Blue light: Friend or foe ?

Bonnans, M.; Fouque, Linda; Pelletier, Michele; Chabert, R.; Pinacolo, Sandrine; Restellini, Laura; Cucumel, K.

doi:10.1016/j.jphotobiol.2020.112026

Cited by 22 publications

(21 citation statements)

References 36 publications

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“…As for the risks, the increasing number of in vitro studies using 2D human cell cultures that purport to show DNA damage, photodamage of fibrillin, elastin, collagen, induction of apoptosis as a result of altering activity of a varieties of proteins, including MMPs, and so forth has raised concerns [79,[102][103][104][105].…”

Section: Discussionmentioning

confidence: 99%

“…rather than as intact and multicellular 3D skin tissues. Thus, much caution is needed when reviewing data purporting to link blue light irradiation effects on photodamage of DNA, fibrillin, elastin, collagen, induction of apoptosis, alterations in proteins, including MMPs, and so forth in human skin cells [79]. While in vitro cell culture data may identify fundamental mechanisms of light interaction with cutaneous cells [8,[80][81][82] and clearly are attractive for researchers eager to avoid the complexity of running clinical studies on living human subjects, there is growing concern in biomedicine as to whether cell culture models can ever accurately reflect multilayered processes in real living humans [83].…”

Section: Controversies Between In Vivo and In Vitro Studiesmentioning

confidence: 99%

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Highlighting nuances of blue light phototherapy: Mechanisms and safety considerations

Uzunbajakava

Tobin

Botchkareva

et al. 2022

Journal of Biophotonics

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The efficacy of blue light therapy in dermatology relies on numerous clinical studies. The safety remains a topic of controversy, where potentially deleterious effects were derived from in vitro rather than in vivo experiments. The objectives of this work were (1) to highlight the nuances behind “colors” of blue light, light propagation in tissue and the plurality of modes of action; and (2) to rigorously analyze studies on humans reporting both clinical and histological data from skin biopsies with focus on DNA damage, proliferation, apoptosis, oxidative stress, impact on collagen, elastin, immune cells, and pigmentation. We conclude that blue light therapy is safe for human skin. It induces intriguing skin pigmentation, in part mediated by photoreceptor Opsin‐3, which might have a photoprotective effect against ultraviolet irradiation. Future research needs to unravel photochemical reactions and the most effective and safe parameters of blue light in dermatology.

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Section: Discussionmentioning

confidence: 99%

Section: Controversies Between In Vivo and In Vitro Studiesmentioning

confidence: 99%

Highlighting nuances of blue light phototherapy: Mechanisms and safety considerations

Uzunbajakava

Tobin

Botchkareva

et al. 2022

Journal of Biophotonics

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“…Blue light therapy (BLT) has been extensively applied for managing cutaneous diseases and for accelerating skin injury repair. 12 Researchers have found that the application of BLT to the skin has bactericidal, 13 anti-contamination, 14 and antiinflammatory 15 effects. Consequently, antimicrobial BLT (aBLT) has shown an extensive variety of anti-bacterial effects against gram-positive and gram-negative bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…16,17 The preliminary favorable results of BLT applications have directed researchers toward the expansion of phototherapy as well as PBM therapy in wound healing. 12 Several recent review articles have stated the importance of using blue light to accelerate wound healing. 10,18,19 The effects of BLT on skin wound healing have received much notice during the previous two decades.…”

Section: Introductionmentioning

confidence: 99%

Impact of Blue Light Therapy on Wound Healing in Preclinical and Clinical Subjects: A Systematic Review

Bayat

Albright²,

Hamblin

et al. 2022

J Lasers Med Sci

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Introduction: While a wound caused by a minor cutaneous incision routinely heals in a short time, wounds from major surgical operations might need numerous days to heal and may leave an obvious cicatrix. The use of blue light therapy (BLT) to destroy infectious microorganisms and disrupt biofilm formation could be an efficient method for healing ulcers. This systematic review focused on the effects of BLT in different preclinical in vivo studies and clinical models of skin wound healing. Furthermore, this study attempted to determine what main light parameters should be tested in preclinical and clinical studies. Methods: The online databases PubMed.gov, Google Scholar, Scopus, Web of Science, and Cochrane were searched using the keywords "blue light" and "wound healing" according to PRISMA guidelines. No publication time limit was enforced. Results: A total of 858 articles were identified, and 17 articles in three distinct categories were included for review. They comprised two articles on humans, fourteen articles on healthy animals, and one article on diabetic animals. Conclusion: Some studies have shown that the application of BLT on preclinical and clinical models of wound healing in vivo is able to significantly accelerate the healing process. Few studies, however, have explored the bactericidal effect of BLT on skin injury repair in burn patients. Further preclinical investigations designed to provide a better understanding of the bactericidal effect of BLT using standardized protocols, different BLT wavelengths, and different stages of the wound healing process of infected wounds and ulcers in healthy and diabetic animals should be carried out before clinical trials can be considered. BLT could eventually be a good option for treating infected chronic wounds, including those in diabetic patients.

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“…Acquired genetic mutations are often a result of carcinogen exposure. One of the best-known human carcinogens is ultraviolet B (UVB) light (Bonnans, 2020). UVB can directly induce cyclobutene pyrimidine dimers (CPDs) and pyrimidine-pyrimidone (6 − 4) photoproducts (6 − 4 PPs) at dipyrimidine sites.…”

Section: Introductionmentioning

confidence: 99%

HotSPOT: a computational tool to design targeted sequencing panels to assess early photocarcinogenesis

Grant

Rosario

Patentreger

et al. 2022

Preprint

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Mutations found in skin are acquired in specific patterns, clustering around mutation-prone genomic locations. The most mutation-prone genomic areas, mutation hotspots, first induce the growth of small cell clones in healthy skin. Mutations accumulate over time, and driver mutation clones may give rise to skin cancer. Early mutation accumulation is a crucial first step in photocarcinogenesis. Therefore, a sufficient understanding of the process may help predict disease onset and identify avenues for skin cancer prevention. Early epidermal mutation profiles are typically established using high depth targeted next-generation sequencing. However, there is currently a lack of tools for designing custom panels to capture mutation-enriched genomic regions efficiently. To address this issue, we created a computational algorithm that implements a pseudo-exhaustive approach to identify the best targeted genomic areas. We benchmarked the current algorithm in three independent mutation datasets of human epidermal samples. Compared to the sequencing panel designs originally used in these publications, the mutation capture efficacy (# of mutations/base pairs sequenced) of our designed panel improved 9.6 to 12.1-fold. Our web application hotSPOT provides a publicly available resource for researchers to design custom panels, enabling efficient detection of somatic mutations in clinically normal tissues and other similar targeted sequencing studies.

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Blue light: Friend or foe ?

Cited by 22 publications

References 36 publications

Highlighting nuances of blue light phototherapy: Mechanisms and safety considerations

Highlighting nuances of blue light phototherapy: Mechanisms and safety considerations

Impact of Blue Light Therapy on Wound Healing in Preclinical and Clinical Subjects: A Systematic Review

HotSPOT: a computational tool to design targeted sequencing panels to assess early photocarcinogenesis

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