable Dye Methylene Blue

The effects of Patent Blue dye on peripheral and cerebral oxyhaemoglobin saturations

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